Immunogenicity 15703
Sample ID
3713
Response
Positive
Tumor Type
Melanoma
Gene Symbol
HELZ2
Transcript ID
None
HLA INFO
A*29:02
TCR INFO
TRBVBV27-1
CDR3BASSLNSGHTQYF
Full length protein sequence (2677 aa)
MAVWE
1
AEQLG
6
GLQRG
11
DLLTP
16
PAPDG
21
DGRTA
26
PLGQP
31
PGAQL
36
YCPAC
41
LVTCH
46
SQEAF
51
ENHCA
56
SSEHA
61
QMVAF
66
DQALP
71
WEHRS
76
PPPGL
81
SKFEL
86
CPKPD
91
LCEYG
96
DACTK
101
AHSAQ
106
ELQEW
111
VRRTQ
116
AVELR
121
GQAAW
126
QDGLV
131
PYQER
136
LLAEY
141
QRSSS
146
EVLVL
151
AETLD
156
GVRVT
161
CNQPL
166
MYQAQ
171
ERKTQ
176
YSWTF
181
AVHSE
186
EPLLH
191
VALLK
196
QEPGA
201
DFSLV
206
APGLP
211
PGRLY
216
ARGER
221
FRVPS
226
STADF
231
QVGVR
236
VQAAS
241
FGTFE
246
QWVVF
251
DFGRR
256
PVLLQ
261
KLGLQ
266
LGQGR
271
RPGPC
276
RNLAL
281
GHPEE
286
MERWH
291
TGNRH
296
VVPGV
301
ERTAE
306
QTALM
311
AKYKG
316
PALAL
321
EFNRS
326
SVASG
331
PISPT
336
NYRQR
341
MHQFL
346
YEEEA
351
AQQQL
356
VAKLT
361
LRGQV
366
FLKTA
371
LQTPA
376
LNMLF
381
APPGA
386
LYAEV
391
PVPSS
396
LMPDT
401
DQGFL
406
LGRAV
411
STALV
416
APVPA
421
PDNTV
426
FEVRL
431
ERRAS
436
SEQAL
441
WLLLP
446
ARCCL
451
ALGLQ
456
PEARL
461
VLEVQ
466
FQIDP
471
MTFRL
476
WHQAV
481
DTLPE
486
EQLVV
491
PDLPT
496
CALPR
501
PWSVP
506
PLRRG
511
NRKQE
516
LAVAL
521
IAGWG
526
PGDGR
531
RVPPL
536
LIYGP
541
FGTGK
546
TYTLA
551
MASLE
556
VIRRP
561
ETKVL
566
ICTHT
571
NSAAD
576
IYIRE
581
YFHSH
586
VSGGH
591
PEATP
596
LRVMY
601
TDRPL
606
SQTDP
611
VTLQY
616
CCLTD
621
DRQAF
626
RPPTR
631
AELAR
636
HRVVV
641
TTTSQ
646
ARELR
651
VPVGF
656
FSHIL
661
IDEAA
666
QMLEC
671
EALTP
676
LAYAS
681
HGTRL
686
VLAGD
691
HMQVT
696
PRLFS
701
VARAR
706
AAEHT
711
LLHRL
716
FLCYQ
721
QETHE
726
VARQS
731
RLVFH
736
ENYRC
741
TDAIV
746
SFISR
751
HFYVA
756
KGNPI
761
HARGK
766
VPPHP
771
RHYPL
776
MFCHV
781
AGSPD
786
RDMSM
791
ASWLN
796
LAEIA
801
QVVEK
806
VQEAY
811
NTWPS
816
CWGGR
821
EQRCI
826
CVVSH
831
GAQVS
836
ALRQE
841
LRRRD
846
LGQVS
851
VGSFE
856
ILPGR
861
QFRVV
866
VLSTV
871
HTCQS
876
LLSPG
881
ALAPE
886
FFTDA
891
RVLNT
896
VLTRA
901
QSQLV
906
VVGDA
911
VALCS
916
FGACG
921
KLWES
926
FIREC
931
VERHS
936
VCPEG
941
LSMEQ
946
VEQGV
951
AQRRR
956
WPPRG
961
TQAGA
966
AGNWE
971
AAPEP
976
VGDLA
981
EEQAA
986
VVTAM
991
VKAEP
996
GDEAL
1001
SPASR
1006
DITAT
1011
TAQTE
1016
AAAAP
1021
AGDAV
1026
KEDVV
1031
PGACA
1036
AGAAA
1041
AAGVE
1046
STEAE
1051
DAEAD
1056
FWPWD
1061
GELNA
1066
DDAIL
1071
RELLD
1076
ESQKV
1081
MVTVG
1086
EDGLL
1091
DTVAR
1096
PESLQ
1101
QARLY
1106
ENLPP
1111
AALRK
1116
LLHAE
1121
PERYR
1126
HCSFV
1131
PETFE
1136
RASAI
1141
PLDDA
1146
SSGPI
1151
QVRGR
1156
LDCGM
1161
AFAGD
1166
EVLVQ
1171
LLSGD
1176
KAPEG
1181
RLRGR
1186
VLGVL
1191
KRKRH
1196
ELAFV
1201
CRMDT
1206
WDPRI
1211
MVPIN
1216
GSVTK
1221
IFVAE
1226
LKDPS
1231
QVPIY
1236
SLRKG
1241
RLQRV
1246
GLERL
1251
TAEAR
1256
HSRLF
1261
WVQIV
1266
LWRQG
1271
FYYPL
1276
GIVRE
1281
VLPEA
1286
STWEQ
1291
GLRIL
1296
GLEYS
1301
LRVPP
1306
SDQAT
1311
ITKVL
1316
QKYHT
1321
ELGRV
1326
AGRRE
1331
DCRAF
1336
LTFTV
1341
DPQGA
1346
CNLDD
1351
ALSVR
1356
DLGPR
1361
CEVAV
1366
HITDV
1371
ASFVP
1376
RDGVL
1381
DVEAR
1386
RQGAA
1391
FYAPG
1396
REPVP
1401
MLPAS
1406
LCQDV
1411
LSLLP
1416
GRDRL
1421
AISLF
1426
LTMEK
1431
ASGQL
1436
KSLRF
1441
APSVV
1446
QSDRQ
1451
LSYEE
1456
AEEVI
1461
RQHPG
1466
AGREL
1471
PARLD
1476
SVDAC
1481
VVAAC
1486
YFSRL
1491
LRRHR
1496
LRSDC
1501
FYEQP
1506
DEDGT
1511
LGFRA
1516
AHIMV
1521
KEYMI
1526
QFNRL
1531
VAEFL
1536
VGSEC
1541
TRTVT
1546
PLRWQ
1551
PAPRS
1556
QQLKA
1561
LCEKH
1566
GDRVP
1571
LSLHL
1576
GHHLH
1581
GGGGS
1586
PPDTR
1591
LHLLA
1596
SLWKQ
1601
VQFAA
1606
RTQDY
1611
EQMVD
1616
LVTTD
1621
DMHPF
1626
LAPAG
1631
RDLRK
1636
ALERS
1641
AFGRC
1646
ARGHQ
1651
QQGGH
1656
YSLQV
1661
DWYTW
1666
ATSPI
1671
RRYLD
1676
VVLQR
1681
QILLA
1686
LGHGG
1691
SAYSA
1696
RDIDG
1701
LCQAF
1706
SLQHA
1711
LAQSY
1716
QRRAR
1721
SLHLA
1726
VQLKA
1731
QPLDK
1736
LGFVV
1741
DVEAG
1746
SRCFR
1751
LLFPS
1756
NRETL
1761
PDPCP
1766
VPYGS
1771
LQLAE
1776
HPHAL
1781
AGRPG
1786
LRLLW
1791
RRRVY
1796
SAQGS
1801
SPPLP
1806
LPGTV
1811
PDPHT
1816
LAVET
1821
ALWKQ
1826
LLELV
1831
ELQRW
1836
PEAAA
1841
LIQEK
1846
GEASQ
1851
RRELV
1856
QVQRS
1861
HCGHF
1866
LEVAR
1871
ELGSG
1876
DTLQV
1881
QLGTS
1886
LQHGF
1891
LVPSP
1896
QLWTV
1901
APGFS
1906
LCLEH
1911
VERPG
1916
DCFSG
1921
RVYRA
1926
PRDRY
1931
RDVDE
1936
YACVW
1941
EPFCA
1946
LESAT
1951
GAVAE
1956
NDSVT
1961
LQHLS
1966
VSWEA
1971
SRTPQ
1976
GQLQG
1981
AFRLE
1986
AAFLE
1991
ENCAD
1996
INFSC
2001
CYLCI
2006
RLEGL
2011
PAPTA
2016
SPRPG
2021
PSSLG
2026
PGLNV
2031
DPGTY
2036
TWVAH
2041
GQTQD
2046
WDQER
2051
RADRQ
2056
EAPRR
2061
VHLFV
2066
HHMGM
2071
EKVPE
2076
EVLRP
2081
GTLFT
2086
VELLP
2091
KQLPD
2096
LRKEE
2101
AVRGL
2106
EEASP
2111
LVTSI
2116
ALGRP
2121
VPQPL
2126
CRGRS
2131
APPLQ
2136
LPLWP
2141
PAPPC
2146
MSAQG
2151
GCPLS
2156
VIPSR
2161
FLERQ
2166
TYNIP
2171
GGRHK
2176
LNPSQ
2181
NVAVR
2186
EALEK
2191
PFTVI
2196
QGPPG
2201
TGKTI
2206
VGLHI
2211
VFWFH
2216
KSNQE
2221
QVQPG
2226
GPPRG
2231
EKRLG
2236
GPCIL
2241
YCGPS
2246
NKSVD
2251
VLAGL
2256
LLRRM
2261
ELKPL
2266
RVYSE
2271
QAEAS
2276
EFPVP
2281
RVGSR
2286
KLLRK
2291
SPREG
2296
RPNQS
2301
LRSIT
2306
LHHRI
2311
RQAPN
2316
PYSSE
2321
IKAFD
2326
TRLQR
2331
GELFS
2336
REDLV
2341
WYKKV
2346
LWEAR
2351
KFELD
2356
RHEVI
2361
LCTCS
2366
CAASA
2371
SLKIL
2376
DVRQI
2381
LVDEA
2386
GMATE
2391
PETLI
2396
PLVQF
2401
PQAEK
2406
VVLLG
2411
DHKQL
2416
RPVVK
2421
NERLQ
2426
NLGLD
2431
RSLFE
2436
RYHED
2441
AHMLD
2446
TQYRM
2451
HEGIC
2456
AFPSV
2461
AFYKS
2466
KLKTW
2471
QGLRR
2476
PPSVL
2481
GHAGK
2486
ESCPV
2491
IFGHV
2496
QGHER
2501
SLLVS
2506
TDEGN
2511
ENSKA
2516
NLEEV
2521
AEVVR
2526
ITKQL
2531
TLGRT
2536
VEPQD
2541
IAVLT
2546
PYNAQ
2551
ASEIS
2556
KALRR
2561
EGIAG
2566
VAVSS
2571
ITKSQ
2576
GSEWR
2581
YVLVS
2586
TVRTC
2591
AKSDL
2596
DQRPT
2601
KSWLK
2606
KFLGF
2611
VVDPN
2616
QVNVA
2621
VTRAQ
2626
EGLCL
2631
IGDHL
2636
LLRCC
2641
PLWRS
2646
LLDFC
2651
EAQQT
2656
LVPAG
2661
QVRVC
2666
RRPTM
2671
PS
2676
Mutation Information
DNA mutation:
None
Peptide Range:
612 ~ 620
Mut AA position:
None (3 in Wild Type peptide)
Alignment
Wild Type:
"QTDPVTLQY
||.||||||
Mutant:
QTNPVTLQY"
Cancer Immunol Res, 2016
Durable Complete Response from Metastatic Melanoma after Transfer of Autologous T Cells Recognizing 10 Mutated Tumor AntigensGene Name (from Reference) HELZ2
Checkpoint
Blockade
None
ACT
Y
Vaccination
N
Curative
Effect
durable regression
minimal_peptide
Y
Antigen
Type
TMG RNA
T-cell
Source
PBMCs
APC
Type
B cells
Assay
None