Immunogenicity 15743

summary
Sample ID
3971
Response
Positive
Tumor Type
Colorectal cancer
Gene Symbol
CASP8 (FPKM: 6.1)
Transcript ID
None
HLA INFO
B*08:01
TCR INFO

CDR3ACAVRDRGTGGFKTI

TRBVBV28

TRAVAV1-2

CDR3BCASITKDRAYEQY

T cell Tumor cell B*08:01
sequence
Full length protein sequence (479 aa)
MDFSR
1
NLYDI
6
GEQLD
11
SEDLA
16
SLKFL
21
SLDYI
26
PQRKQ
31
EPIKD
36
ALMLF
41
QRLQE
46
KRMLE
51
ESNLS
56
FLKEL
61
LFRIN
66
RLDLL
71
ITYLN
76
TRKEE
81
MEREL
86
QTPGR
91
AQISA
96
YRVML
101
YQISE
106
EVSRS
111
ELRSF
116
KFLLQ
121
EEISK
126
CKLDD
131
DMNLL
136
DIFIE
141
MEKRV
146
ILGEG
151
KLDIL
156
KRVCA
161
QINKS
166
LLKII
171
NDYEE
176
FSKER
181
SSSLE
186
GSPDE
191
FSNGE
196
ELCGV
201
MTISD
206
SPREQ
211
DSESQ
216
TLDKV
221
YQMKS
226
KPRGY
231
CLIIN
236
NHNFA
241
KAREK
246
VPKLH
251
SIRDR
256
NGTHL
261
DAGAL
266
TTTFE
271
ELHFE
276
IKPHD
281
DCTVE
286
QIYEI
291
LKIYQ
296
LMDHS
301
NMDCF
306
ICCIL
311
SHGDK
316
GIIYG
321
TDGQE
326
APIYE
331
LTSQF
336
TGLKC
341
PSLAG
346
KPKVF
351
FIQAC
356
QGDNY
361
QKGIP
366
VETDS
371
EEQPY
376
LEMDL
381
SSPQT
386
RYIPD
391
EADFL
396
LGMAT
401
VNNCV
406
SYRNP
411
AEGTW
416
YIQSL
421
CQSLR
426
ERCPR
431
GDDIL
436
TILTE
441
VNYEV
446
SNKDD
451
KKNMG
456
KQMPQ
461
PTFTL
466
RKKLV
471
FPSD
476
Mutation Information
DNA mutation:
None
Peptide Range:
64 ~ 72
Mut AA position:
67 (4 in Wild Type peptide)
Alignment
Wild Type:
"ELLFRINRL
|||.|||||
Mutant:
ELLVRINRL"
reference

Science, 2015

Immunogenicity of somatic mutations in human gastrointestinal cancers

Gene Name (from Reference) CASP8

clinic trial
Checkpoint Blockade

None

ACT

N

Vaccination

N

Curative Effect

None

experiment
minimal_peptide

Y

Antigen Type

peptide

T-cell Source

TILs

APC Type

DCs

Assay

None