Immunogenicity 15821

summary
Sample ID
P04-FLNA-P369L
Response
Positive
Tumor Type
Melanoma
Gene Symbol
FLNA
Transcript ID
None
HLA INFO
A*02:01
TCR INFO

TRAJAJ37*02

TRBVBV9

TRBDBD2

TRBJBJ2-7

TRAVAV29

T cell Tumor cell A*02:01
sequence
Full length protein sequence (2647 aa)
MSSSH
1
SRAGQ
6
SAAGA
11
APGGG
16
VDTRD
21
AEMPA
26
TEKDL
31
AEDAP
36
WKKIQ
41
QNTFT
46
RWCNE
51
HLKCV
56
SKRIA
61
NLQTD
66
LSDGL
71
RLIAL
76
LEVLS
81
QKKMH
86
RKHNQ
91
RPTFR
96
QMQLE
101
NVSVA
106
LEFLD
111
RESIK
116
LVSID
121
SKAIV
126
DGNLK
131
LILGL
136
IWTLI
141
LHYSI
146
SMPMW
151
DEEED
156
EEAKK
161
QTPKQ
166
RLLGW
171
IQNKL
176
PQLPI
181
TNFSR
186
DWQSG
191
RALGA
196
LVDSC
201
APGLC
206
PDWDS
211
WDASK
216
PVTNA
221
REAMQ
226
QADDW
231
LGIPQ
236
VITPE
241
EIVDP
246
NVDEH
251
SVMTY
256
LSQFP
261
KAKLK
266
PGAPL
271
RPKLN
276
PKKAR
281
AYGPG
286
IEPTG
291
NMVKK
296
RAEFT
301
VETRS
306
AGQGE
311
VLVYV
316
EDPAG
321
HQEEA
326
KVTAN
331
NDKNR
336
TFSVW
341
YVPEV
346
TGTHK
351
VTVLF
356
AGQHI
361
AKSPF
366
EVYVD
371
KSQGD
376
ASKVT
381
AQGPG
386
LEPSG
391
NIANK
396
TTYFE
401
IFTAG
406
AGTGE
411
VEVVI
416
QDPMG
421
QKGTV
426
EPQLE
431
ARGDS
436
TYRCS
441
YQPTM
446
EGVHT
451
VHVTF
456
AGVPI
461
PRSPY
466
TVTVG
471
QACNP
476
SACRA
481
VGRGL
486
QPKGV
491
RVKET
496
ADFKV
501
YTKGA
506
GSGEL
511
KVTVK
516
GPKGE
521
ERVKQ
526
KDLGD
531
GVYGF
536
EYYPM
541
VPGTY
546
IVTIT
551
WGGQN
556
IGRSP
561
FEVKV
566
GTECG
571
NQKVR
576
AWGPG
581
LEGGV
586
VGKSA
591
DFVVE
596
AIGDD
601
VGTLG
606
FSVEG
611
PSQAK
616
IECDD
621
KGDGS
626
CDVRY
631
WPQEA
636
GEYAV
641
HVLCN
646
SEDIR
651
LSPFM
656
ADIRD
661
APQDF
666
HPDRV
671
KARGP
676
GLEKT
681
GVAVN
686
KPAEF
691
TVDAK
696
HGGKA
701
PLRVQ
706
VQDNE
711
GCPVE
716
ALVKD
721
NGNGT
726
YSCSY
731
VPRKP
736
VKHTA
741
MVSWG
746
GVSIP
751
NSPFR
756
VNVGA
761
GSHPN
766
KVKVY
771
GPGVA
776
KTGLK
781
AHEPT
786
YFTVD
791
CAEAG
796
QGDVS
801
IGIKC
806
APGVV
811
GPAEA
816
DIDFD
821
IIRND
826
NDTFT
831
VKYTP
836
RGAGS
841
YTIMV
846
LFADQ
851
ATPTS
856
PIRVK
861
VEPSH
866
DASKV
871
KAEGP
876
GLSRT
881
GVELG
886
KPTHF
891
TVNAK
896
AAGKG
901
KLDVQ
906
FSGLT
911
KGDAV
916
RDVDI
921
IDHHD
926
NTYTV
931
KYTPV
936
QQGPV
941
GVNVT
946
YGGDP
951
IPKSP
956
FSVAV
961
SPSLD
966
LSKIK
971
VSGLG
976
EKVDV
981
GKDQE
986
FTVKS
991
KGAGG
996
QGKVA
1001
SKIVG
1006
PSGAA
1011
VPCKV
1016
EPGLG
1021
ADNSV
1026
VRFLP
1031
REEGP
1036
YEVEV
1041
TYDGV
1046
PVPGS
1051
PFPLE
1056
AVAPT
1061
KPSKV
1066
KAFGP
1071
GLQGG
1076
SAGSP
1081
ARFTI
1086
DTKGA
1091
GTGGL
1096
GLTVE
1101
GPCEA
1106
QLECL
1111
DNGDG
1116
TCSVS
1121
YVPTE
1126
PGDYN
1131
INILF
1136
ADTHI
1141
PGSPF
1146
KAHVV
1151
PCFDA
1156
SKVKC
1161
SGPGL
1166
ERATA
1171
GEVGQ
1176
FQVDC
1181
SSAGS
1186
AELTI
1191
EICSE
1196
AGLPA
1201
EVYIQ
1206
DHGDG
1211
THTIT
1216
YIPLC
1221
PGAYT
1226
VTIKY
1231
GGQPV
1236
PNFPS
1241
KLQVE
1246
PAVDT
1251
SGVQC
1256
YGPGI
1261
EGQGV
1266
FREAT
1271
TEFSV
1276
DARAL
1281
TQTGG
1286
PHVKA
1291
RVANP
1296
SGNLT
1301
ETYVQ
1306
DRGDG
1311
MYKVE
1316
YTPYE
1321
EGLHS
1326
VDVTY
1331
DGSPV
1336
PSSPF
1341
QVPVT
1346
EGCDP
1351
SRVRV
1356
HGPGI
1361
QSGTT
1366
NKPNK
1371
FTVET
1376
RGAGT
1381
GGLGL
1386
AVEGP
1391
SEAKM
1396
SCMDN
1401
KDGSC
1406
SVEYI
1411
PYEAG
1416
TYSLN
1421
VTYGG
1426
HQVPG
1431
SPFKV
1436
PVHDV
1441
TDASK
1446
VKCSG
1451
PGLSP
1456
GMVRA
1461
NLPQS
1466
FQVDT
1471
SKAGV
1476
APLQV
1481
KVQGP
1486
KGLVE
1491
PVDVV
1496
DNADG
1501
TQTVN
1506
YVPSR
1511
EGPYS
1516
ISVLY
1521
GDEEV
1526
PRSPF
1531
KVKVL
1536
PTHDA
1541
SKVKA
1546
SGPGL
1551
NTTGV
1556
PASLP
1561
VEFTI
1566
DAKDA
1571
GEGLL
1576
AVQIT
1581
DPEGK
1586
PKKTH
1591
IQDNH
1596
DGTYT
1601
VAYVP
1606
DVTGR
1611
YTILI
1616
KYGGD
1621
EIPFS
1626
PYRVR
1631
AVPTG
1636
DASKC
1641
TVTVS
1646
IGGHG
1651
LGAGI
1656
GPTIQ
1661
IGEET
1666
VITVD
1671
TKAAG
1676
KGKVT
1681
CTVCT
1686
PDGSE
1691
VDVDV
1696
VENED
1701
GTFDI
1706
FYTAP
1711
QPGKY
1716
VICVR
1721
FGGEH
1726
VPNSP
1731
FQVTA
1736
LAGDQ
1741
PSVQP
1746
PLRSQ
1751
QLAPQ
1756
YTYAQ
1761
GGQQT
1766
WAPER
1771
PLVGV
1776
NGLDV
1781
TSLRP
1786
FDLVI
1791
PFTIK
1796
KGEIT
1801
GEVRM
1806
PSGKV
1811
AQPTI
1816
TDNKD
1821
GTVTV
1826
RYAPS
1831
EAGLH
1836
EMDIR
1841
YDNMH
1846
IPGSP
1851
LQFYV
1856
DYVNC
1861
GHVTA
1866
YGPGL
1871
THGVV
1876
NKPAT
1881
FTVNT
1886
KDAGE
1891
GGLSL
1896
AIEGP
1901
SKAEI
1906
SCTDN
1911
QDGTC
1916
SVSYL
1921
PVLPG
1926
DYSIL
1931
VKYNE
1936
QHVPG
1941
SPFTA
1946
RVTGD
1951
DSMRM
1956
SHLKV
1961
GSAAD
1966
IPINI
1971
SETDL
1976
SLLTA
1981
TVVPP
1986
SGREE
1991
PCLLK
1996
RLRNG
2001
HVGIS
2006
FVPKE
2011
TGEHL
2016
VHVKK
2021
NGQHV
2026
ASSPI
2031
PVVIS
2036
QSEIG
2041
DASRV
2046
RVSGQ
2051
GLHEG
2056
HTFEP
2061
AEFII
2066
DTRDA
2071
GYGGL
2076
SLSIE
2081
GPSKV
2086
DINTE
2091
DLEDG
2096
TCRVT
2101
YCPTE
2106
PGNYI
2111
INIKF
2116
ADQHV
2121
PGSPF
2126
SVKVT
2131
GEGRV
2136
KESIT
2141
RRRRA
2146
PSVAN
2151
VGSHC
2156
DLSLK
2161
IPEIS
2166
IQDMT
2171
AQVTS
2176
PSGKT
2181
HEAEI
2186
VEGEN
2191
HTYCI
2196
RFVPA
2201
EMGTH
2206
TVSVK
2211
YKGQH
2216
VPGSP
2221
FQFTV
2226
GPLGE
2231
GGAHK
2236
VRAGG
2241
PGLER
2246
AEAGV
2251
PAEFS
2256
IWTRE
2261
AGAGG
2266
LAIAV
2271
EGPSK
2276
AEISF
2281
EDRKD
2286
GSCGV
2291
AYVVQ
2296
EPGDY
2301
EVSVK
2306
FNEEH
2311
IPDSP
2316
FVVPV
2321
ASPSG
2326
DARRL
2331
TVSSL
2336
QESGL
2341
KVNQP
2346
ASFAV
2351
SLNGA
2356
KGAID
2361
AKVHS
2366
PSGAL
2371
EECYV
2376
TEIDQ
2381
DKYAV
2386
RFIPR
2391
ENGVY
2396
LIDVK
2401
FNGTH
2406
IPGSP
2411
FKIRV
2416
GEPGH
2421
GGDPG
2426
LVSAY
2431
GAGLE
2436
GGVTG
2441
NPAEF
2446
VVNTS
2451
NAGAG
2456
ALSVT
2461
IDGPS
2466
KVKMD
2471
CQECP
2476
EGYRV
2481
TYTPM
2486
APGSY
2491
LISIK
2496
YGGPY
2501
HIGGS
2506
PFKAK
2511
VTGPR
2516
LVSNH
2521
SLHET
2526
SSVFV
2531
DSLTK
2536
ATCAP
2541
QHGAP
2546
GPGPA
2551
DASKV
2556
VAKGL
2561
GLSKA
2566
YVGQK
2571
SSFTV
2576
DCSKA
2581
GNNML
2586
LVGVH
2591
GPRTP
2596
CEEIL
2601
VKHVG
2606
SRLYS
2611
VSYLL
2616
KDKGE
2621
YTLVV
2626
KWGDE
2631
HIPGS
2636
PYRVV
2641
VP
2646
Mutation Information
DNA mutation:
None
Peptide Range:
364 ~ 372
Mut AA position:
369 (6 in Wild Type peptide)
Alignment
Wild Type:
"HIAKSPFEV
|||||.|||
Mutant:
HIAKSLFEV"
reference
clinic trial
Checkpoint Blockade

None

ACT

N

Vaccination

Y

Curative Effect

Metastasis

experiment
minimal_peptide

Y

Antigen Type

multimer

T-cell Source

PBL

APC Type

multimer

Assay

None