Immunogenicity 13690
Sample ID
3998
Response
Negative
Tumor Type
Melanoma
Gene Symbol
NPC1L1
Transcript ID
uc011kbw.2
HLA INFO
B*18:01
TCR INFO
No TCR info found!
Full length protein sequence (1286 aa)
MAEAG
1
LRGWL
6
LWALL
11
LRLAQ
16
SEPYT
21
TIHQP
26
GYCAF
31
YDECG
36
KNPEL
41
SGSLM
46
TLSNV
51
SCLSN
56
TPARK
61
ITGDH
66
LILLQ
71
KICPR
76
LYTGP
81
NTQAC
86
CSAKQ
91
LVSLE
96
ASLSI
101
TKALL
106
TRCPA
111
CSDNF
116
VNLHC
121
HNTCS
126
PNQSL
131
FINVT
136
RVAQL
141
GAGQL
146
PAVVA
151
YEAFY
156
QHSFA
161
EQSYD
166
SCSRV
171
RVPAA
176
ATLAV
181
GTMCG
186
VYGSA
191
LCNAQ
196
RWLNF
201
QGDTG
206
NGLAP
211
LDITF
216
HLLEP
221
GQAVG
226
SGIQP
231
LNEGV
236
ARCNE
241
SQGDD
246
VATCS
251
CQDCA
256
ASCPA
261
IARPQ
266
ALDST
271
FYLGQ
276
MPGSL
281
VLIII
286
LCSVF
291
AVVTI
296
LLVGF
301
RVAPA
306
RDKSK
311
MVDPK
316
KGTSL
321
SDKLS
326
FSTHT
331
LLGQF
336
FQGWG
341
TWVAS
346
WPLTI
351
LVLSV
356
IPVVA
361
LAAGL
366
VFTEL
371
TTDPV
376
ELWSA
381
PNSQA
386
RSEKA
391
FHDQH
396
FGPFF
401
RTNQV
406
ILTAP
411
NRSSY
416
RYDSL
421
LLGPK
426
NFSGI
431
LDLDL
436
LLELL
441
ELQER
446
LRHLQ
451
VWSPE
456
AQRNI
461
SLQDI
466
CYAPL
471
NPDNT
476
SLYDC
481
CINSL
486
LQYFQ
491
NNRTL
496
LLLTA
501
NQTLM
506
GQTSQ
511
VDWKD
516
HFLYC
521
ANAPL
526
TFKDG
531
TALAL
536
SCMAD
541
YGAPV
546
FPFLA
551
IGGYK
556
GKDYS
561
EAEAL
566
IMTFS
571
LNNYP
576
AGDPR
581
LAQAK
586
LWEEA
591
FLEEM
596
RAFQR
601
RMAGM
606
FQVTF
611
MAERS
616
LEDEI
621
NRTTA
626
EDLPI
631
FATSY
636
IVIFL
641
YISLA
646
LGSYS
651
SWSRV
656
MVDSK
661
ATLGL
666
GGVAV
671
VLGAV
676
MAAMG
681
FFSYL
686
GIRSS
691
LVILQ
696
VVPFL
701
VLSVG
706
ADNIF
711
IFVLE
716
YQRLP
721
RRPGE
726
PREVH
731
IGRAL
736
GRVAP
741
SMLLC
746
SLSEA
751
ICFFL
756
GALTP
761
MPAVR
766
TFALT
771
SGLAV
776
ILDFL
781
LQMSA
786
FVALL
791
SLDSK
796
RQEAS
801
RLDVC
806
CCVKP
811
QELPP
816
PGQGE
821
GLLLG
826
FFQKA
831
YAPFL
836
LHWIT
841
RGVVV
846
GAPVY
851
FVTTL
856
GYNFS
861
SEAGM
866
NAICS
871
SAGCN
876
NFSFT
881
QKIQY
886
ATEFP
891
EQSYL
896
AIPAS
901
SWVDD
906
FIDWL
911
TPSSC
916
CRLYI
921
SGPNK
926
DKFCP
931
STVNS
936
LNCLK
941
NCMSI
946
TMGSV
951
RPSVE
956
QFHKY
961
LPWFL
966
NDRPN
971
IKCPK
976
GGLAA
981
YSTSV
986
NLTSD
991
GQVLA
996
SRFMA
1001
YHKPL
1006
KNSQD
1011
YTEAL
1016
RAARE
1021
LAANI
1026
TADLR
1031
KVPGT
1036
DPAFE
1041
VFPYT
1046
ITNVF
1051
YEQYL
1056
TILPE
1061
GLFML
1066
SLCLV
1071
PTFAV
1076
SCLLL
1081
GLDLR
1086
SGLLN
1091
LLSIV
1096
MILVD
1101
TVGFM
1106
ALWGI
1111
SYNAV
1116
SLINL
1121
VSAVG
1126
MSVEF
1131
VSHIT
1136
RSFAI
1141
STKPT
1146
WLERA
1151
KEATI
1156
SMGSA
1161
VFAGV
1166
AMTNL
1171
PGILV
1176
LGLAK
1181
AQLIQ
1186
IFFFR
1191
LNLLI
1196
TLLGL
1201
LHGLV
1206
FLPVI
1211
LSYVG
1216
PDVNP
1221
ALALE
1226
QKRAE
1231
EAVAA
1236
VMVAS
1241
CPNHP
1246
SRVST
1251
ADNIY
1256
VNHSF
1261
EGSIK
1266
GAGAI
1271
SNFLP
1276
NNGRQ
1281
F
1286
Mutation Information
DNA mutation:
None
Peptide Range:
447 ~ 471
Mut AA position:
459 (13 in Wild Type peptide)
Alignment
Wild Type:
"LQERLRHLQVWSPEAQRNISLQDIC
||||||||||||.||||||||||||
Mutant:
LQERLRHLQVWSLEAQRNISLQDIC"
Nat Med, 2016
Prospective identification of neoantigen-specific lymphocytes in the peripheral blood of melanoma patientsGene Name (from Reference) NPC1L1
Checkpoint
Blockade
None
ACT
None
Vaccination
None
Curative
Effect
None
minimal_peptide
None
Antigen
Type
TMG RNA
T-cell
Source
PBMCs
APC
Type
COS7
Assay
IFNg ELISPOT assay