Immunogenicity 9946

summary
Sample ID
3812
Response
Negative
Tumor Type
Bile duct cancer
Gene Symbol
TNRC18P2
Transcript ID
ENST00000399537
HLA INFO
DQA*01:03 / DQB*02:02
TCR INFO

No TCR info found!

T cell Tumor cell { DQA*01:03 DQB*02:02
sequence
Full length protein sequence (2968 aa)
MDGRD
1
FGPQR
6
SVHGP
11
PPPLL
16
SGLAM
21
DSHRV
26
GAATA
31
GRLPA
36
SGLPG
41
PLPPG
46
KYMAG
51
LNLHP
56
HPGEA
61
FLGSF
66
VASGM
71
GPSAS
76
SHGSP
81
VPLPS
86
DLSFR
91
SPTPS
96
NLPMV
101
QLWAA
106
HAHEG
111
FSHLP
116
SGLYP
121
SYLHL
126
NHLEP
131
PSSGS
136
PLLSQ
141
LGQPS
146
IFDTQ
151
KGQGP
156
GGDGF
161
YLPTA
166
GAPGS
171
LHSHA
176
PSART
181
PGGGH
186
SSGAP
191
AKGSS
196
SRDGP
201
AKERA
206
GRGGE
211
PPPLF
216
GKKDP
221
RARGE
226
EASGP
231
RGVVD
236
LTQEA
241
RAEGR
246
QDRGP
251
PRLAE
256
RLSPF
261
LAESK
266
TKNAA
271
LQPSV
276
LTMCN
281
GGAGD
286
VGLPA
291
LVAEA
296
GRGGA
301
KEAAR
306
QDEGA
311
RLLRR
316
TETLL
321
PGPRP
326
CPSPL
331
PPPPA
336
PPKGP
341
PAPPA
346
ATPAG
351
VYTVF
356
REQGR
361
EHRVV
366
APTFV
371
PSVEA
376
FDERP
381
GPIQI
386
ASQAR
391
DARAR
396
EREAG
401
RPGVL
406
QAPPG
411
SPRPL
416
DRPEG
421
LREKN
426
SVIRS
431
LKRPP
436
PADAP
441
TVRAT
446
RASPD
451
PRAYV
456
PAKEL
461
LKPEA
466
DPRPC
471
ERAPR
476
GPAGP
481
AAQQA
486
AKLFG
491
LEPGR
496
PPPTG
501
PEHKW
506
KPFEL
511
GNFAA
516
TQMAV
521
LAAQH
526
HHSRA
531
EEEAA
536
VVAAS
541
SSKKA
546
YLDPG
551
AVLPR
556
SAATC
561
GRPVA
566
DMHSA
571
AHGSG
576
EASAM
581
QSLIK
586
YSGSF
591
ARDAV
596
AVRPG
601
GCGKK
606
SPFGG
611
LGTMK
616
PEPAP
621
TSAGA
626
SRAQA
631
RLPHS
636
GGPAA
641
GGGRQ
646
LKRDP
651
ERPES
656
AKAFG
661
REGSG
666
AQGEA
671
EVRHP
676
PVGIA
681
VAVAR
686
QKDSG
691
GSGRL
696
GPGLV
701
DQERS
706
LSLSN
711
VKGHG
716
RADED
721
CVDDR
726
ARHRE
731
ERLLG
736
ARLDR
741
DQEKL
746
LRESK
751
ELADL
756
ARLHP
761
TSCAP
766
NGLNP
771
NLMVT
776
GGPAL
781
AGSGR
786
WSADP
791
AAHLA
796
THPWL
801
PRSGN
806
ASMWL
811
AGHPY
816
GLGPP
821
SLHQG
826
MAPAF
831
PPGLG
836
GSLPS
841
AYQFV
846
RDPQS
851
GQLVV
856
IPSDH
861
LPHFA
866
ELMER
871
ATVPP
876
LWPAL
881
YPPGR
886
SPLHH
891
AQQLQ
896
LFSQQ
901
HFLRQ
906
QEFLY
911
LQQQA
916
AQALE
921
LQRSA
926
QLVQE
931
RLKAQ
936
EHRAE
941
MEEKG
946
SKRGL
951
EAAGK
956
AGLAT
961
AGPGL
966
LPRKP
971
PGLAA
976
GPAGT
981
YGKAV
986
SPPPS
991
PRASP
996
VAALK
1001
AKVIQ
1006
KLEDV
1011
SKPPA
1016
YAYPA
1021
TPSSH
1026
PTSPP
1031
PASPP
1036
PTPGI
1041
TRKEE
1046
APENV
1051
VEKKD
1056
LELEK
1061
EAPSP
1066
FQALF
1071
SDIPP
1076
RYPFQ
1081
ALPPH
1086
YGRPY
1091
PFLLQ
1096
PTAAA
1101
DADGL
1106
APDVP
1111
LPADG
1116
PERLA
1121
LSPED
1126
KPIRL
1131
SPSKI
1136
TEPLR
1141
EGPEE
1146
EPLAE
1151
REVKA
1156
EVEDM
1161
DEGPT
1166
ELPPL
1171
ESPLP
1176
LPAAE
1181
AMATP
1186
SPAGG
1191
CGGGL
1196
LEAQA
1201
LSATG
1206
QSCAE
1211
PSECP
1216
DFVEG
1221
PEPRV
1226
DSPGR
1231
TEPCT
1236
AALDL
1241
GVQLT
1246
PETLV
1251
EAKEE
1256
PVEVP
1261
VAVPV
1266
VEAVP
1271
EEGLA
1276
QVAPS
1281
ESQPT
1286
LEMSD
1291
CDVPA
1296
GEGQC
1301
PSLEP
1306
QEAVP
1311
VLGST
1316
CFLEE
1321
ASSDQ
1326
FLPSL
1331
EDPLA
1336
GMNAL
1341
AAAAE
1346
LPQAR
1351
PLPSP
1356
GAAGA
1361
QALEK
1366
LEAAE
1371
SLVLE
1376
QSFLH
1381
GITLL
1386
SEIAE
1391
LELER
1396
RSQEM
1401
GGAER
1406
ALVAR
1411
PSLES
1416
LLAAG
1421
SHMLR
1426
EVLDG
1431
PVVDP
1436
LKNLR
1441
LPREL
1446
KPNKK
1451
YSWMR
1456
KKEER
1461
MYAMK
1466
SSLED
1471
MDALE
1476
LDFRM
1481
RLAEV
1486
QRQYK
1491
EKQRE
1496
LVKLQ
1501
RRRDS
1506
EDRRE
1511
EPHRS
1516
LARRG
1521
PGRPR
1526
KRTHA
1531
PSALS
1536
PPRKR
1541
GKSGH
1546
SSGKL
1551
SSKSL
1556
LTSDD
1561
YELGA
1566
GIRKR
1571
HKGSE
1576
EEHDA
1581
LIGMG
1586
KARGR
1591
NQTWD
1596
EHEAS
1601
SDFIS
1606
QLKIK
1611
KKKMA
1616
SDQEQ
1621
LASKL
1626
DKALS
1631
LTKQD
1636
KLKSP
1641
FKFSD
1646
SAGGK
1651
SKTSG
1656
GCGRY
1661
LTPYD
1666
SLLGK
1671
NRKAL
1676
AKGLG
1681
LSLKS
1686
SREGK
1691
HKRAA
1696
KTRKM
1701
EVGFK
1706
ARGQP
1711
KSAHS
1716
PFASE
1721
VSSYS
1726
YNTDS
1731
EEDEE
1736
FLKDE
1741
WPAQG
1746
PSSSK
1751
LTPSL
1756
LCSMV
1761
AKNSK
1766
AAGGP
1771
KLTKR
1776
GLAAP
1781
RTLKP
1786
KPATS
1791
RKQPF
1796
CLLLR
1801
EAEAR
1806
SSFSD
1811
SSEES
1816
FDQDE
1821
SSEEE
1826
DEEEE
1831
LEEED
1836
EASGG
1841
GYRLG
1846
ARERA
1851
LSPGL
1856
EESGL
1861
GLLAR
1866
FAASA
1871
LPSPT
1876
VGPSL
1881
SVVQL
1886
EAKQK
1891
ARKKE
1896
ERQSL
1901
LGTEF
1906
EYTDS
1911
ESEVK
1916
VRKRS
1921
PAGLL
1926
RPKKG
1931
LGEPG
1936
PSLAA
1941
PTPGA
1946
RGPDP
1951
SSPDK
1956
AKLAV
1961
EKGRK
1966
ARKLR
1971
GPKEP
1976
GFEAG
1981
PEASD
1986
DDLWT
1991
RRRSE
1996
RIFLH
2001
DASAA
2006
APAPV
2011
STAPA
2016
TKTSR
2021
CAKGG
2026
PLSPR
2031
KDAGR
2036
AKDRK
2041
DPRKK
2046
KKGKE
2051
AGPGA
2056
GLPPP
2061
RAPAL
2066
PSEAR
2071
APHAS
2076
SLTAA
2081
KRSKA
2086
KAKGK
2091
EVKKE
2096
NRGKG
2101
GAVSK
2106
LMESM
2111
AAEED
2116
FEPNQ
2121
DSSFS
2126
EDEHL
2131
PRGGA
2136
VERPL
2141
TPAPR
2146
SCIID
2151
KDELK
2156
DGLRV
2161
LIPMD
2166
DKLLY
2171
AGHVQ
2176
TVHSP
2181
DIYRV
2186
VVEGE
2191
RGNRP
2196
HIYCL
2201
EQLLQ
2206
EAIID
2211
VRPAS
2216
TRFLP
2221
QGTRI
2226
AAYWS
2231
QQYRC
2236
LYPGT
2241
VVRGL
2246
LDLED
2251
DGDLI
2256
TVEFD
2261
DGDTG
2266
RIPLS
2271
HIRLL
2276
PPDYK
2281
IQCAE
2286
PSPAL
2291
LVPSA
2296
KRRSR
2301
KTSKD
2306
TGEGK
2311
DGGTA
2316
GSEEP
2321
GAKAR
2326
GRGRK
2331
PSAKA
2336
KGGRA
2341
ATLEE
2346
GNPTD
2351
EVPST
2356
PLALE
2361
PSSTP
2366
GSKKS
2371
PPEPV
2376
DKRAK
2381
APKAR
2386
PAPPQ
2391
PSPAP
2396
PAFTS
2401
CPAPE
2406
PFAEL
2411
PAPAT
2416
SLAPA
2421
PLITM
2426
PATRP
2431
KPKKA
2436
RAAEE
2441
SGAKG
2446
PRRPG
2451
EEAEL
2456
LVKLD
2461
HEGVT
2466
SPKSK
2471
KAKEA
2476
LLLRE
2481
DPGAG
2486
GWQEP
2491
KSLLS
2496
LGSYP
2501
PAAGS
2506
SEPKA
2511
PWPKA
2516
TDGDL
2521
AQEPG
2526
PGLTF
2531
EDSGN
2536
PKSPD
2541
KAQAE
2546
QDGAE
2551
ESESS
2556
SSSSS
2561
GSSSS
2566
SSSSS
2571
SSGSE
2576
TEGEE
2581
EGDKN
2586
GDGGC
2591
GTGGR
2596
NCSAA
2601
SSRAA
2606
SPASS
2611
SSSSS
2616
SSSSS
2621
SSSSS
2626
SSSSS
2631
SSSSS
2636
SSSSS
2641
SSSSS
2646
SSSSS
2651
SSSSS
2656
SSSSS
2661
SSSSS
2666
STTDE
2671
DSSCS
2676
SDDEA
2681
APAPT
2686
AGPSA
2691
QAALP
2696
TKATK
2701
QAGKA
2706
RPSAH
2711
SPGKK
2716
TPAPQ
2721
PQAPP
2726
PQPTQ
2731
PLQPK
2736
AQAGA
2741
KSRPK
2746
KREGV
2751
HLPTT
2756
KELAK
2761
RQRLP
2766
SVENR
2771
PKIAA
2776
FLPAR
2781
QLWKW
2786
FGKPT
2791
QRRGM
2796
KGKAR
2801
KLFYK
2806
AIVRG
2811
KEMIR
2816
IGDCA
2821
VFLSA
2826
GRPNL
2831
PYIGR
2836
IQSMW
2841
ESWGN
2846
NMVVR
2851
VKWFY
2856
HPEET
2861
SPGKQ
2866
FHQGQ
2871
HWDQK
2876
SSRSL
2881
PAALR
2886
VSSQR
2891
KDFME
2896
RALYQ
2901
SSHVD
2906
ENDVQ
2911
TVSHK
2916
CLVVG
2921
LEQYE
2926
QMLKT
2931
KKYQD
2936
SEGLY
2941
YLAGT
2946
YEPTT
2951
GMIFS
2956
TDGVP
2961
VLC
2966
Mutation Information
DNA mutation:
None
Peptide Range:
2572 ~ 2596
Mut AA position:
2584 (13 in Wild Type peptide)
Alignment
Wild Type:
"SSSSSSGSETEGEEEGDKNGDGGCG
||||||||||||.||||||||||||
Mutant:
SSSSSSGSETEGKEEGDKNGDGGCG"
reference

Science, 2015

Immunogenicity of somatic mutations in human gastrointestinal cancers

Gene Name (from Reference) TNRC18

clinic trial
Checkpoint Blockade

None

ACT

None

Vaccination

None

Curative Effect

None

experiment
minimal_peptide

None

Antigen Type

TMG RNA

T-cell Source

TILs

APC Type

None

Assay

IFNg ELISPOT assay