Immunogenicity 15608

summary
Sample ID
4095
Response
Negative
Tumor Type
Colorectal cancer
Gene Symbol
WWC1 (FPKM: 7.46)
Transcript ID
NM_001161661
HLA INFO
B*44:03
TCR INFO

No TCR info found!

T cell Tumor cell B*44:03
sequence
Full length protein sequence (1119 aa)
MPRPE
1
LPLPE
6
GWEEA
11
RDFDG
16
KVYYI
21
DHTNR
26
TTSWI
31
DPRDR
36
YTKPL
41
TFADC
46
ISDEL
51
PLGWE
56
EAYDP
61
QVGDY
66
FIDHN
71
TKTTQ
76
IEDPR
81
VQWRR
86
EQEHM
91
LKDYL
96
VVAQE
101
ALSAQ
106
KEIYQ
111
VKQQR
116
LELAQ
121
QEYQQ
126
LHAVW
131
EHKLG
136
SQVSL
141
VSGSS
146
SSSKY
151
DPEIL
156
KAEIA
161
TAKSR
166
VNKLK
171
REMVH
176
LQHEL
181
QFKER
186
GFQTL
191
KKIDK
196
KMSDA
201
QGSYK
206
LDEAQ
211
AVLRE
216
TKAIK
221
KAITC
226
GEKEK
231
QDLIK
236
SLAML
241
KDGFR
246
TDRGS
251
HSDLW
256
SSSSS
261
LESSS
266
FPLPK
271
QYLDV
276
SSQTD
281
ISGSF
286
GINSN
291
NQLAE
296
KVRLR
301
LRYEE
306
AKRRI
311
ANLKI
316
QLAKL
321
DSEAW
326
PGVLD
331
SERDR
336
LILIN
341
EKEEL
346
LKEMR
351
FISPR
356
KWTQG
361
EVEQL
366
EMARK
371
RLEKD
376
LQAAR
381
DTQSK
386
ALTER
391
LKLNS
396
KRNQL
401
VRELE
406
EATRQ
411
VATLH
416
SQLKS
421
LSSSM
426
QSLSS
431
GSSPG
436
SLTSS
441
RGSLV
446
ASSLD
451
SSTSA
456
SFTDL
461
YYDPF
466
EQLDS
471
ELQSK
476
VEFLL
481
LEGAT
486
GFRPS
491
GCITT
496
IHEDE
501
VAKTQ
506
KAEGG
511
GRLQA
516
LRSLS
521
GTPKS
526
MTSLS
531
PRSSL
536
SSPSP
541
PCSPL
546
MADPL
551
LAGDA
556
FLNSL
561
EFEDP
566
ELSAT
571
LCELS
576
LGNSA
581
QERYR
586
LEEPG
591
TEGKQ
596
LGQAV
601
NTAQG
606
CGLKV
611
ACVSA
616
AVSDE
621
SVAGD
626
SGVYE
631
ASVQR
636
LGASE
641
AAAFD
646
SDESE
651
AVGAT
656
RIQIA
661
LKYDE
666
KNKQF
671
AILII
676
QLSNL
681
SALLQ
686
QQDQK
691
VNIRV
696
AVLPC
701
SESTT
706
CLFRT
711
RPLDA
716
SDTLV
721
FNEVF
726
WVSMS
731
YPALH
736
QKTLR
741
VDVCT
746
TDRSH
751
LEECL
756
GGAQI
761
SLAEV
766
CRSGE
771
RSTRW
776
YNLLS
781
YKYLK
786
KQSRE
791
LKPVG
796
VMAPA
801
SGPAS
806
TDAVS
811
ALLEQ
816
TAVEL
821
EKRQE
826
GRSST
831
QTLED
836
SWRYE
841
ETSEN
846
EAVAE
851
EEEEE
856
VEEEE
861
GEEDV
866
FTEKA
871
SPDMD
876
GYPAL
881
KVDKE
886
TNTET
891
PAPSP
896
TVVRP
901
KDRRV
906
GTPSQ
911
GPFLR
916
GSTII
921
RSKTF
926
SPGPQ
931
SQYVC
936
RLNRS
941
DSDSS
946
TLSKK
951
PPFVR
956
NSLER
961
RSVRM
966
KRPSP
971
PPQPS
976
SVKSL
981
RSERL
986
IRTSL
991
DLELD
996
LQATR
1001
TWHSQ
1006
LTQEI
1011
SVLKE
1016
LKEQL
1021
EQAKS
1026
HGEKE
1031
LPQWL
1036
REDER
1041
FRLLL
1046
RMLEK
1051
RQMDR
1056
AEHKG
1061
ELQTD
1066
KMMRA
1071
AAKDV
1076
HRLRG
1081
QSCKE
1086
PPEVQ
1091
SFREK
1096
MAFFT
1101
RPRMN
1106
IPALS
1111
ADDV
1116
Mutation Information
DNA mutation:
c.G2013T
Peptide Range:
659 ~ 683
Mut AA position:
671 (13 in Wild Type peptide)
Alignment
Wild Type:
"ATRIQIALKYDEKNKQFAILIIQLS
||||||||||||.||||||||||||
Mutant:
ATRIQIALKYDENNKQFAILIIQLS"
reference

N Engl J Med, 2016

T-Cell Transfer Therapy Targeting Mutant KRAS in Cancer

Gene Name (from Reference) WWC1

clinic trial
Checkpoint Blockade

None

ACT

None

Vaccination

None

Curative Effect

None

experiment
minimal_peptide

None

Antigen Type

TMG RNA

T-cell Source

TILs

APC Type

DCs

Assay

IFNg ELISPOT assay