Immunogenicity 15836

summary
Sample ID
patient1
Response
Positive
Tumor Type
Melanoma
Gene Symbol
KMT2D (FPKM: 481422)
Transcript ID
None
HLA INFO
A*02:01
TCR INFO

TRAJAJ10

CDR3ACAVGEAGGGNKLTF

TRBVBV4-1

TRBDBJ2-2 TRBD1

TRBJBJ2-2

CDR3BCASSYDSTTGELFF

T cell Tumor cell A*02:01
sequence
Full length protein sequence (5553 aa)
MDSQK
1
LAGED
6
KDSEP
11
AADGP
16
AASED
21
PSATE
26
SDLPN
31
PHVGE
36
VSVLS
41
SGSPR
46
LQETP
51
QDCSG
56
GPVRR
61
CALCN
66
CGEPS
71
LHGQR
76
ELRRF
81
ELPFD
86
WPRCP
91
VVSPG
96
GSPGP
101
NEAVL
106
PSEDL
111
SQIGF
116
PEGLT
121
PAHLG
126
EPGGS
131
CWAHH
136
WCAAW
141
SAGVW
146
GQEGP
151
ELCGV
156
DKAIF
161
SGISQ
166
RCSHC
171
TRLGA
176
SIPCR
181
SPGCP
186
RLYHF
191
PCATA
196
SGSFL
201
SMKTL
206
QLLCP
211
EHSEG
216
AAYLE
221
EARCA
226
VCEGP
231
GELCD
236
LFFCT
241
SCGHH
246
YHGAC
251
LDTAL
256
TARKR
261
AGWQC
266
PECKV
271
CQACR
276
KPGND
281
SKMLV
286
CETCD
291
KGYHT
296
FCLKP
301
PMEEL
306
PAHSW
311
KCKAC
316
RVCRA
321
CGAGS
326
AELNP
331
NSEWF
336
ENYSL
341
CHRCH
346
KAQGG
351
QTIRS
356
VAEQH
361
TPVCS
366
RFSPP
371
EPGDT
376
PTDEP
381
DALYV
386
ACQGQ
391
PKGGH
396
VTSMQ
401
PKEPG
406
PLQCE
411
AKPLG
416
KAGVQ
421
LEPQL
426
EAPLN
431
EEMPL
436
LPPPE
441
ESPLS
446
PPPEE
451
SPTSP
456
PPEAS
461
RLSPP
466
PEELP
471
ASPLP
476
EALHL
481
SRPLE
486
ESPLS
491
PPPEE
496
SPLSP
501
PPESS
506
PFSPL
511
EESPL
516
SPPEE
521
SPPSP
526
ALETP
531
LSPPP
536
EASPL
541
SPPFE
546
ESPLS
551
PPPEE
556
LPTSP
561
PPEAS
566
RLSPP
571
PEESP
576
MSPPP
581
EESPM
586
SPPPE
591
ASRLF
596
PPFEE
601
SPLSP
606
PPEES
611
PLSPP
616
PEASR
621
LSPPP
626
EDSPM
631
SPPPE
636
ESPMS
641
PPPEV
646
SRLSP
651
LPVVS
656
RLSPP
661
PEESP
666
LSPPP
671
EESPT
676
SPPPE
681
ASRLS
686
PPPED
691
SPTSP
696
PPEDS
701
PASPP
706
PEDSL
711
MSLPL
716
EESPL
721
LPLPE
726
EPQLC
731
PRSEG
736
PHLSP
741
RPEEP
746
HLSPR
751
PEEPH
756
LSPQA
761
EEPHL
766
SPQPE
771
EPCLC
776
AVPEE
781
PHLSP
786
QAEGP
791
HLSPQ
796
PEELH
801
LSPQT
806
EEPHL
811
SPVPE
816
EPCLS
821
PQPEE
826
SHLSP
831
QSEEP
836
CLSPR
841
PEESH
846
LSPEL
851
EKPPL
856
SPRPE
861
KPPEE
866
PGQCP
871
APEEL
876
PLFPP
881
PGEPS
886
LSPLL
891
GEPAL
896
SEPGE
901
PPLSP
906
LPEEL
911
PLSPS
916
GEPSL
921
SPQLM
926
PPDPL
931
PPPLS
936
PIITA
941
AAPPA
946
LSPLG
951
ELEYP
956
FGAKG
961
DSDPE
966
SPLAA
971
PILET
976
PISPP
981
PEANC
986
TDPEP
991
VPPMI
996
LPPSP
1001
GSPVG
1006
PASPI
1011
LMEPL
1016
PPQCS
1021
PLLQH
1026
SLVPQ
1031
NSPPS
1036
QCSPP
1041
ALPLS
1046
VPSPL
1051
SPIGK
1056
VVGVS
1061
DEAEL
1066
HEMET
1071
EKVSE
1076
PECPA
1081
LEPSA
1086
TSPLP
1091
SPMGD
1096
LSCPA
1101
PSPAP
1106
ALDDF
1111
SGLGE
1116
DTAPL
1121
DGIDA
1126
PGSQP
1131
EPGQT
1136
PGSLA
1141
SELKG
1146
SPVLL
1151
DPEEL
1156
APVTP
1161
MEVYP
1166
ECKQT
1171
AGQGS
1176
PCEEQ
1181
EEPRA
1186
PVAPT
1191
PPTLI
1196
KSDIV
1201
NEISN
1206
LSQGD
1211
ASASF
1216
PGSEP
1221
LLGSP
1226
DPEGG
1231
GSLSM
1236
ELGVS
1241
TDVSP
1246
ARDEG
1251
SLRLC
1256
TDSLP
1261
ETDDS
1266
LLCDA
1271
GTAIS
1276
GGKAE
1281
GEKGR
1286
RRSSP
1291
ARSRI
1296
KQGRS
1301
SSFPG
1306
RRRPR
1311
GGAHG
1316
GRGRG
1321
RARLK
1326
STASS
1331
IETLV
1336
VADID
1341
SSPSK
1346
EEEEE
1351
DDDTM
1356
QNTVV
1361
LFSNT
1366
DKFVL
1371
MQDMC
1376
VVCGS
1381
FGRGA
1386
EGHLL
1391
ACSQC
1396
SQCYH
1401
PYCVN
1406
SKITK
1411
VMLLK
1416
GWRCV
1421
ECIVC
1426
EVCGQ
1431
ASDPS
1436
RLLLC
1441
DDCDI
1446
SYHTY
1451
CLDPP
1456
LLTVP
1461
KGGWK
1466
CKWCV
1471
SCMQC
1476
GAASP
1481
GFHCE
1486
WQNSY
1491
THCGP
1496
CASLV
1501
TCPIC
1506
HAPYV
1511
EEDLL
1516
IQCRH
1521
CERWM
1526
HAGCE
1531
SLFTE
1536
DDVEQ
1541
AADEG
1546
FDCVS
1551
CQPYV
1556
VKPVA
1561
PVAPP
1566
ELVPM
1571
KVKEP
1576
EPQYF
1581
RFEGV
1586
WLTET
1591
GMALL
1596
RNLTM
1601
SPLHK
1606
RRQRR
1611
GRLGL
1616
PGEAG
1621
LEGSE
1626
PSDAL
1631
GPDDK
1636
KDGDL
1641
DTDEL
1646
LKGEG
1651
GVEHM
1656
ECEIK
1661
LEGPV
1666
SPDVE
1671
PGKEE
1676
TEESK
1681
KRKRK
1686
PYRPG
1691
IGGFM
1696
VRQRK
1701
SHTRT
1706
KKGPA
1711
AQAEV
1716
LSGDG
1721
QPDEV
1726
IPADL
1731
PAEGA
1736
VEQSL
1741
AEGDE
1746
KKKQQ
1751
RRGRK
1756
KSKLE
1761
DMFPA
1766
YLQEA
1771
FFGKE
1776
LLDLS
1781
RKALF
1786
AVGVG
1791
RPSFG
1796
LGTPK
1801
AKGDG
1806
GSERK
1811
ELPTS
1816
QKGDD
1821
GPDIA
1826
DEESR
1831
GLEGK
1836
ADTPG
1841
PEDGG
1846
VKASP
1851
VPSDP
1856
EKPGT
1861
PGEGM
1866
LSSDL
1871
DRIST
1876
EELPK
1881
MESKD
1886
LQQLF
1891
KDVLG
1896
SEREQ
1901
HLGCG
1906
TPGLE
1911
GSRTP
1916
LQRPF
1921
LQGGL
1926
PLGNL
1931
PSSSP
1936
MDSYP
1941
GLCQS
1946
PFLDS
1951
RERGG
1956
FFSPE
1961
PGEPD
1966
SPWTG
1971
SGGTT
1976
PSTPT
1981
TPTTE
1986
GEGDG
1991
LSYNQ
1996
RSLQR
2001
WEKDE
2006
ELGQL
2011
STISP
2016
VLYAN
2021
INFPN
2026
LKQDY
2031
PDWSS
2036
RCKQI
2041
MKLWR
2046
KVPAA
2051
DKAPY
2056
LQKAK
2061
DNRAA
2066
HRINK
2071
VQKQA
2076
ESQIN
2081
KQTKV
2086
GDIAR
2091
KTDRP
2096
ALHLR
2101
IPPQP
2106
GALGS
2111
PPPAA
2116
APTIF
2121
IGSPT
2126
TPAGL
2131
STSAD
2136
GFLKP
2141
PAGSV
2146
PGPDS
2151
PGELF
2156
LKLPP
2161
QVPAQ
2166
VPSQD
2171
PFGLA
2176
PAYPL
2181
EPRFP
2186
TAPPT
2191
YPPYP
2196
SPTGA
2201
PAQPP
2206
MLGAS
2211
SRPGA
2216
GQPGE
2221
FHTTP
2226
PGTPR
2231
HQPST
2236
PDPFL
2241
KPRCP
2246
SLDNL
2251
AVPES
2256
PGVGG
2261
GKASE
2266
PLLSP
2271
PPFGE
2276
SRKAL
2281
EVKKE
2286
ELGAS
2291
SPSYG
2296
PPNLG
2301
FVDSP
2306
SSGTH
2311
LGGLE
2316
LKTPD
2321
VFKAP
2326
LTPRA
2331
SQVEP
2336
QSPGL
2341
GLRPQ
2346
EPPPA
2351
QALAP
2356
SPPSH
2361
PDIFR
2366
PGSYT
2371
DPYAQ
2376
PPLTP
2381
RPQPP
2386
PPESC
2391
CALPP
2396
RSLPS
2401
DPFSR
2406
VPASP
2411
QSQSS
2416
SQSPL
2421
TPRPL
2426
SAEAF
2431
CPSPV
2436
TPRFQ
2441
SPDPY
2446
SRPPS
2451
RPQSR
2456
DPFAP
2461
LHKPP
2466
RPQPP
2471
EVAFK
2476
AGSLA
2481
HTSLG
2486
AGGFP
2491
AALPA
2496
GPAGE
2501
LHAKV
2506
PSGQP
2511
PNFVR
2516
SPGTG
2521
AFVGT
2526
PSPMR
2531
FTFPQ
2536
AVGEP
2541
SLKPP
2546
VPQPG
2551
LPPPH
2556
GINSH
2561
FGPGP
2566
TLGKP
2571
QSTNY
2576
TVATG
2581
NFHPS
2586
GSPLG
2591
PSSGS
2596
TGESY
2601
GLSPL
2606
RPPSV
2611
LPPPA
2616
PDGSL
2621
PYLSH
2626
GASQR
2631
SGITS
2636
PVEKR
2641
EDPGT
2646
GMGSS
2651
LATAE
2656
LPGTQ
2661
DPGMS
2666
GLSQT
2671
ELEKQ
2676
RQRQR
2681
LRELL
2686
IRQQI
2691
QRNTL
2696
RQEKE
2701
TAAAA
2706
AGAVG
2711
PPGSW
2716
GAEPS
2721
SPAFE
2726
QLSRG
2731
QTPFA
2736
GTQDK
2741
SSLVG
2746
LPPSK
2751
LSGPI
2756
LGPGS
2761
FPSDD
2766
RLSRP
2771
PPPAT
2776
PSSMD
2781
VNSRQ
2786
LVGGS
2791
QAFYQ
2796
RAPYP
2801
GSLPL
2806
QQQQQ
2811
QLWQQ
2816
QQATA
2821
ATSMR
2826
FAMSA
2831
RFPST
2836
PGPEL
2841
GRQAL
2846
GSPLA
2851
GISTR
2856
LPGPG
2861
EPVPG
2866
PAGPA
2871
QFIEL
2876
RHNVQ
2881
KGLGP
2886
GGTPF
2891
PGQGP
2896
PQRPR
2901
FYPVS
2906
EDPHR
2911
LAPEG
2916
LRGLA
2921
VSGLP
2926
PQKPS
2931
APPAP
2936
ELNNS
2941
LHPTP
2946
HTKGP
2951
TLPTG
2956
LELVN
2961
RPPSS
2966
TELGR
2971
PNPLA
2976
LEAGK
2981
LPCED
2986
PELDD
2991
DFDAH
2996
KALED
3001
DEELA
3006
HLGLG
3011
VDVAK
3016
GDDEL
3021
GTLEN
3026
LETND
3031
PHLDD
3036
LLNGD
3041
EFDLL
3046
AYTDP
3051
ELDTG
3056
DKKDI
3061
FNEHL
3066
RLVES
3071
ANEKA
3076
EREAL
3081
LRGVE
3086
PGPLG
3091
PEERP
3096
PPAAD
3101
ASEPR
3106
LASVL
3111
PEVKP
3116
KVEEG
3121
GRHPS
3126
PCQFT
3131
IATPK
3136
VEPAP
3141
AANSL
3146
GLGLK
3151
PGQSM
3156
MGSRD
3161
TRMGT
3166
GPFSS
3171
SGHTA
3176
EKASF
3181
GATGG
3186
PPAHL
3191
LTPSP
3196
LSGPG
3201
GSSLL
3206
EKFEL
3211
ESGAL
3216
TLPGG
3221
PAASG
3226
DELDK
3231
MESSL
3236
VASEL
3241
PLLIE
3246
DLLEH
3251
EKKEL
3256
QKKQQ
3261
LSAQL
3266
QPAQQ
3271
QQQQQ
3276
QQHSL
3281
LSAPG
3286
PAQAM
3291
SLPHE
3296
GSSPS
3301
LAGSQ
3306
QQLSL
3311
GLAGA
3316
RQPGL
3321
PQPLM
3326
PTQPP
3331
AHALQ
3336
QRLAP
3341
SMAMV
3346
SNQGH
3351
MLSGQ
3356
HGGQA
3361
GLVPQ
3366
QSSQP
3371
VLSQK
3376
PMGTM
3381
PPSMC
3386
MKPQQ
3391
LAMQQ
3396
QLANS
3401
FFPDT
3406
DLDKF
3411
AAEDI
3416
IDPIA
3421
KAKMV
3426
ALKGI
3431
KKVMA
3436
QGSIG
3441
VAPGM
3446
NRQQV
3451
SLLAQ
3456
RLSGG
3461
PSSDL
3466
QNHVA
3471
AGSGQ
3476
ERSAG
3481
DPSQP
3486
RPNPP
3491
TFAQG
3496
VINEA
3501
DQRQY
3506
EEWLF
3511
HTQQL
3516
LQMQL
3521
KVLEE
3526
QIGVH
3531
RKSRK
3536
ALCAK
3541
QRTAK
3546
KAGRE
3551
FPEAD
3556
AEKLK
3561
LVTEQ
3566
QSKIQ
3571
KQLDQ
3576
VRKQQ
3581
KEHTN
3586
LMAEY
3591
RNKQQ
3596
QQQQQ
3601
QQQQQ
3606
QQHSA
3611
VLALS
3616
PSQSP
3621
RLLTK
3626
LPGQL
3631
LPGHG
3636
LQPPQ
3641
GPPGG
3646
QAGGL
3651
RLTPG
3656
GMALP
3661
GQPGG
3666
PFLNT
3671
ALAQQ
3676
QQQQH
3681
SGGAG
3686
SLAGP
3691
SGGFF
3696
PGNLA
3701
LRSLG
3706
PDSRL
3711
LQERQ
3716
LQLQQ
3721
QRMQL
3726
AQKLQ
3731
QQQQQ
3736
QQQQQ
3741
HLLGQ
3746
VAIQQ
3751
QQQQG
3756
PGVQT
3761
NQALG
3766
PKPQG
3771
LMPPS
3776
SHQGL
3781
LVQQL
3786
SPQPP
3791
QGPQG
3796
MLGPA
3801
QVAVL
3806
QQQHP
3811
GALGP
3816
QGPHR
3821
QVLMT
3826
QSRVL
3831
SSPQL
3836
AQQGQ
3841
GLMGH
3846
RLVTA
3851
QQQQQ
3856
QQQHQ
3861
QQGSM
3866
AGLSH
3871
LQQSL
3876
MSHSG
3881
QPKLS
3886
AQPMG
3891
SLQQL
3896
QQQQQ
3901
LQQQQ
3906
QLQQQ
3911
QQQQL
3916
QQQQQ
3921
LQQQQ
3926
LQQQQ
3931
QQQQL
3936
QQQQQ
3941
QQLQQ
3946
QQQQL
3951
QQQQQ
3956
QQQQQ
3961
FQQQQ
3966
QQQQM
3971
GLLNQ
3976
SRTLL
3981
SPQQQ
3986
QQQQV
3991
ALGPG
3996
MPAKP
4001
LQHFS
4006
SPGAL
4011
GPTLL
4016
LTGKE
4021
QNTVD
4026
PAVSS
4031
EATEG
4036
PSTHQ
4041
GGPLA
4046
IGTTP
4051
ESMAT
4056
EPGEV
4061
KPSLS
4066
GDSQL
4071
LLVQP
4076
QPQPQ
4081
PSSLQ
4086
LQPPL
4091
RLPGQ
4096
QQQQV
4101
SLLHT
4106
AGGGS
4111
HGQLG
4116
SGSSS
4121
EASSV
4126
PHLLA
4131
QPSVS
4136
LGDQP
4141
GSMTQ
4146
NLLGP
4151
QQPML
4156
ERPMQ
4161
NNTGP
4166
QPPKP
4171
GPVLQ
4176
SGQGL
4181
PGVGI
4186
MPTVG
4191
QLRAQ
4196
LQGVL
4201
AKNPQ
4206
LRHLS
4211
PQQQQ
4216
QLQAL
4221
LMQRQ
4226
LQQSQ
4231
AVRQT
4236
PPYQE
4241
PGTQT
4246
SPLQG
4251
LLGCQ
4256
PQLGG
4261
FPGPQ
4266
TGPLQ
4271
ELGAG
4276
PRPQG
4281
PPRLP
4286
APPGA
4291
LSTGP
4296
VLGPV
4301
HPTPP
4306
PSSPQ
4311
EPKRP
4316
SQLPS
4321
PSSQL
4326
PTEAQ
4331
LPPTH
4336
PGTPK
4341
PQGPT
4346
LEPPP
4351
GRVSP
4356
AAAQL
4361
ADTLF
4366
SKGLG
4371
PWDPP
4376
DNLAE
4381
TQKPE
4386
QSSLV
4391
PGHLD
4396
QVNGQ
4401
VVPEA
4406
SQLSI
4411
KQEPR
4416
EEPCA
4421
LGAQS
4426
VKREA
4431
NGEPI
4436
GAPGT
4441
SNHLL
4446
LAGPR
4451
SEAGH
4456
LLLQK
4461
LLRAK
4466
NVQLS
4471
TGRGS
4476
EGLRA
4481
EINGH
4486
IDSKL
4491
AGLEQ
4496
KLQGT
4501
PSNKE
4506
DAAAR
4511
KPLTP
4516
KPKRV
4521
QKASD
4526
RLVSS
4531
RKKLR
4536
KEDGV
4541
RASEA
4546
LLKQL
4551
KQELS
4556
LLPLT
4561
EPAIT
4566
ANFSL
4571
FAPFG
4576
SGCPV
4581
NGQSQ
4586
LRGAF
4591
GSGAL
4596
PTGPD
4601
YYSQL
4606
LTKNN
4611
LSNPP
4616
TPPSS
4621
LPPTP
4626
PPSVQ
4631
QKMVN
4636
GVTPS
4641
EELGE
4646
HPKDA
4651
ASARD
4656
SERAL
4661
RDTSE
4666
VKSLD
4671
LLAAL
4676
PTPPH
4681
NQTED
4686
VRMES
4691
DEDSD
4696
SPDSI
4701
VPASS
4706
PESIL
4711
GEEAP
4716
RFPHL
4721
GSGRW
4726
EQEDR
4731
ALSPV
4736
IPLIP
4741
RASIP
4746
VFPDT
4751
KPYGA
4756
LGLEV
4761
PGKLP
4766
VTTWE
4771
KGKGS
4776
EVSVM
4781
LTVSA
4786
AAAKN
4791
LNGVM
4796
VAVAE
4801
LLSMK
4806
IPNSY
4811
EVLFP
4816
ESPAR
4821
AGTEP
4826
KKGEA
4831
EGPGG
4836
KEKGL
4841
EGKSP
4846
DTGPD
4851
WLKQF
4856
DAVLP
4861
GYTLK
4866
SQLDI
4871
LSLLK
4876
QESPA
4881
PEPPT
4886
QHSYT
4891
YNVSN
4896
LDVRQ
4901
LSAPP
4906
PEEPS
4911
PPPSP
4916
LAPSP
4921
ASPPT
4926
EPLVE
4931
LPTEP
4936
LAEPP
4941
VPSPL
4946
PLASS
4951
PESAR
4956
PKPRA
4961
RPPEE
4966
GEDSR
4971
PPRLK
4976
KWKGV
4981
RWKRL
4986
RLLLT
4991
IQKGS
4996
GRQED
5001
EREVA
5006
EFMEQ
5011
LGTAL
5016
RPDKV
5021
PRDMR
5026
RCCFC
5031
HEEGD
5036
GATDG
5041
PARLL
5046
NLDLD
5051
LWVHL
5056
NCALW
5061
STEVY
5066
ETQGG
5071
ALMNV
5076
EVALH
5081
RGLLT
5086
KCSLC
5091
QRTGA
5096
TSSCN
5101
RMRCP
5106
NVYHF
5111
ACAIR
5116
AKCMF
5121
FKDKT
5126
MLCPM
5131
HKIKG
5136
PCEQE
5141
LSSFA
5146
VFRRV
5151
YIERD
5156
EVKQI
5161
ASIIQ
5166
RGERL
5171
HMFRV
5176
GGLVF
5181
HAIGQ
5186
LLPHQ
5191
MADFH
5196
SATAL
5201
YPVGY
5206
EATRI
5211
YWSLR
5216
TNNRR
5221
CCYRC
5226
SIGEN
5231
NGRPE
5236
FVIKV
5241
IEQGL
5246
EDLVF
5251
TDASP
5256
QAVWN
5261
RIIEP
5266
VAAMR
5271
KEADM
5276
LRLFP
5281
EYLKG
5286
EELFG
5291
LTVHA
5296
VLRIA
5301
ESLPG
5306
VESCQ
5311
NYLFR
5316
YGRHP
5321
LMELP
5326
LMINP
5331
TGCAR
5336
SEPKI
5341
LTHYK
5346
RVFTS
5351
IISFD
5356
PHNNL
5361
MRPHT
5366
LNSTS
5371
MSKAY
5376
QSTFT
5381
GETNT
5386
PYSKQ
5391
FVHSK
5396
SSQYR
5401
RLRTE
5406
WKNNV
5411
YLARS
5416
RIQGL
5421
GLYAA
5426
KDLEK
5431
HTMVI
5436
EYIGT
5441
IIRNE
5446
VANRR
5451
EKIYE
5456
EQNRG
5461
IYMFR
5466
INNEH
5471
VIDAT
5476
LTGGP
5481
ARYIN
5486
HSCAP
5491
NCVAE
5496
VVTFD
5501
KEDKI
5506
IIISS
5511
RRIPK
5516
GEELT
5521
YDYQF
5526
DFEDD
5531
QHKIP
5536
CHCGA
5541
WNCRK
5546
WMN
5551
Mutation Information
DNA mutation:
None
Peptide Range:
4736 ~ 4744
Mut AA position:
4743 (8 in Wild Type peptide)
Alignment
Wild Type:
"ALSPVIPLI
|||||||.|
Mutant:
ALSPVIPHI"
reference
clinic trial
Checkpoint Blockade

None

ACT

N

Vaccination

N

Curative Effect

None

experiment
minimal_peptide

Y

Antigen Type

minigene mRNA

T-cell Source

PBMCs

APC Type

MoDCs

Assay

None