Immunogenicity 13447
Sample ID
3926
Response
Negative
Tumor Type
Melanoma
Gene Symbol
DROSHA
Transcript ID
uc003jhi.2
HLA INFO
B*13:02
TCR INFO
No TCR info found!
Full length protein sequence (1185 aa)
MMQGN
1
TCHRM
6
SFHPG
11
RGCPR
16
GRGGH
21
GARPS
26
APSFR
31
PQNLR
36
LLHPQ
41
QPPVQ
46
YQYEP
51
PSAPS
56
TTFSN
61
SPAPN
66
FLPPR
71
PDFVP
76
FPPPM
81
PPSAQ
86
GPLPP
91
CPIRP
96
PFPNH
101
QMRHP
106
FPVPP
111
CFPPM
116
PPPMP
121
CPNNP
126
PVPGA
131
PPGQG
136
TFPFM
141
MPPPS
146
MPHPP
151
PPPVM
156
PQQVN
161
YQYPP
166
GYSHH
171
NFPPP
176
SFNSF
181
QNNPS
186
SFLPS
191
ANNSS
196
SPHFR
201
HLPPY
206
PLPKA
211
PSERR
216
SPERL
221
KHYDD
226
HRHRD
231
HSHGR
236
GERHR
241
SLDRR
246
ERGRS
251
PDRRR
256
QDSRY
261
RSDYD
266
RGRTP
271
SRHRS
276
YERSR
281
ERERE
286
RHRHR
291
DNRRS
296
PSLER
301
SYKKE
306
YKRSG
311
SRSPS
316
REKKR
321
ARWEE
326
EKDRW
331
SDNQS
336
SGKDK
341
NYTSI
346
KEKEP
351
EETMP
356
DKNEE
361
EEEEL
366
LKPVW
371
IRCTH
376
SENYY
381
SSDPM
386
DQVGD
391
STVVG
396
TSRLR
401
DLYDK
406
FEEEL
411
GSRQE
416
KAKAA
421
RPPWE
426
PPKTK
431
LDEDL
436
ESSSE
441
SECES
446
DEDST
451
CSSSS
456
DSEVF
461
DVIAE
466
IKRKK
471
AHPDR
476
LHDEL
481
WYNDP
486
GQMND
491
GPLCK
496
CSAKA
501
RRTGI
506
RHSIY
511
PGEEA
516
IKPCR
521
PMTNN
526
AGRLF
531
HYRIT
536
VSPPT
541
NFLTD
546
RPTVI
551
EYDDH
556
EYIFE
561
GFSMF
566
AHAPL
571
TNIPL
576
CKVIR
581
FNIDY
586
TIHFI
591
EEMMP
596
ENFCV
601
KGLEL
606
FSLFL
611
FRDIL
616
ELYDW
621
NLKGP
626
LFEDS
631
PPCCP
636
RFHFM
641
PRFVR
646
FLPDG
651
GKEVL
656
SMHQI
661
LLYLL
666
RCSKA
671
LVPEE
676
EIANM
681
LQWEE
686
LEWQK
691
YAEEC
696
KGMIV
701
TNPGT
706
KPSSV
711
RIDQL
716
DREQF
721
NPDVI
726
TFPII
731
VHFGI
736
RPAQL
741
SYAGD
746
PQYQK
751
LWKSY
756
VKLRH
761
LLANS
766
PKVKQ
771
TDKQK
776
LAQRE
781
EALQK
786
IRQKN
791
TMRRE
796
VTVEL
801
SSQGF
806
WKTGI
811
RSDVC
816
QHAMM
821
LPVLT
826
HHIRY
831
HQCLM
836
HLDKL
841
IGYTF
846
QDRCL
851
LQLAM
856
THPSH
861
HLNFG
866
MNPDH
871
ARNSL
876
SNCGI
881
RQPKY
886
GDRKV
891
HHMHM
896
RKKGI
901
NTLIN
906
IMSRL
911
GQDDP
916
TPSRI
921
NHNER
926
LEFLG
931
DAVVE
936
FLTSV
941
HLYYL
946
FPSLE
951
EGGLA
956
TYRTA
961
IVQNQ
966
HLAML
971
AKKLE
976
LDRFM
981
LYAHG
986
PDLCR
991
ESDLR
996
HAMAN
1001
CFEAL
1006
IGAVY
1011
LEGSL
1016
EEAKQ
1021
LFGRL
1026
LFNDP
1031
DLREV
1036
WLNYP
1041
LHPLQ
1046
LQEPN
1051
TDRQL
1056
IETSP
1061
VLQKL
1066
TEFEE
1071
AIGVI
1076
FTHVR
1081
LLARA
1086
FTLRT
1091
VGFNH
1096
LTLGH
1101
NQRME
1106
FLGDS
1111
IMQLV
1116
ATEYL
1121
FIHFP
1126
DHHEG
1131
HLTLL
1136
RSSLV
1141
NNRTQ
1146
AKVAE
1151
ELGMQ
1156
EYAIT
1161
NDKTK
1166
RPVAL
1171
RTKTL
1176
ADLLE
1181
Mutation Information
DNA mutation:
None
Peptide Range:
910 ~ 934
Mut AA position:
922 (13 in Wild Type peptide)
Alignment
Wild Type:
"NIMSRLGQDDPTPSRINHNERLEFL
||||||||||||.||||||||||||
Mutant:
NIMSRLGQDDPTLSRINHNERLEFL"
Nat Med, 2016
Prospective identification of neoantigen-specific lymphocytes in the peripheral blood of melanoma patientsGene Name (from Reference) DROSHA
Checkpoint
Blockade
None
ACT
None
Vaccination
None
Curative
Effect
None
minimal_peptide
None
Antigen
Type
TMG RNA
T-cell
Source
PBMCs
APC
Type
autologous DCs
Assay
IFNg ELISPOT assay