Immunogenicity 15742

summary
Sample ID
4032
Response
Positive
Tumor Type
Colorectal cancer
Gene Symbol
PHLPP1 (FPKM: 6.4)
Transcript ID
None
HLA INFO
A*02:01
TCR INFO

No TCR info found!

T cell Tumor cell A*02:01
sequence
Full length protein sequence (1109 aa)
MEPAA
1
AATVQ
6
RLPEL
11
GREDR
16
ASAPA
21
AAAAA
26
AAAAA
31
AAAAA
36
LAAAA
41
GGGRS
46
PEPAL
51
TPAAP
56
SGGNG
61
SGSGA
66
REEAP
71
GEAPP
76
GPLPG
81
RAGGA
86
GRRRR
91
RGAPQ
96
PIAGG
101
AAPVP
106
GAGGG
111
ANSLL
116
LRRGR
121
LKRNL
126
SAAAA
131
AASSS
136
SSSSA
141
AAASH
146
SPGAA
151
GLPAS
156
CSASA
161
SLCTR
166
SLDRK
171
TLLLK
176
HRQTL
181
QLQPS
186
DRDWV
191
RHQLQ
196
RGCVH
201
VFDRH
206
MASTY
211
LRPVL
216
CTLDT
221
TAGEV
226
AARLL
231
QLGHK
236
GGGVV
241
KVLGQ
246
GPGAA
251
AAREP
256
AEPPP
261
EAGPR
266
LAPPE
271
PRDSE
276
VPPAR
281
SAPGA
286
FGGPP
291
RAPPA
296
DLPLP
301
VGGPG
306
GWSRR
311
ASPAP
316
SDSSP
321
GEPFV
326
GGPVS
331
SPRAP
336
RPVVS
341
DTESF
346
SLSPS
351
AESVS
356
DRLDP
361
YSSGG
366
GSSSS
371
SEELE
376
ADAAS
381
APTGV
386
PGQPR
391
RPGHP
396
AQPLP
401
LPQTA
406
SSPQP
411
QQKAP
416
RAIDS
421
PGGAV
426
REGSC
431
EEKAA
436
AAVAP
441
GGLQS
446
TPGRS
451
GVTAE
456
KAPPP
461
PPPPT
466
LYVQL
471
HGETT
476
RRLEA
481
EEKPL
486
QIQND
491
YLFQL
496
GFGEL
501
WRVQE
506
EGMDS
511
EIGCL
516
IRFYA
521
GKPHS
526
TGSSE
531
RIQLS
536
GMYNV
541
RKGKM
546
QLPVN
551
RWTRR
556
QVILC
561
GTCLI
566
VSSVK
571
DSLTG
576
KMHVL
581
PLIGG
586
KVEEV
591
KKHQH
596
CLAFS
601
SSGPQ
606
SQTYY
611
ICFDT
616
FTEYL
621
RWLRQ
626
VSKVA
631
SQRIS
636
SVDLS
641
CCSLE
646
HLPAN
651
LFYSQ
656
DLTHL
661
NLKQN
666
FLRQN
671
PSLPA
676
ARGLN
681
ELQRF
686
TKLKS
691
LNLSN
696
NHLGD
701
FPLAV
706
CSIPT
711
LAELN
716
VSCNA
721
LRSVP
726
AAVGV
731
MHNLQ
736
TFLLD
741
GNFLQ
746
SLPAE
751
LENMK
756
QLSYL
761
GLSFN
766
EFTDI
771
PEVLE
776
KLTAV
781
DKLCM
786
SGNCV
791
ETLRL
796
QALRK
801
MPHIK
806
HVDLR
811
LNVIR
816
KLIAD
821
EVDFL
826
QHVTQ
831
LDLRD
836
NKLGD
841
LDAMI
846
FNNIE
851
VLHCE
856
RNQLV
861
TLDIC
866
GYFLK
871
ALYAS
876
SNELV
881
QLDVY
886
PVPNY
891
LSYMD
896
VSRNR
901
LENVP
906
EWVCE
911
SRKLE
916
VLDIG
921
HNQIC
926
ELPAR
931
LFCNS
936
SLRKL
941
LAGHN
946
QLARL
951
PERLE
956
RTSVE
961
VLDVQ
966
HNQLL
971
ELPPN
976
LLMKA
981
DSLRF
986
LNASA
991
NKLES
996
LPPAT
1001
LSEET
1006
NSILQ
1011
ELYLT
1016
NNSLT
1021
DKCVP
1026
LLTGH
1031
PHLKI
1036
LHMAY
1041
NRLQS
1046
FPASK
1051
MAKLE
1056
ELEEI
1061
DLSGN
1066
KLKAI
1071
PTTIM
1076
NCRRM
1081
HTVIA
1086
HSNCI
1091
EVFPE
1096
VMQLP
1101
EIKD
1106
Mutation Information
DNA mutation:
None
Peptide Range:
563 ~ 571
Mut AA position:
566 (4 in Wild Type peptide)
Alignment
Wild Type:
"ILCGTCLIV
|||.|||||
Mutant:
ILCETCLIV"
reference

Science, 2015

Immunogenicity of somatic mutations in human gastrointestinal cancers

Gene Name (from Reference) PHLPP1

clinic trial
Checkpoint Blockade

None

ACT

N

Vaccination

N

Curative Effect

no objective response

experiment
minimal_peptide

Y

Antigen Type

peptide

T-cell Source

TILs

APC Type

DCs

Assay

None