Immunogenicity 15363

summary
Sample ID
4095
Response
Negative
Tumor Type
Colorectal cancer
Gene Symbol
AGAP3 (FPKM: 22.56)
Transcript ID
ENST00000397238
HLA INFO
B*44:03
TCR INFO

No TCR info found!

T cell Tumor cell B*44:03
sequence
Full length protein sequence (911 aa)
MNFQA
1
GGGQS
6
PQQQQ
11
SLAAP
16
GGGGA
21
AAQQL
26
VCGGQ
31
FGGAG
36
PGAGG
41
GGGPS
46
QQLAG
51
GPPQQ
56
FALSN
61
SAAIR
66
AEIQR
71
FESVH
76
PNIYA
81
IYDLI
86
ERIED
91
LALQN
96
QIREH
101
VISIE
106
DSFVN
111
SQEWT
116
LSRSV
121
PELKV
126
GIVGN
131
LSSGK
136
SALVH
141
RYLTG
146
TYVQE
151
ESPEG
156
GRFKK
161
EIVVD
166
GQSYL
171
LLIRD
176
EGGPP
181
ELQFA
186
AWVDA
191
VVFVF
196
SLEDE
201
ISFQT
206
VYNYF
211
LRLCS
216
FRNAS
221
EVPMV
226
LVGTQ
231
DAISA
236
ANPRV
241
IDDSR
246
ARKLS
251
TDLKR
256
CTYYE
261
TCATY
266
GLNVE
271
RVFQD
276
VAQKV
281
VALRK
286
KQQLA
291
IGPCK
296
SLPNS
301
PSHSA
306
VSAAS
311
IPAVH
316
INQAT
321
NGGGS
326
AFSDY
331
SSSVP
336
STPSI
341
SQREL
346
RIETI
351
AASST
356
PTPIR
361
KQSKR
366
RSNIF
371
TSRKG
376
ADLDR
381
EKKAA
386
ECKVD
391
SIGSG
396
RAIPI
401
KQGIL
406
LKRSG
411
KSLNK
416
EWKKK
421
YVTLC
426
DNGLL
431
TYHPS
436
LHDYM
441
QNIHG
446
KEIDL
451
LRTTV
456
KVPGK
461
RLPRA
466
TPATA
471
PGTSP
476
RANGL
481
SVERS
486
NTQLG
491
GGTGA
496
PHSAS
501
SASLH
506
SERPL
511
SSSAW
516
AGPRP
521
EGLHQ
526
RSCSV
531
SSADQ
536
WSEAT
541
TSLPP
546
GMQHP
551
ASGPA
556
EVLSS
561
SPKLD
566
PPPSP
571
HSNRK
576
KHRRK
581
KSTGT
586
PRPDG
591
PSSAT
596
EEAEE
601
SFEFV
606
VVSLT
611
GQTWH
616
FEAST
621
AEERE
626
LWVQS
631
VQAQI
636
LASLQ
641
GCRSA
646
KDKTR
651
LGNQN
656
AALAV
661
QAVRT
666
VRGNS
671
FCIDC
676
DAPNP
681
DWASL
686
NLGAL
691
MCIEC
696
SGIHR
701
HLGAH
706
LSRVR
711
SLDLD
716
DWPPE
721
LLAVM
726
TAMGN
731
ALANS
736
VWEGA
741
LGGYS
746
KPGPD
751
ACREE
756
KERWI
761
RAKYE
766
QKLFL
771
APLPS
776
SDVPL
781
GQQLL
786
RAVVE
791
DDLRL
796
LVMLL
801
AHGSK
806
EEVNE
811
TYGDG
816
DGRTA
821
LHLSS
826
AMANV
831
VFTQL
836
LIWYG
841
VDVRS
846
RDARG
851
LTPLA
856
YARRA
861
GSQEC
866
ADILI
871
QHGCP
876
GEGCG
881
LAPTP
886
NREPA
891
NGTNP
896
SAELH
901
RSPSL
906
L
911
Mutation Information
DNA mutation:
c.A1727C
Peptide Range:
564 ~ 588
Mut AA position:
576 (13 in Wild Type peptide)
Alignment
Wild Type:
"SSSPKLDPPPSPHSNRKKHRRKKST
||||||||||||.||||||||||||
Mutant:
SSSPKLDPPPSPPSNRKKHRRKKST"
reference

N Engl J Med, 2016

T-Cell Transfer Therapy Targeting Mutant KRAS in Cancer

Gene Name (from Reference) AGAP3

clinic trial
Checkpoint Blockade

None

ACT

None

Vaccination

None

Curative Effect

None

experiment
minimal_peptide

None

Antigen Type

TMG RNA

T-cell Source

TILs

APC Type

DCs

Assay

IFNg ELISPOT assay