Immunogenicity 15457
Sample ID
4095
Response
Negative
Tumor Type
Colorectal cancer
Gene Symbol
NPC1L1 (FPKM: 0.03)
Transcript ID
NM_001101648
HLA INFO
A*02:01
TCR INFO
No TCR info found!
Full length protein sequence (1332 aa)
MAEAG
1
LRGWL
6
LWALL
11
LRLAQ
16
SEPYT
21
TIHQP
26
GYCAF
31
YDECG
36
KNPEL
41
SGSLM
46
TLSNV
51
SCLSN
56
TPARK
61
ITGDH
66
LILLQ
71
KICPR
76
LYTGP
81
NTQAC
86
CSAKQ
91
LVSLE
96
ASLSI
101
TKALL
106
TRCPA
111
CSDNF
116
VNLHC
121
HNTCS
126
PNQSL
131
FINVT
136
RVAQL
141
GAGQL
146
PAVVA
151
YEAFY
156
QHSFA
161
EQSYD
166
SCSRV
171
RVPAA
176
ATLAV
181
GTMCG
186
VYGSA
191
LCNAQ
196
RWLNF
201
QGDTG
206
NGLAP
211
LDITF
216
HLLEP
221
GQAVG
226
SGIQP
231
LNEGV
236
ARCNE
241
SQGDD
246
VATCS
251
CQDCA
256
ASCPA
261
IARPQ
266
ALDST
271
FYLGQ
276
MPGSL
281
VLIII
286
LCSVF
291
AVVTI
296
LLVGF
301
RVAPA
306
RDKSK
311
MVDPK
316
KGTSL
321
SDKLS
326
FSTHT
331
LLGQF
336
FQGWG
341
TWVAS
346
WPLTI
351
LVLSV
356
IPVVA
361
LAAGL
366
VFTEL
371
TTDPV
376
ELWSA
381
PNSQA
386
RSEKA
391
FHDQH
396
FGPFF
401
RTNQV
406
ILTAP
411
NRSSY
416
RYDSL
421
LLGPK
426
NFSGI
431
LDLDL
436
LLELL
441
ELQER
446
LRHLQ
451
VWSPE
456
AQRNI
461
SLQDI
466
CYAPL
471
NPDNT
476
SLYDC
481
CINSL
486
LQYFQ
491
NNRTL
496
LLLTA
501
NQTLM
506
GQTSQ
511
VDWKD
516
HFLYC
521
ANAPL
526
TFKDG
531
TALAL
536
SCMAD
541
YGAPV
546
FPFLA
551
IGGYK
556
GKDYS
561
EAEAL
566
IMTFS
571
LNNYP
576
AGDPR
581
LAQAK
586
LWEEA
591
FLEEM
596
RAFQR
601
RMAGM
606
FQVTF
611
MAERS
616
LEDEI
621
NRTTA
626
EDLPI
631
FATSY
636
IVIFL
641
YISLA
646
LGSYS
651
SWSRV
656
MVDSK
661
ATLGL
666
GGVAV
671
VLGAV
676
MAAMG
681
FFSYL
686
GIRSS
691
LVILQ
696
VVPFL
701
VLSVG
706
ADNIF
711
IFVLE
716
YQRLP
721
RRPGE
726
PREVH
731
IGRAL
736
GRVAP
741
SMLLC
746
SLSEA
751
ICFFL
756
GALTP
761
MPAVR
766
TFALT
771
SGLAV
776
ILDFL
781
LQMSA
786
FVALL
791
SLDSK
796
RQEAS
801
RLDVC
806
CCVKP
811
QELPP
816
PGQGE
821
GLLLG
826
FFQKA
831
YAPFL
836
LHWIT
841
RGVVL
846
LLFLA
851
LFGVS
856
LYSMC
861
HISVG
866
LDQEL
871
ALPKD
876
SYLLD
881
YFLFL
886
NRYFE
891
VGAPV
896
YFVTT
901
LGYNF
906
SSEAG
911
MNAIC
916
SSAGC
921
NNFSF
926
TQKIQ
931
YATEF
936
PEQSY
941
LAIPA
946
SSWVD
951
DFIDW
956
LTPSS
961
CCRLY
966
ISGPN
971
KDKFC
976
PSTVN
981
SLNCL
986
KNCMS
991
ITMGS
996
VRPSV
1001
EQFHK
1006
YLPWF
1011
LNDRP
1016
NIKCP
1021
KGGLA
1026
AYSTS
1031
VNLTS
1036
DGQVL
1041
ASRFM
1046
AYHKP
1051
LKNSQ
1056
DYTEA
1061
LRAAR
1066
ELAAN
1071
ITADL
1076
RKVPG
1081
TDPAF
1086
EVFPY
1091
TITNV
1096
FYEQY
1101
LTILP
1106
EGLFM
1111
LSLCL
1116
VPTFA
1121
VSCLL
1126
LGLDL
1131
RSGLL
1136
NLLSI
1141
VMILV
1146
DTVGF
1151
MALWG
1156
ISYNA
1161
VSLIN
1166
LVSAV
1171
GMSVE
1176
FVSHI
1181
TRSFA
1186
ISTKP
1191
TWLER
1196
AKEAT
1201
ISMGS
1206
AVFAG
1211
VAMTN
1216
LPGIL
1221
VLGLA
1226
KAQLI
1231
QIFFF
1236
RLNLL
1241
ITLLG
1246
LLHGL
1251
VFLPV
1256
ILSYV
1261
GPDVN
1266
PALAL
1271
EQKRA
1276
EEAVA
1281
AVMVA
1286
SCPNH
1291
PSRVS
1296
TADNI
1301
YVNHS
1306
FEGSI
1311
KGAGA
1316
ISNFL
1321
PNNGR
1326
QF
1331
Mutation Information
DNA mutation:
c.C724T
Peptide Range:
230 ~ 254
Mut AA position:
242 (13 in Wild Type peptide)
Alignment
Wild Type:
"GSGIQPLNEGVARCNESQGDDVATC
||||||||||||.||||||||||||
Mutant:
GSGIQPLNEGVACCNESQGDDVATC"
N Engl J Med, 2016
T-Cell Transfer Therapy Targeting Mutant KRAS in CancerGene Name (from Reference) NPC1L1
Checkpoint
Blockade
None
ACT
None
Vaccination
None
Curative
Effect
None
minimal_peptide
None
Antigen
Type
TMG RNA
T-cell
Source
TILs
APC
Type
DCs
Assay
IFNg ELISPOT assay