Immunogenicity 1256
Sample ID
3971
Response
Negative
Tumor Type
Colon cancer
Gene Symbol
FAM186A
Transcript ID
ENST00000327337
HLA INFO
C*01:02
TCR INFO
No TCR info found!
Full length protein sequence (2351 aa)
MFFKM
1
KNEID
6
NDPES
11
EKCIK
16
DSTIM
21
RREPQ
26
NILSP
31
LMLPN
36
LEIPF
41
SVKDI
46
ISRIE
51
RAQLH
56
RARED
61
IDMQL
66
SEIMN
71
NVHRI
76
MTRYT
81
LVFNS
86
SSERN
91
VSLTE
96
HKKKQ
101
RTNFL
106
EKMAT
111
YAKTI
116
EIREK
121
TLANI
126
LAWLE
131
EWNDV
136
LSEMT
141
LMDVD
146
EHHHW
151
IAQME
156
LLPDT
161
LKAIE
166
NNVKI
171
LSRFS
176
TSFLD
181
EKKKQ
186
KKKIL
191
SRGTL
196
WKSWK
201
ERVIK
206
RPSTA
211
RALRP
216
DQMIS
221
DQLAT
226
NTKVS
231
EIQGM
236
LQELI
241
GTTMF
246
STLEN
251
NAIKY
256
ISSTI
261
VNLST
266
ALSML
271
NDELK
276
CVNFQ
281
SSTVY
286
AHETS
291
EAEKE
296
LSLKI
301
IRDLS
306
NENEM
311
LQQKL
316
QDAEE
321
KCEQL
326
IRSKI
331
VIEQL
336
YAKLS
341
TSSTL
346
KVLPG
351
PSPQS
356
SRAII
361
KVGDT
366
EDNMD
371
NILDK
376
ELENI
381
VDEVQ
386
RKETK
391
DSGIK
396
WDSTI
401
SYTAQ
406
AERTP
411
DLTEL
416
RQQPV
421
ASEDI
426
SEDST
431
KDNVS
436
LKKGD
441
FYQED
446
ETDEY
451
QSWKR
456
SHKKA
461
TYVYE
466
TSGPN
471
LSDNK
476
SGQKV
481
SEAKP
486
SQYYE
491
LQVLK
496
KKRKE
501
MKSFS
506
EDKSK
511
SPTEA
516
KRKHL
521
SLTET
526
KSQGG
531
KSGTS
536
MMMLE
541
QFRKV
546
KRESP
551
FDKRP
556
TAAEI
561
KVEPT
566
TESLD
571
KEGKG
576
EIRSL
581
VEPLS
586
MIQFD
591
DTAEP
596
QKGKI
601
KGKKH
606
HISSG
611
TITSK
616
EEKTE
621
EKEEL
626
TKQVK
631
SHQLV
636
KSLSR
641
VAKET
646
SESTR
651
VLESP
656
DGKSE
661
QSNLE
666
EFQEA
671
IMAFL
676
KQKID
681
NIGKA
686
FDKKT
691
VPKEE
696
ELLKR
701
AEAEK
706
LGIIK
711
AKMEE
716
YFQKV
721
AETVT
726
KILRK
731
YKDTK
736
KEEQV
741
GEKPI
746
KQKKV
751
VSFMP
756
GLHFQ
761
KSPIS
766
AKSES
771
STLLS
776
YESTD
781
PVINN
786
LIQMI
791
LAEIE
796
SERDI
801
PTVST
806
VQKDH
811
KEKEK
816
QRQEQ
821
YLQEG
826
QEQMS
831
GMSLK
836
QQLLG
841
ERNLL
846
KEHYE
851
KISEN
856
WEEKK
861
AWLQM
866
KEGKQ
871
EQQSQ
876
KQWQE
881
EEMWK
886
EEQKQ
891
ATPKQ
896
AEQEE
901
KQKQR
906
GQEEE
911
ELPKS
916
SLQRL
921
EEGTQ
926
KMKTQ
931
GLLLE
936
KENGQ
941
MRQIQ
946
KEAKH
951
LGPHR
956
RREKG
961
KEKQK
966
PERGL
971
EDLER
976
QIKTK
981
DQMQM
986
KETQP
991
KELEK
996
MVIQT
1001
PMTLS
1006
PRWKS
1011
VLKDV
1016
QRSYE
1021
GKEFQ
1026
RNLKT
1031
LENLP
1036
DEKEP
1041
ISITP
1046
PPSLQ
1051
YSLPG
1056
ALPIS
1061
GQPLT
1066
KCIHL
1071
TPQQA
1076
QEVGI
1081
TLTPQ
1086
QAQAQ
1091
GITLT
1096
LQQAQ
1101
ELGIP
1106
LTPQQ
1111
AQALE
1116
ILFTP
1121
QQAQA
1126
LGIPL
1131
TPQQT
1136
QVQGI
1141
TLTPQ
1146
QDQAP
1151
GISLT
1156
TQQAQ
1161
KLGIP
1166
LTPQQ
1171
AQALG
1176
IPLTP
1181
QQAQE
1186
LGIPL
1191
TPQQA
1196
QALRV
1201
SLTPQ
1206
QAQEL
1211
GIPLT
1216
PQQAQ
1221
ALGIT
1226
LTLQQ
1231
AQQLG
1236
IPLTP
1241
QQAQA
1246
LGITL
1251
TPKQV
1256
QELGI
1261
PLTPQ
1266
QAQAL
1271
GITLT
1276
PKQAQ
1281
ELGIP
1286
LNPQQ
1291
AQTLG
1296
IPLTP
1301
KQAQA
1306
LGIPF
1311
TPQQA
1316
QALGI
1321
PLTPQ
1326
QAQTQ
1331
EITLT
1336
PQQAQ
1341
ALGMP
1346
LTTQQ
1351
AQELG
1356
IPLTP
1361
QHAQA
1366
LGMPL
1371
TTQQA
1376
QELGI
1381
PLTPQ
1386
QAQAL
1391
GMPLT
1396
TQQAQ
1401
ELGIP
1406
LTPQQ
1411
AQELG
1416
IPFTP
1421
QQAQA
1426
QEITL
1431
TPQQA
1436
QALGM
1441
PLTAQ
1446
QAQEL
1451
GITLT
1456
PQQAQ
1461
ELGIP
1466
LTPQQ
1471
AQALG
1476
IPLIP
1481
PQAQE
1486
LGIPL
1491
TPQQA
1496
QALGI
1501
LLIPP
1506
QAQEL
1511
GIPLT
1516
PQQAQ
1521
ALGIP
1526
LIPPQ
1531
AQELG
1536
IPLTP
1541
QQVQA
1546
LGIPL
1551
IPPQA
1556
QELEI
1561
PLTPQ
1566
QAQAL
1571
GIPLT
1576
PQQAQ
1581
ELGIP
1586
LTPQQ
1591
AQELG
1596
IPLTP
1601
QQAQA
1606
QGIPL
1611
TPQQA
1616
QALGI
1621
SLTPQ
1626
QAQAQ
1631
GITLT
1636
PQQAQ
1641
ALGVP
1646
ITPVN
1651
AWVSA
1656
VTLTS
1661
EQTHA
1666
LESPM
1671
NLEQA
1676
QEQLL
1681
KLGVP
1686
LTLDK
1691
AHTLG
1696
SPLTL
1701
KQVQW
1706
SHRPF
1711
QKSKA
1716
SLPTG
1721
QSIIS
1726
RLSPS
1731
LRLSL
1736
ASSAP
1741
TAEKS
1746
SIFGV
1751
SSTPL
1756
QISRV
1761
PLNQG
1766
PFAPG
1771
KPLEM
1776
GILSE
1781
PGKLG
1786
APQTL
1791
RSSGQ
1796
TLVYG
1801
GQSTS
1806
AQFPA
1811
PQAPP
1816
SPGQL
1821
PISRA
1826
PPTPG
1831
QPFIA
1836
GVPPT
1841
SGQIP
1846
SLWAP
1851
LSPGQ
1856
PLVPE
1861
ASSIP
1866
GDLLE
1871
SGPLT
1876
FSEQL
1881
QEFQP
1886
PATAE
1891
QSPYL
1896
QAPST
1901
PGQHL
1906
ATWTL
1911
PGRAS
1916
SLWIP
1921
PTSRH
1926
PPTLW
1931
PSPAP
1936
GKPQK
1941
SWSPS
1946
VAKKR
1951
LAIIS
1956
SLKSK
1961
SVLIH
1966
PSAPD
1971
FKVAQ
1976
VPFTT
1981
KKFQM
1986
SEVSD
1991
TSEET
1996
QILRD
2001
TFAIE
2006
SFRTF
2011
QSHFT
2016
KYRTP
2021
VYQTP
2026
YTDER
2031
ALLTL
2036
MKPTT
2041
SPSSL
2046
TTLLR
2051
TSQIS
2056
PLEWY
2061
QKSRF
2066
PPIDK
2071
PWILS
2076
SVSDT
2081
KKPKV
2086
MVPPS
2091
SPQEL
2096
EEKRY
2101
FVDVE
2106
AQKKN
2111
LILLN
2116
QAIKT
2121
CGLPS
2126
QLHTM
2131
ARTLI
2136
IEILH
2141
MDTVQ
2146
LGYLF
2151
RKYIA
2156
YRLIQ
2161
HARNN
2166
IMKRL
2171
KAIQN
2176
TGKGY
2181
EARNL
2186
HMMLS
2191
RLDDY
2196
GKKVM
2201
QVWTE
2206
KQKSL
2211
GQKRN
2216
QCLKK
2221
MIHVF
2226
NQLKK
2231
IHELN
2236
LSQPI
2241
PLIIE
2246
EKQIP
2251
ASTTF
2256
VQKPF
2261
LKLLM
2266
EEDRT
2271
SDICK
2276
KFRQQ
2281
EDQTE
2286
AIWNV
2291
DLSTS
2296
SYPIA
2301
EKTSM
2306
HSLWA
2311
QLGGY
2316
PDIPR
2321
LLQLE
2326
VQSTF
2331
RKSLA
2336
SLQSR
2341
VKKIP
2346
K
2351
Mutation Information
DNA mutation:
None
Peptide Range:
1536 ~ 1560
Mut AA position:
1548 (13 in Wild Type peptide)
Alignment
Wild Type:
"AQELGIPLTPQQVQALGIPLIPPQA
||||||||||||.||||||||||||
Mutant:
AQELGIPLTPQQAQALGIPLIPPQA"
Science, 2015
Immunogenicity of somatic mutations in human gastrointestinal cancersGene Name (from Reference) FAM186A
Checkpoint
Blockade
None
ACT
None
Vaccination
None
Curative
Effect
None
minimal_peptide
None
Antigen
Type
TMG RNA
T-cell
Source
TILs
APC
Type
autologous DCs
Assay
IFNg ELISPOT assay