Immunogenicity 1116

summary
Sample ID
3978
Response
Negative
Tumor Type
Bile duct cancer
Gene Symbol
KCNMA1
Transcript ID
ENST00000604624
HLA INFO
DQA*05:01 / DQB*04:02
TCR INFO

No TCR info found!

T cell Tumor cell { DQA*05:01 DQB*04:02
sequence
Full length protein sequence (1042 aa)
GTLKP
1
VDEKE
6
EAVAA
11
EVGWM
16
TSVKD
21
WAGVM
26
ISAQT
31
LTGRV
36
LVVLV
41
FALSI
46
GALVI
51
YFIDS
56
SNPIE
61
SCQNF
66
YKDFT
71
LQIDM
76
AFNVF
81
FLLYF
86
GLRFI
91
AANDK
96
LWFWL
101
EVNSV
106
VDFFT
111
VPPVF
116
VSVYL
121
NRSWL
126
GLRFL
131
RALRL
136
IQFSE
141
ILQFL
146
NILKT
151
SNSIK
156
LVNLL
161
SIFIS
166
TWLTA
171
AGFIH
176
LVENS
181
GDPWE
186
NFQNN
191
QALTY
196
WECVY
201
LLMVT
206
MSTVG
211
YGDVY
216
AKTTL
221
GRLFM
226
VFFIL
231
GGLAM
236
FASYV
241
PEIIE
246
LIGNR
251
KKYGG
256
SYSAV
261
SGRKH
266
IVVCG
271
HITLE
276
SVSNF
281
LKDFL
286
HKDRD
291
DVNVE
296
IVFLH
301
NISPN
306
LELEA
311
LFKRH
316
FTQVE
321
FYQGS
326
VLNPH
331
DLARV
336
KIESA
341
DACLI
346
LANKY
351
CADPD
356
AEDAS
361
NIMRV
366
ISIKN
371
YHPKI
376
RIITQ
381
MLQYH
386
NKAHL
391
LNIPS
396
WNWKE
401
GDDAI
406
CLAEL
411
KLGFI
416
AQSCL
421
AQGLS
426
TMLAN
431
LFSMR
436
SFIKI
441
EEDTW
446
QKYYL
451
EGVSN
456
EMYTE
461
YLSSA
466
FVGLS
471
FPTVC
476
ELCFV
481
KLKLL
486
MIAIE
491
YKSAN
496
RESRS
501
RKRIL
506
INPGN
511
HLKIQ
516
EGTLG
521
FFIAS
526
DAKEV
531
KRAFF
536
YCKAC
541
HDDIT
546
DPKRI
551
KKCGC
556
KRLED
561
EQPST
566
LSPKK
571
KQRNG
576
GMRNS
581
PNTSP
586
KLMRH
591
DPLLI
596
PGNDQ
601
IDNMD
606
SNVKK
611
YDSTG
616
MFHWC
621
APKEI
626
EKVIL
631
TRSEA
636
AMTVL
641
SGHVV
646
VCIFG
651
DVSSA
656
LIGLR
661
NLVMP
666
LRASN
671
FHYHE
676
LKHIV
681
FVGSI
686
EYLKR
691
EWETL
696
HNFPK
701
VSILP
706
GTPLS
711
RADLR
716
AVNIN
721
LCDMC
726
VILSA
731
NQNNI
736
DDTSL
741
QDKEC
746
ILASL
751
NIKSM
756
QFDDS
761
IGVLQ
766
ANSQG
771
FTPPG
776
MDRSS
781
PDNSP
786
VHGML
791
RQPSI
796
TTGVN
801
IPIIT
806
ELVND
811
TNVQF
816
LDQDD
821
DDDPD
826
TELYL
831
TQPFA
836
CGTAF
841
AVSVL
846
DSLMS
851
ATYFN
856
DNILT
861
LIRTL
866
VTGGA
871
TPELE
876
ALIAE
881
ENALR
886
GGYST
891
PQTLA
896
NRDRC
901
RVAQL
906
ALLDG
911
PFADL
916
GDGGC
921
YGDLF
926
CKALK
931
TYNML
936
CFGIY
941
RLRDA
946
HLSTP
951
SQCTK
956
RYVIT
961
NPPYE
966
FELVP
971
TDLIF
976
CLMQF
981
DHNAG
986
QSRAS
991
LSHSS
996
HSSQS
1001
SSKKS
1006
SSVHS
1011
IPSTA
1016
NRQNR
1021
PKSRE
1026
SRDKQ
1031
KKEMV
1036
YR
1041
Mutation Information
DNA mutation:
None
Peptide Range:
96 ~ 120
Mut AA position:
108 (13 in Wild Type peptide)
Alignment
Wild Type:
"AANDKLWFWLEVNSVVDFFTVPPVF
||||||||||||.||||||||||||
Mutant:
AANDKLWFWLEVKSVVDFFTVPPVF"
reference

Science, 2015

Immunogenicity of somatic mutations in human gastrointestinal cancers

Gene Name (from Reference) KCNMA1

clinic trial
Checkpoint Blockade

None

ACT

None

Vaccination

None

Curative Effect

None

experiment
minimal_peptide

None

Antigen Type

TMG RNA

T-cell Source

TILs

APC Type

autologous DCs

Assay

IFNg ELISPOT assay