Immunogenicity 9370

summary
Sample ID
4007
Response
Negative
Tumor Type
Colon cancer
Gene Symbol
GRK6
Transcript ID
NM_002082
HLA INFO
DQA*01:02 / DQB*06:02
TCR INFO

No TCR info found!

T cell Tumor cell { DQA*01:02 DQB*06:02
sequence
Full length protein sequence (589 aa)
MELEN
1
IVANT
6
VLLKA
11
REGGG
16
GNRKG
21
KSKKW
26
RQMLQ
31
FPHIS
36
QCEEL
41
RLSLE
46
RDYHS
51
LCERQ
56
PIGRL
61
LFREF
66
CATRP
71
ELSRC
76
VAFLD
81
GVAEY
86
EVTPD
91
DKRKA
96
CGRQL
101
TQNFL
106
SHTGP
111
DLIPE
116
VPRQL
121
VTNCT
126
QRLEQ
131
GPCKD
136
LFQEL
141
TRLTH
146
EYLSV
151
APFAD
156
YLDSI
161
YFNRF
166
LQWKW
171
LERQP
176
VTKNT
181
FRQYR
186
VLGKG
191
GFGEV
196
CACQV
201
RATGK
206
MYACK
211
KLEKK
216
RIKKR
221
KGEAM
226
ALNEK
231
QILEK
236
VNSRF
241
VVSLA
246
YAYET
251
KDALC
256
LVLTL
261
MNGGD
266
LKFHI
271
YHMGQ
276
AGFPE
281
ARAVF
286
YAAEI
291
CCGLE
296
DLHRE
301
RIVYR
306
DLKPE
311
NILLD
316
DHGHI
321
RISDL
326
GLAVH
331
VPEGQ
336
TIKGR
341
VGTVG
346
YMAPE
351
VVKNE
356
RYTFS
361
PDWWA
366
LGCLL
371
YEMIA
376
GQSPF
381
QQRKK
386
KIKRE
391
EVERL
396
VKEVP
401
EEYSE
406
RFSPQ
411
ARSLC
416
SQLLC
421
KDPAE
426
RLGCR
431
GGSAR
436
EVKEH
441
PLFKK
446
LNFKR
451
LGAGM
456
LEPPF
461
KPDPQ
466
AIYCK
471
DVLDI
476
EQFST
481
VKGVE
486
LEPTD
491
QDFYQ
496
KFATG
501
SVPIP
506
WQNEM
511
VETEC
516
FQELN
521
VFGLD
526
GSVPP
531
DLDWK
536
GQPPA
541
PPKKG
546
LLQRL
551
FSRQR
556
IAVET
561
AATAR
566
KSSPP
571
ASSPQ
576
PEAPT
581
SSWR
586
Mutation Information
DNA mutation:
None
Peptide Range:
434 ~ 458
Mut AA position:
446 (13 in Wild Type peptide)
Alignment
Wild Type:
"CRGGSAREVKEHPLFKKLNFKRLGA
||||||||||||.||||||||||||
Mutant:
CRGGSAREVKEHRLFKKLNFKRLGA"
reference

Science, 2015

Immunogenicity of somatic mutations in human gastrointestinal cancers

Gene Name (from Reference) GRK6

clinic trial
Checkpoint Blockade

None

ACT

None

Vaccination

None

Curative Effect

None

experiment
minimal_peptide

None

Antigen Type

TMG RNA

T-cell Source

TILs

APC Type

autologous DCs

Assay

IFNg ELISPOT assay