Immunogenicity 15357

summary
Sample ID
4095
Response
Negative
Tumor Type
Colorectal cancer
Gene Symbol
ANKRD18B (FPKM: 0.19)
Transcript ID
ENST00000290943
HLA INFO
B*44:03
TCR INFO

No TCR info found!

T cell Tumor cell B*44:03
sequence
Full length protein sequence (1011 aa)
MRKLL
1
SFGRR
6
LGQAL
11
LSSMD
16
QEYAG
21
RGYHI
26
RDWEL
31
RKIHR
36
AAIKG
41
DAAEV
46
EHCLT
51
RRFRD
56
LDVRD
61
RKDRT
66
VLHLA
71
CAHGR
76
VQVVT
81
LLLDR
86
KCQIN
91
ICDRL
96
NRTPL
101
MKAVH
106
CQEEA
111
CAIIL
116
LKRGA
121
NPNIK
126
DIYGN
131
TALHY
136
AVYNE
141
GTSLA
146
ERLLS
151
HHANI
156
EALNK
161
EGNTP
166
LLFAI
171
NSRRQ
176
HMVEF
181
LLKNQ
186
ANIHA
191
VDNFK
196
RTALI
201
LAVQH
206
NLSSI
211
VTLLL
216
QQNIH
221
ISSQD
226
MFGQT
231
AEDYA
236
FCCDL
241
RSIQQ
246
QILEH
251
KNKML
256
KNHLR
261
NDNQE
266
TAAMK
271
PENLK
276
KRKKR
281
KKLKK
286
RKEGA
291
KAEHN
296
LKVAS
301
EEKQE
306
RLERS
311
ENKQP
316
QDSQS
321
YGKKK
326
DEMFG
331
NFMLK
336
RDIAM
341
LKEEL
346
YAIKN
351
DSLRK
356
EKKYI
361
QEIKS
366
ITEIN
371
ANFEK
376
SVRLN
381
EEMIT
386
KKVAQ
391
YSQQL
396
NDLKA
401
ENARL
406
NSKLE
411
KEKHN
416
KERLE
421
AEVES
426
LHSNL
431
ATAIN
436
EYNEI
441
LERKD
446
LELVL
451
WRADD
456
VSRHE
461
TMGSN
466
ISQLT
471
DKNEL
476
LTEQV
481
HKARV
486
KFNTL
491
KGKLR
496
ETRDA
501
LREKT
506
LALES
511
VQLDL
516
KQAQH
521
RIKEM
526
KQMHP
531
NGEAK
536
ESQSI
541
GKQNS
546
SEERI
551
RQREL
556
ENLLL
561
ERQLE
566
DARKE
571
GDNKE
576
IVINI
581
HRDCL
586
ENGKE
591
DLLEE
596
RNKEL
601
MNEYN
606
YLKEK
611
LLQYE
616
KEKAE
621
REVIV
626
REFQE
631
ELVDH
636
LKKFS
641
MSESP
646
LEGTS
651
HCHIN
656
LDETW
661
TSKKK
666
LFQVE
671
IQPEE
676
KHEEF
681
RKVFE
686
LISLL
691
NYTAD
696
QIRKK
701
NRELE
706
EEATG
711
YKKCL
716
EMTIN
721
MLNAF
726
ANEDF
731
SCHGD
736
LNTDQ
741
LKMDI
746
LFKKL
751
KQKFD
756
DLMAE
761
KEAVS
766
SKCVN
771
LAKDN
776
EVLHQ
781
ELLSM
786
GKVQE
791
KCEKL
796
EKDKK
801
MLEEK
806
VLNLK
811
THMEK
816
DMVEL
821
GKVQE
826
YKSEL
831
DERAM
836
QAIEK
841
LEEIH
846
LQKQA
851
EYEKQ
856
LEQLN
861
KDNTA
866
SLKKK
871
ELTLK
876
DVECK
881
FSKMK
886
TAYED
891
VTTEL
896
EEYKE
901
AFAVA
906
LKANS
911
SMSEK
916
ITKSD
921
KKIAV
926
ISTKL
931
FMEKE
936
RMEYF
941
LSTLP
946
MRPDP
951
ELPCV
956
ENLNS
961
IELNR
966
KYIPK
971
MAIRI
976
PTSNP
981
QTSNN
986
CKNSL
991
TELLL
996
RWALA
1001
PIYFL
1006
L
1011
Mutation Information
DNA mutation:
c.C1190T
Peptide Range:
385 ~ 409
Mut AA position:
397 (13 in Wild Type peptide)
Alignment
Wild Type:
"NEEMITKKVAQYSQQLNDLKAENAR
||||||||||||.||||||||||||
Mutant:
NEEMITKKVAQYLQQLNDLKAENAR"
reference

N Engl J Med, 2016

T-Cell Transfer Therapy Targeting Mutant KRAS in Cancer

Gene Name (from Reference) ANKRD18B

clinic trial
Checkpoint Blockade

None

ACT

None

Vaccination

None

Curative Effect

None

experiment
minimal_peptide

None

Antigen Type

TMG RNA

T-cell Source

TILs

APC Type

DCs

Assay

IFNg ELISPOT assay