Immunogenicity 15697

summary
Sample ID
patient2
Response
Positive
Tumor Type
Melanoma
Gene Symbol
ITGA9
Transcript ID
None
HLA INFO
A*01:01
TCR INFO

No TCR info found!

T cell Tumor cell A*01:01
sequence
Full length protein sequence (1035 aa)
MGGPA
1
APRGA
6
GRLRA
11
LLLAL
16
VVAGI
21
PAGAY
26
NLDPQ
31
RPVHF
36
QGPAD
41
SFFGY
46
AVLEH
51
FHDNT
56
RWVLV
61
GAPKA
66
DSKYS
71
PSVKS
76
PGAVF
81
KCRVH
86
TNPDR
91
RCTEL
96
DMARG
101
KNRGT
106
SCGKT
111
CREDR
116
DDEWM
121
GVSLA
126
RQPKA
131
DGRVL
136
ACAHR
141
WKNIY
146
YEADH
151
ILPHG
156
FCYII
161
PSNLQ
166
AKGRT
171
LIPCY
176
EEYKK
181
KYGEE
186
HGSCQ
191
AGIAG
196
FFTEE
201
LVVMG
206
APGSF
211
YWAGT
216
IKVLN
221
LTDNT
226
YLKLN
231
DEVIM
236
NRRYT
241
YLGYA
246
VTAGH
251
FSHPS
256
TIDVV
261
GGAPQ
266
DKGIG
271
KVYIF
276
RADRR
281
SGTLI
286
KIFQA
291
SGKKM
296
GSYFG
301
SSLCA
306
VDLNG
311
DGLSD
316
LLVGA
321
PMFSE
326
IRDEG
331
QVTVY
336
INRGN
341
GALEE
346
QLALT
351
GDGAY
356
NAHFG
361
ESIAS
366
LDDLD
371
NDGFP
376
DVAIG
381
APKED
386
DFAGA
391
VYIYH
396
GDAGG
401
IVPQY
406
SMKLS
411
GQKIN
416
PVLRM
421
FGQSI
426
SGGID
431
MDGNG
436
YPDVT
441
VGAFM
446
SDSVV
451
LLRAR
456
PVITV
461
DVSIF
466
LPGSI
471
NITAP
476
QCHDG
481
QQPVN
486
CLNVT
491
TCFSF
496
HGKHV
501
PGEIG
506
LNYVL
511
MADVA
516
KKEKG
521
QMPRV
526
YFVLL
531
GETMG
536
QVTEK
541
LQLTY
546
MEETC
551
RHYVA
556
HVKRR
561
VQDVI
566
SPIVF
571
EAAYS
576
LSEHV
581
TGEEE
586
RELPP
591
LTPVL
596
RWKKG
601
QKIAQ
606
KNQTV
611
FERNC
616
RSEDC
621
AADLQ
626
LQGKL
631
LLSSM
636
DEKTL
641
YLALG
646
AVKNI
651
SLNIS
656
ISNLG
661
DDAYD
666
ANVSF
671
NVSRE
676
LFFIN
681
MWQKE
686
EMGIS
691
CELLE
696
SDFLK
701
CSVGF
706
PFMRS
711
KSKYE
716
FSVIF
721
DTSHL
726
SGEEE
731
VLSFI
736
VTAQS
741
GNTER
746
SESLH
751
DNTLV
756
LMVPL
761
MHEVD
766
TSITG
771
IMSPT
776
SFVYG
781
ESVDA
786
ANFIQ
791
LDDLE
796
CHFQP
801
INITL
806
QVYNT
811
GPSTL
816
PGSSV
821
SISFP
826
NRLSS
831
GGAEM
836
FHVQE
841
MVVGQ
846
EKGNC
851
SFQKN
856
PTPCI
861
IPQEQ
866
ENIFH
871
TIFAF
876
FTKSG
881
RKVLD
886
CEKPG
891
ISCLT
896
AHCNF
901
SALAK
906
EESRT
911
IDIYM
916
LLNTE
921
ILKKD
926
SSSVI
931
QFMSR
936
AKVKV
941
DPALR
946
VVEIA
951
HGNPE
956
EVTVV
961
FEALH
966
NLEPR
971
GYVVG
976
WIIAI
981
SLLVG
986
ILIFL
991
LLAVL
996
LWKMG
1001
FFRRR
1006
YKEII
1011
EAEKN
1016
RKENE
1021
DSWDW
1026
VQKNQ
1031
Mutation Information
DNA mutation:
None
Peptide Range:
542 ~ 550
Mut AA position:
548 (7 in Wild Type peptide)
Alignment
Wild Type:
"VTEKLQLTY
||||||.||
Mutant:
VTEKLQPTY"
reference

Nature, 2017

An immunogenic personal neoantigen vaccine for patients with melanoma

Gene Name (from Reference) ITGA9

clinic trial
Checkpoint Blockade

pembrolizumab

ACT

N

Vaccination

Y

Curative Effect

tumour regression

experiment
minimal_peptide

Y

Antigen Type

peptide

T-cell Source

PBMCs

APC Type

APCs

Assay

None