Immunogenicity 11628
Sample ID
2369
Response
Negative
Tumor Type
Melanoma
Gene Symbol
CNOT1
Transcript ID
uc002enu.4
HLA INFO
A*01:01
TCR INFO
No TCR info found!
Full length protein sequence (2371 aa)
MNLDS
1
LSLAL
6
SQISY
11
LVDNL
16
TKKNY
21
RASQQ
26
EIQHI
31
VNRHG
36
PEADR
41
HLLRC
46
LFSHV
51
DFSGD
56
GKSSG
61
KDFHQ
66
TQFLI
71
QECAL
76
LITKP
81
NFIST
86
LSYAI
91
DNPLH
96
YQKSL
101
KPAPH
106
LFAQL
111
SKVLK
116
LSKVQ
121
EVIFG
126
LALLN
131
SSSSD
136
LRGFA
141
AQFIK
146
QKLPD
151
LLRSY
156
IDADV
161
SGNQE
166
GGFQD
171
IAIEV
176
LHLLL
181
SHLLF
186
GQKGA
191
FGVGQ
196
EQIDA
201
FLKTL
206
RRDFP
211
QERCP
216
VVLAP
221
LLYPE
226
KRDIL
231
MDRIL
236
PDSGG
241
VAKTM
246
MESSL
251
ADFMQ
256
EVGYG
261
FCASI
266
EECRN
271
IIVQF
276
GVREV
281
TAAQV
286
ARVLG
291
MMART
296
HSGLT
301
DGIPL
306
QSISA
311
PGSGI
316
WSDGK
321
DKSDG
326
AQAHT
331
WNVEV
336
LIDVL
341
KELNP
346
SLNFK
351
EVTYE
356
LDHPG
361
FQIRD
366
SKGLH
371
NVVYG
376
IQRGL
381
GMEVF
386
PVDLI
391
YRPWK
396
HAEGQ
401
LSFIQ
406
HSLIN
411
PEIFC
416
FADYP
421
CHTVA
426
TDILK
431
APPED
436
DNREI
441
ATWKS
446
LDLIE
451
SLLRL
456
AEVGQ
461
YEQVK
466
QLFSF
471
PIKHC
476
PDMLV
481
LALLQ
486
INTSW
491
HTLRH
496
ELIST
501
LMPIF
506
LGNHP
511
NSAII
516
LHYAW
521
HGQGQ
526
SPSIR
531
QLIMH
536
AMAEW
541
YMRGE
546
QYDQA
551
KLSRI
556
LDVAQ
561
DLKAL
566
SMLLN
571
GTPFA
576
FVIDL
581
AALAS
586
RREYL
591
KLDKW
596
LTDKI
601
REHGE
606
PFIQA
611
CMTFL
616
KRRCP
621
SILGG
626
LAPEK
631
DQPKS
636
AQLPP
641
ETLAT
646
MLACL
651
QACAG
656
SVSQE
661
LSETI
666
LTMVA
671
NCSNV
676
MNKAR
681
QPPPG
686
VMPKG
691
RPPSA
696
SSLDA
701
ISPVQ
706
IDPLA
711
GMTSL
716
SIGGS
721
AAPHT
726
QSMQG
731
FPPNL
736
GSAFS
741
TPQSP
746
AKAFP
751
PLSTP
756
NQTTA
761
FSGIG
766
GLSSQ
771
LPVGG
776
LGTGS
781
LTGIG
786
TGALG
791
LPAVN
796
NDPFV
801
QRKLG
806
TSGLN
811
QPTFQ
816
QTDLS
821
QVWPE
826
ANQHF
831
SKEID
836
DEANS
841
YFQRI
846
YNHPP
851
HPTMS
856
VDEVL
861
EMLQR
866
FKDST
871
IKRER
876
EVFNC
881
MLRNL
886
FEEYR
891
FFPQY
896
PDKEL
901
HITAC
906
LFGGI
911
IEKGL
916
VTYMA
921
LGLAL
926
RYVLE
931
ALRKP
936
FGSKM
941
YYFGI
946
AALDR
951
FKNRL
956
KDYPQ
961
YCQHL
966
ASISH
971
FMQFP
976
HHLQE
981
YIEYG
986
QQSRD
991
PPVKM
996
QGSIT
1001
TPGSI
1006
ALAQA
1011
QAQAQ
1016
VPAKA
1021
PLAGQ
1026
VSTMV
1031
TTSTT
1036
TTVAK
1041
TVTVT
1046
RPTGV
1051
SFKKD
1056
VPPSI
1061
NTTNI
1066
DTLLV
1071
ATDQT
1076
ERIVE
1081
PPENI
1086
QEKIA
1091
FIFNN
1096
LSQSN
1101
MTQKV
1106
EELKE
1111
TVKEE
1116
FMPWV
1121
SQYLV
1126
MKRVS
1131
IEPNF
1136
HSLYS
1141
NFLDT
1146
LKNPE
1151
FNKMV
1156
LNETY
1161
RNIKV
1166
LLTSD
1171
KAAAN
1176
FSDRS
1181
LLKNL
1186
GHWLG
1191
MITLA
1196
KNKPI
1201
LHTDL
1206
DVKSL
1211
LLEAY
1216
VKGQQ
1221
ELLYV
1226
VPFVA
1231
KVLES
1236
SIRSV
1241
VFRPP
1246
NPWTM
1251
AIMNV
1256
LAELH
1261
QEHDL
1266
KLNLK
1271
FEIEV
1276
LCKNL
1281
ALDIN
1286
ELKPG
1291
NLLKD
1296
KDRLK
1301
NLDEQ
1306
LSAPK
1311
KDVKQ
1316
PEELP
1321
PITTT
1326
TTSTT
1331
PATNT
1336
TCTAT
1341
VPPQP
1346
QYSYH
1351
DINVY
1356
SLAGL
1361
APHIT
1366
LNPTI
1371
PLFQA
1376
HPQLK
1381
QCVRQ
1386
AIERA
1391
VQELV
1396
HPVVD
1401
RSIKI
1406
AMTTC
1411
EQIVR
1416
KDFAL
1421
DSEES
1426
RMRIA
1431
AHHMM
1436
RNLTA
1441
GMAMI
1446
TCREP
1451
LLMSI
1456
STNLK
1461
NSFAS
1466
ALRTA
1471
SPQQR
1476
EMMDQ
1481
AAAQL
1486
AQDNC
1491
ELACC
1496
FIQKT
1501
AVEKA
1506
GPEMD
1511
KRLAT
1516
EFELR
1521
KHARQ
1526
EGRRY
1531
CDPVV
1536
LTYQA
1541
ERMPE
1546
QIRLK
1551
VGGVD
1556
PKQLA
1561
VYEEF
1566
ARNVP
1571
GFLPT
1576
NDLSQ
1581
PTGFL
1586
AQPMK
1591
QAWAT
1596
DDVAQ
1601
IYDKC
1606
ITELE
1611
QHLHA
1616
IPPTL
1621
AMNPQ
1626
AQALR
1631
SLLEV
1636
VVLSR
1641
NSRDA
1646
IAALG
1651
LLQKA
1656
VEGLL
1661
DATSG
1666
ADADL
1671
LLRYR
1676
ECHLL
1681
VLKAL
1686
QDGRA
1691
YGSPW
1696
CNKQI
1701
TRCLI
1706
ECRDE
1711
YKYNV
1716
EAVEL
1721
LIRNH
1726
LVNMQ
1731
QYDLH
1736
LAQSM
1741
ENGLN
1746
YMAVA
1751
FAMQL
1756
VKILL
1761
VDERS
1766
VAHVT
1771
EADLF
1776
HTIET
1781
LMRIN
1786
AHSRG
1791
NAPEG
1796
LPQLM
1801
EVVRS
1806
NYEAM
1811
IDRAH
1816
GGPNF
1821
MMHSG
1826
ISQAS
1831
EYDDP
1836
PGLRE
1841
KAEYL
1846
LREWV
1851
NLYHS
1856
AAAGR
1861
DSTKA
1866
FSAFV
1871
GQMHQ
1876
QGILK
1881
TDDLI
1886
TRFFR
1891
LCTEM
1896
CVEIS
1901
YRAQA
1906
EQQHN
1911
PAANP
1916
TMIRA
1921
KCYHN
1926
LDAFV
1931
RLIAL
1936
LVKHS
1941
GEATN
1946
TVTKI
1951
NLLNK
1956
VLGIV
1961
VGVLL
1966
QDHDV
1971
RQSEF
1976
QQLPY
1981
HRIFI
1986
MLLLE
1991
LNAPE
1996
HVLET
2001
INFQT
2006
LTAFC
2011
NTFHI
2016
LRPTK
2021
APGFV
2026
YAWLE
2031
LISHR
2036
IFIAR
2041
MLAHT
2046
PQQKG
2051
WPMYA
2056
QLLID
2061
LFKYL
2066
APFLR
2071
NVELT
2076
KPMQI
2081
LYKGT
2086
LRVLL
2091
VLLHD
2096
FPEFL
2101
CDYHY
2106
GFCDV
2111
IPPNC
2116
IQLRN
2121
LILSA
2126
FPRNM
2131
RLPDP
2136
FTPNL
2141
KVDML
2146
SEINI
2151
APRIL
2156
TNFTG
2161
VMPPQ
2166
FKKDL
2171
DSYLK
2176
TRSPV
2181
TFLSD
2186
LRSNL
2191
QVSNE
2196
PGNRY
2201
NLQLI
2206
NALVL
2211
YVGTQ
2216
AIAHI
2221
HNKGS
2226
TPSMS
2231
TITHS
2236
AHMDI
2241
FQNLA
2246
VDLDT
2251
EGRYL
2256
FLNAI
2261
ANQLR
2266
YPNSH
2271
THYFS
2276
CTMLY
2281
LFAEA
2286
NTEAI
2291
QEQIT
2296
RVLLE
2301
RLIVN
2306
RPHPW
2311
GLLIT
2316
FIELI
2321
KNPAF
2326
KFWNH
2331
EFVHC
2336
APEIE
2341
KLFQS
2346
VAQCC
2351
MGQKQ
2356
AQQVM
2361
EGTGA
2366
S
2371
Mutation Information
DNA mutation:
c.659G>A
Peptide Range:
220 ~ 228
Mut AA position:
220 (1 in Wild Type peptide)
Alignment
Wild Type:
"PVVLAPLLY
.||||||||
Mutant:
LVVLAPLLY"
Nat Med, 2013
Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cellsGene Name (from Reference) CNOT1
Checkpoint
Blockade
None
ACT
None
Vaccination
None
Curative
Effect
None
minimal_peptide
None
Antigen
Type
peptide
T-cell
Source
TILs
APC
Type
HEK293 cells
Assay
IFNg ELISPOT assay