Immunogenicity 1573

summary
Sample ID
3971
Response
Negative
Tumor Type
Colon cancer
Gene Symbol
USP6
Transcript ID
ENST00000250066
HLA INFO
DQA*01:03 / DQB*02:05
TCR INFO

No TCR info found!

T cell Tumor cell { DQA*01:03 DQB*02:05
sequence
Full length protein sequence (1406 aa)
MDMVE
1
NADSL
6
QAQER
11
KDILM
16
KYDKG
21
HRAGL
26
PEDKG
31
PEPVG
36
INSSI
41
DRFGI
46
LHETE
51
LPPVT
56
AREAK
61
KIRRE
66
MTRTS
71
KWMEM
76
LGEWE
81
TYKHS
86
SKLID
91
RVYKG
96
IPMNI
101
RGPVW
106
SVLLN
111
IQEIK
116
LKNPG
121
RYQIM
126
KERGK
131
RSSEH
136
IHHID
141
LDVRT
146
TLRNH
151
VFFRD
156
RYGAK
161
QRELF
166
YILLA
171
YSEYN
176
PEVGY
181
CRDLS
186
HITAL
191
FLLYL
196
PEEDA
201
FWALV
206
QLLAS
211
ERHSL
216
PGFHS
221
PNGGT
226
VQGLQ
231
DQQEH
236
VVPKS
241
QPKTM
246
WHQDK
251
EGLCG
256
QCASL
261
GCLLR
266
NLIDG
271
ISLGL
276
TLRLW
281
DVYLV
286
EGEQV
291
LMPIT
296
SIALK
301
VQQKR
306
LMKTS
311
RCGLW
316
ARLRN
321
QFFDT
326
WAMND
331
DTVLK
336
HLRAS
341
TKKLT
346
RKQGD
351
LPPPA
356
KREQG
361
SLAPR
366
PVPAS
371
RGGKT
376
LCKGY
381
RQAPP
386
GPPAQ
391
FQRPI
396
CSASP
401
PWASR
406
FSTPC
411
PGGAV
416
REDTY
421
PVGTQ
426
GVPSL
431
ALAQG
436
GPQGS
441
WRFLE
446
WKSMP
451
RLPTD
456
LDIGG
461
PWFPH
466
YDFEW
471
SCWVR
476
AISQE
481
DQLAT
486
CWQAE
491
HCGEV
496
HNKDM
501
SWPEE
506
MSFTA
511
NSSKI
516
DRQKV
521
PTEKG
526
ATGLS
531
NLGNT
536
CFMNS
541
SIQCV
546
SNTQP
551
LTQYF
556
ISGRH
561
LYELN
566
RTNPI
571
GMKGH
576
MAKCY
581
GDLVQ
586
ELWSG
591
TQKSV
596
APLKL
601
RRTIA
606
KYAPK
611
FDGFQ
616
QQDSQ
621
ELLAF
626
LLDGL
631
HEDLN
636
RVHEK
641
PYVEL
646
KDSDG
651
RPDWE
656
VAAEA
661
WDNHL
666
RRNRS
671
IIVDL
676
FHGQL
681
RSQVK
686
CKTCG
691
HISVR
696
FDPFN
701
FLSLP
706
LPMDS
711
YMDLE
716
ITVIK
721
LDGTT
726
PVRYG
731
LRLNM
736
DEKYT
741
GLKKQ
746
LRDLC
751
GLNSE
756
QILLA
761
EVHDS
766
NIKNF
771
PQDNQ
776
KVQLS
781
VSGFL
786
CAFEI
791
PVPSS
796
PISAS
801
SPTQI
806
DFSSS
811
PSTNG
816
MFTLT
821
TNGDL
826
PKPIF
831
IPNGM
836
PNTVV
841
PCGTE
846
KNFTN
851
GMVNG
856
HMPSL
861
PDSPF
866
TGYII
871
AVHRK
876
MMRTE
881
LYFLS
886
PQENR
891
PSLFG
896
MPLIV
901
PCTVH
906
TRKKD
911
LYDAV
916
WIQVS
921
WLARP
926
LPPQE
931
ASIHA
936
QDRDN
941
CMGYQ
946
YPFTL
951
RVVQK
956
DGNSC
961
AWCPQ
966
YRFCR
971
GCKID
976
CGEDR
981
AFIGN
986
AYIAV
991
DWHPT
996
ALHLR
1001
YQTSQ
1006
ERVVD
1011
KHESV
1016
EQSRR
1021
AQAEP
1026
INLDS
1031
CLRAF
1036
TSEEE
1041
LGESE
1046
MYYCS
1051
KCKTH
1056
CLATK
1061
KLDLW
1066
RLPPF
1071
LIIHL
1076
KRFQF
1081
VNDQW
1086
IKSQK
1091
IVRFL
1096
RESFD
1101
PSAFL
1106
VPRDP
1111
ALCQH
1116
KPLTP
1121
QGDEL
1126
SKPRI
1131
LAREV
1136
KKVDA
1141
QSSAG
1146
KEDML
1151
LSKSP
1156
SSLSA
1161
NISSS
1166
PKGSP
1171
SSSRK
1176
SGTSC
1181
PSSKN
1186
SSPNS
1191
SPRTL
1196
GRSKG
1201
RLRLP
1206
QIGSK
1211
NKPSS
1216
SKKNL
1221
DASKE
1226
NGAGQ
1231
ICELA
1236
DALSR
1241
GHMRG
1246
GSQPE
1251
LVTPQ
1256
DHEVA
1261
LANGF
1266
LYEHE
1271
ACGNG
1276
CGDGY
1281
SNGQL
1286
GNHSE
1291
EDSTD
1296
DQRED
1301
THIKP
1306
IYNLY
1311
AISCH
1316
SGILS
1321
GGHYI
1326
TYAKN
1331
PNCKW
1336
YCYND
1341
SSCEE
1346
LHPDE
1351
IDTDS
1356
AYILF
1361
YEQQG
1366
IDYAQ
1371
FLPKI
1376
DGKKM
1381
ADTSS
1386
TDEDS
1391
ESDYE
1396
KYSML
1401
Q
1406
Mutation Information
DNA mutation:
None
Peptide Range:
109 ~ 133
Mut AA position:
121 (13 in Wild Type peptide)
Alignment
Wild Type:
"VWSVLLNIQEIKLKNPGRYQIMKER
||||||||||||.||||||||||||
Mutant:
VWSVLLNIQEIKSKNPGRYQIMKER"
reference

Science, 2015

Immunogenicity of somatic mutations in human gastrointestinal cancers

Gene Name (from Reference) USP6

clinic trial
Checkpoint Blockade

None

ACT

None

Vaccination

None

Curative Effect

None

experiment
minimal_peptide

None

Antigen Type

TMG RNA

T-cell Source

TILs

APC Type

autologous DCs

Assay

IFNg ELISPOT assay