Immunogenicity 15343
Sample ID
4095
Response
Negative
Tumor Type
Colorectal cancer
Gene Symbol
AKAP6 (FPKM: 0.34)
Transcript ID
ENST00000280979
HLA INFO
A*02:01
TCR INFO
No TCR info found!
Full length protein sequence (2319 aa)
MLTMS
1
VTLSP
6
LRSQD
11
LDPMA
16
TDASP
21
MAINM
26
TPTVE
31
QGEGE
36
EAMKD
41
MDSDQ
46
QYEKP
51
PPLHT
56
GADWK
61
IVLHL
66
PEIET
71
WLRMT
76
SERVR
81
DLTYS
86
VQQDS
91
DSKHV
96
DVHLV
101
QLKDI
106
CEDIS
111
DHVEQ
116
IHALL
121
ETEFS
126
LKLLS
131
YSVNV
136
IVDIH
141
AVQLL
146
WHQLR
151
VSVLV
156
LRERI
161
LQGLQ
166
DANGN
171
YTRQT
176
DILQA
181
FSEET
186
KEGRL
191
DSLTE
196
VDDSG
201
QLTIK
206
CSQNY
211
LSLDC
216
GITAF
221
ELSDY
226
SPSED
231
LLSGL
236
GDMTS
241
SQVKT
246
KPFDS
251
WSYSE
256
MEKEF
261
PELIR
266
SVGLL
271
TVAAD
276
SISTN
281
GSEAV
286
TEEVS
291
QVSLS
296
VDDKG
301
GCEED
306
NASAV
311
EEQPG
316
LTLGV
321
SSSSG
326
EALTN
331
AAQPS
336
SETVQ
341
QESSS
346
SSHHD
351
AKNQQ
356
PVPCE
361
NATPK
366
RTIRD
371
CFNYN
376
EDSPT
381
QPTLP
386
KRGLF
391
LKEET
396
FKNDL
401
KGNGG
406
KRQMV
411
DLKPE
416
MSRST
421
PSLVD
426
PPDRS
431
KLCLV
436
LQSSY
441
PNSPS
446
AASQS
451
YECLH
456
KVGNG
461
NLENT
466
VKFHI
471
KEISS
476
SLGRL
481
NDCYK
486
EKSRL
491
KKPHK
496
TSEEV
501
PPCRT
506
PKRGT
511
GSGKQ
516
AKNTK
521
SSAVP
526
NGELS
531
YTSKA
536
IEGPQ
541
TNSAS
546
TSSLE
551
PCNQR
556
SWNAK
561
LQLQS
566
ETSSS
571
PAFTQ
576
SSESS
581
VGSDN
586
IMSPV
591
PLLSK
596
HKSKK
601
GQASS
606
PSHVT
611
RNGEV
616
VEAWY
621
GSDEY
626
LALPS
631
HLKQT
636
EVLAL
641
KLENL
646
TKLLP
651
QKPRG
656
ETIQN
661
IDDWE
666
LSEMN
671
SDSEI
676
YPTYH
681
VKKKH
686
TRLGR
691
VSPSS
696
SSDIA
701
SSLGE
706
SIESG
711
PLSDI
716
LSDEE
721
SSMPL
726
AGMKK
731
YADEK
736
SERAS
741
SSEKN
746
ESHSA
751
TKSAL
756
IQKLM
761
QDIQH
766
QDNYE
771
AIWEK
776
IEGFV
781
NKLDE
786
FIQWL
791
NEAME
796
TTENW
801
TPPKA
806
EMDDL
811
KLYLE
816
THLSF
821
KLNVD
826
SHCAL
831
KEAVE
836
EEGHQ
841
LLELI
846
ASHKA
851
GLKDM
856
LRMIA
861
SQWKE
866
LQRQI
871
KRQHS
876
WILRA
881
LDTIK
886
AEILA
891
TDVSV
896
EDEEG
901
TGSPK
906
AEVQL
911
CYLEA
916
QRDAV
921
EQMSL
926
KLYSE
931
QYTSS
936
SKRKE
941
EFADM
946
SKVHS
951
VGSNG
956
LLDFD
961
SEYQE
966
LWDWL
971
IDMES
976
LVMDS
981
HDLMM
986
SEEQQ
991
QHLYK
996
RYSVE
1001
MSIRH
1006
LKKTE
1011
LLSKV
1016
EALKK
1021
GGVLL
1026
PNDLL
1031
EKVDS
1036
INEKW
1041
ELLGK
1046
TLGEK
1051
IQDTM
1056
AGHSG
1061
SSPRD
1066
LLSPE
1071
SGSLV
1076
RQLEV
1081
RIKEL
1086
KGWLR
1091
DTELF
1096
IFNSC
1101
LRQEK
1106
EGTMN
1111
TEKQL
1116
QYFKS
1121
LCREI
1126
KQRRR
1131
GVASI
1136
LRLCQ
1141
HLLDD
1146
RETCN
1151
LNADH
1156
QPMQL
1161
IIVNL
1166
ERRWE
1171
AIVMQ
1176
AVQWQ
1181
TRLQK
1186
KMGKE
1191
SETLN
1196
VIDPG
1201
LMDLN
1206
GMSED
1211
ALEWD
1216
EMDIS
1221
NKLIS
1226
LNEES
1231
NDLDQ
1236
ELQPV
1241
IPSLK
1246
LGETS
1251
NEDPG
1256
YDEEA
1261
DNHGG
1266
SQYAS
1271
NITAP
1276
SSPHI
1281
YQVYS
1286
LHNVE
1291
LYEDN
1296
HMPFL
1301
KNNPK
1306
VTGMT
1311
QPNVL
1316
TKSLS
1321
KDSSF
1326
SSTKS
1331
LPDLL
1336
GGSNL
1341
VKPCA
1346
CHGGD
1351
MSQNS
1356
GSESG
1361
IVSEG
1366
DTETT
1371
TNSEM
1376
CLLNA
1381
VDGSP
1386
SNLET
1391
EHLDP
1396
QMGDA
1401
VNVLK
1406
QKFTD
1411
EGESI
1416
KLPNS
1421
SQSSI
1426
SPVGC
1431
VNGKV
1436
GDLNS
1441
ITKHT
1446
PDCLG
1451
EELQG
1456
KHDVF
1461
TFYDY
1466
SYLQG
1471
SKLKL
1476
PMIMK
1481
QSQSE
1486
KAHVE
1491
DPLLR
1496
GFYFD
1501
KKSCK
1506
SKHQT
1511
TELQP
1516
DVPPH
1521
ERILA
1526
SASHE
1531
MDRIS
1536
YKSGN
1541
IEKTF
1546
TGMQN
1551
AKQLS
1556
LLSHS
1561
SSIES
1566
LSPGG
1571
DLFGL
1576
GIFKN
1581
GSDSL
1586
QRSTS
1591
LESWL
1596
TSYKS
1601
NEDLF
1606
SCHSS
1611
GDISV
1616
SSGSV
1621
GELSK
1626
RTLDL
1631
LNRLE
1636
NIQSP
1641
SEQKI
1646
KRSVS
1651
DITLQ
1656
SSSQK
1661
MSFTG
1666
QMSLD
1671
IASSI
1676
NEDSA
1681
ASLTE
1686
LSSSD
1691
ELSLC
1696
SEDIV
1701
LHKNK
1706
IPESN
1711
ASFRK
1716
RLTRS
1721
VADES
1726
DVNVS
1731
MIVNV
1736
SCTSA
1741
CTDDE
1746
DDSDL
1751
LSSST
1756
LTLTE
1761
EELCI
1766
KDEDD
1771
DSSIA
1776
TDDEI
1781
YEDCT
1786
LMSGL
1791
DYIKN
1796
ELQTW
1801
IRPKL
1806
SLTRD
1811
KKRCN
1816
VSDEM
1821
KGSKD
1826
ISSSE
1831
MTNPS
1836
DTLNI
1841
ETLLN
1846
GSVKR
1851
VSENN
1856
GNGKN
1861
SSHTH
1866
ELGTK
1871
RENKK
1876
TIFKV
1881
NKDPY
1886
VADME
1891
NGNIE
1896
GIPER
1901
QKGKP
1906
NVTSK
1911
VSENL
1916
GSHGK
1921
EISES
1926
EHCKC
1931
KALMD
1936
SLDDS
1941
NTAGK
1946
EFVSQ
1951
DVRHL
1956
PKKCP
1961
NHHHF
1966
ENQST
1971
ASTPT
1976
EKSFS
1981
ELALE
1986
TRFNN
1991
RQDSD
1996
ALKSS
2001
DDAPS
2006
MAGKS
2011
AGCCL
2016
ALEQN
2021
GTEEN
2026
ASISN
2031
ISCCN
2036
CEPDV
2041
FHQKD
2046
AEDCS
2051
VHNFV
2056
KEIID
2061
MASTA
2066
LKSKS
2071
QPENE
2076
VAAPT
2081
SLTQI
2086
KEKVL
2091
EHSHR
2096
PIQLR
2101
KGDFY
2106
SYLSL
2111
SSHDS
2116
DCGEV
2121
TNYIE
2126
EKSST
2131
PLPLD
2136
TTDSG
2141
LDDKE
2146
DIECF
2151
FEACV
2156
EGDSD
2161
GEEPC
2166
FSSAP
2171
PNESA
2176
VPSEA
2181
AMPLQ
2186
ATACS
2191
SEFSD
2196
SSLSA
2201
DDADT
2206
VALSS
2211
PSSQE
2216
RAEVG
2221
KEVNG
2226
LPQTS
2231
SGCAE
2236
NLEFT
2241
PSKLD
2246
SEKES
2251
SGKPG
2256
ESGMP
2261
EEHNA
2266
ASAKS
2271
KVQDL
2276
SLKAN
2281
QPTDK
2286
AALHP
2291
SPKTL
2296
TCEEN
2301
LLNLH
2306
EKRHR
2311
NMHR
2316
Mutation Information
DNA mutation:
c.G3097T
Peptide Range:
1021 ~ 1045
Mut AA position:
1033 (13 in Wild Type peptide)
Alignment
Wild Type:
"EALKKGGVLLPNDLLEKVDSINEKW
||||||||||||.||||||||||||
Mutant:
EALKKGGVLLPNYLLEKVDSINEKW"
N Engl J Med, 2016
T-Cell Transfer Therapy Targeting Mutant KRAS in CancerGene Name (from Reference) AKAP6
Checkpoint
Blockade
None
ACT
None
Vaccination
None
Curative
Effect
None
minimal_peptide
None
Antigen
Type
TMG RNA
T-cell
Source
TILs
APC
Type
DCs
Assay
IFNg ELISPOT assay