Immunogenicity 15724
Sample ID
CGLU116
Response
Positive
Tumor Type
Lung cancer
Gene Symbol
HELB
Transcript ID
None
HLA INFO
C*15:02
TCR INFO
CDR3BCAISEDPNSPLHF
Full length protein sequence (1087 aa)
MARSS
1
PYLRQ
6
LQGPL
11
LPPRD
16
LVEED
21
DDYLN
26
DDVEE
31
DEESV
36
FIDAE
41
ELCSG
46
GVKAG
51
SLPGC
56
LRVSI
61
CDENT
66
QETCK
71
VFGRF
76
PITGA
81
WWRVK
86
VQVKP
91
VVGSR
96
SYQYQ
101
VQGFP
106
SYFLQ
111
SDMSP
116
PNQKH
121
ICALF
126
LKECE
131
VSSDD
136
VNKFL
141
TWVKE
146
VSNYK
151
NLNFE
156
NLRET
161
LRTFH
166
KETGR
171
KDQKQ
176
PTQNG
181
QEELF
186
LDNEM
191
SLPLE
196
NTIPF
201
RNVMT
206
ALQFP
211
KIMEF
216
LPVLL
221
PRHFK
226
WIIGS
231
GSKEM
236
LKEIE
241
EILGT
246
HPWKL
251
GFSKI
256
TYREW
261
KLLRC
266
EASWI
271
AFCQC
276
ESLLQ
281
LMTDL
286
EKNAL
291
IMYSR
296
LKQIC
301
REDGH
306
TYVEV
311
NDLTL
316
TLSNH
321
MSFHA
326
ASESL
331
KFLKD
336
IGVVT
341
YEKSC
346
VFPYD
351
LYHAE
356
RAIAF
361
SICDL
366
MKKPP
371
WHLCV
376
DVEKV
381
LASIH
386
TTKPE
391
NSSDD
396
ALNES
401
KPDEV
406
RLENP
411
VDVVD
416
TQDNG
421
DHIWT
426
NGENE
431
INAEI
436
SEVQL
441
DQDQV
446
EVPLD
451
RDQVA
456
ALEMI
461
CSNPV
466
TVISG
471
KGGCG
476
KTTIV
481
SRLFK
486
HIEQL
491
EEREV
496
KKACE
501
DFEQD
506
QNASE
511
EWITF
516
TEQSQ
521
LEADK
526
AIEVL
531
LTAPT
536
GKAAG
541
LLRQK
546
TGLHA
551
YTLCQ
556
VNYSF
561
YSWTQ
566
TMMTT
571
NKPWK
576
FSSVR
581
VLVVD
586
EGSLV
591
SVGIF
596
KSVLN
601
LLCEH
606
SKLSK
611
LIILG
616
DIRQL
621
PSIEP
626
GNLLK
631
DLFET
636
LKSRN
641
CAIEL
646
KTNHR
651
AESQL
656
IVDNA
661
TRISR
666
RQFPK
671
FDAEL
676
NISDN
681
PTLPI
686
SIQDK
691
TFIFV
696
RLPEE
701
DASSQ
706
SSKTN
711
HHSCL
716
YSAVK
721
TLLQE
726
NNLQN
731
AKTSQ
736
FIAFR
741
RQDCD
746
LINDC
751
CCKHY
756
TGHLT
761
KDHQS
766
RLVFG
771
IGDKI
776
CCTRN
781
AYLSD
786
LLPEN
791
ISGSQ
796
QNNDL
801
DASSE
806
DFSGT
811
LPDFA
816
KNKRD
821
FESNV
826
RLCNG
831
EIFFI
836
TNDVT
841
DVTFG
846
KRRSL
851
TINNM
856
AGLEV
861
TVDFK
866
KLMKY
871
CRIKH
876
AWART
881
IHTFQ
886
GSEEQ
891
TVVYV
896
VGKAG
901
RQHWQ
906
HVYTA
911
VTRGR
916
CRVYV
921
IAEES
926
QLRNA
931
IMKNS
936
FPRKT
941
RLKHF
946
LQSKL
951
SSSGA
956
PPADF
961
PSPRK
966
SSGDS
971
GGPST
976
PSASP
981
LPVVT
986
DHAMT
991
NDVTW
996
SEASS
1001
PDERT
1006
LTFAE
1011
RWQLS
1016
SPDGV
1021
DTDDD
1026
LPKSR
1031
ASKRT
1036
CGVND
1041
DESPS
1046
KIFMV
1051
GESPQ
1056
VSSRL
1061
QNLRL
1066
NNLIP
1071
RQLFK
1076
PTDNQ
1081
ET
1086
Mutation Information
DNA mutation:
None
Peptide Range:
979 ~ 988
Mut AA position:
987 (9 in Wild Type peptide)
Alignment
Wild Type:
"STPSASPLPV
||||||||.|
Mutant:
STPSASPLSV"
Cancer Discov, 2017
Evolution of Neoantigen Landscape during Immune Checkpoint Blockade in Non-small Cell Lung CancerGene Name (from Reference) HELB
Checkpoint
Blockade
nivolumab/ipilimumab
ACT
N
Vaccination
N
Curative
Effect
partial response
minimal_peptide
Y
Antigen
Type
peptide
T-cell
Source
PBMCs
APC
Type
None
Assay
None