Immunogenicity 15842
Sample ID
patient1
Response
Positive
Tumor Type
Melanoma
Gene Symbol
ASTN1 (FPKM: 15214.8)
Transcript ID
None
HLA INFO
A*02:01
TCR INFO
TRAJAJ26
CDR3ACARYYGQNFVF
TRBVBV25-1
TRBDBD1
TRBJBJ1-1
TRAVAV38-2
CDR3BCASSERGMVEAFF
Full length protein sequence (1302 aa)
MALAG
1
LCALL
6
ACCWG
11
PAAVL
16
ATAAG
21
DVDPS
26
KELEC
31
KLKSI
36
TVSAL
41
PFLRE
46
NDLSI
51
MHSPS
56
ASEPK
61
LLFSV
66
RNDFP
71
GEMVV
76
VDDLE
81
NTELP
86
YFVLE
91
ISGNT
96
EDIPL
101
VRWRQ
106
QWLEN
111
GTLLF
116
HIHHQ
121
DGAPS
126
LPGQD
131
PTEEP
136
QHESA
141
EEELR
146
ILHIS
151
VMGGM
156
IALLL
161
SILCL
166
VMILY
171
TRRRW
176
CKRRR
181
VPQPQ
186
KSASA
191
EAANE
196
IHYIP
201
SVLIG
206
GHGRE
211
SLRNA
216
RVQGH
221
NSSGT
226
LSIRE
231
TPILD
236
GYEYD
241
ITDLR
246
HHLQR
251
ECMNG
256
GEDFA
261
SQVTR
266
TLDSL
271
QGCNE
276
KSGMD
281
LTPGS
286
DNAKL
291
SLMNK
296
YKDNI
301
IATSP
306
VDSNH
311
QQATL
316
LSHTS
321
SSQRK
326
RINNK
331
ARAGS
336
AFLNP
341
EGDSG
346
TEAEN
351
DPQLT
356
FYTDP
361
SRSRR
366
RSRVG
371
SPRSP
376
VNKTT
381
LTLIS
386
ITSCV
391
IGLVC
396
SSHVN
401
CPLVV
406
KITLH
411
VPEHL
416
IADGS
421
RFILL
426
EGSQL
431
DASDW
436
LNPAQ
441
VVLFS
446
QQNSS
451
GPWAM
456
DLCAR
461
RLLDP
466
CEHQC
471
DPETG
476
RREHR
481
AAGEC
486
LCYEG
491
YMKDP
496
VHKHL
501
CIRNE
506
WGTNQ
511
GPWPY
516
TIFQR
521
GFDLV
526
LGEQP
531
SDKIF
536
RFTYT
541
LGEGM
546
WLPLS
551
KSFVI
556
PPAEL
561
AINPS
566
AKCKT
571
DMTVM
576
EDAVE
581
VREEL
586
MTSSS
591
FDSLE
596
VLLDS
601
FGPVR
606
DCSKD
611
NGGCS
616
KNFRC
621
ISDRK
626
LDSTG
631
CVCPS
636
GLSPM
641
KDSSG
646
CYDRH
651
IGVDC
656
SDGFN
661
GGCEQ
666
LCLQQ
671
MAPFP
676
DDPTL
681
YNILM
686
FCGCI
691
EDYKL
696
GVDGR
701
SCQLI
706
TETCP
711
EGSDC
716
GESRE
721
LPMNQ
726
TLFGE
731
MFFGY
736
NNHSK
741
EVAAG
746
QVLKG
751
TFRQN
756
NFARG
761
LDQQL
766
PDGLV
771
VATVP
776
LENQC
781
LEEIS
786
EPTPD
791
PDFLT
796
GMVNF
801
SEVSG
806
YPVLQ
811
HWKVR
816
SVMYH
821
IKLNQ
826
VAISQ
831
ALSNA
836
LHSLD
841
GATSR
846
ADFVA
851
LLDQF
856
GNHYI
861
QEAIY
866
GFEES
871
CSIWY
876
PNKQV
881
QRRLW
886
LEYED
891
ISKGN
896
SPSDE
901
SEERE
906
RDPKV
911
LTFPE
916
YITSL
921
SDSGT
926
KHMAA
931
GVRME
936
CHSKG
941
RCPSS
946
CPLCH
951
VTSSP
956
DTPAE
961
PVLLE
966
VTKAA
971
PIYEL
976
VTNNQ
981
TQRLL
986
QEATM
991
SSLWC
996
SGTGD
1001
VIEDW
1006
CRCDS
1011
TAFGA
1016
DGLPT
1021
CAPLP
1026
QPVLR
1031
LSTVH
1036
EPSST
1041
LVVLE
1046
WEHSE
1051
PPIGV
1056
QIVDY
1061
LLRQE
1066
KVTDR
1071
MDHSK
1076
VETET
1081
VLSFV
1086
DDIIS
1091
GAKSP
1096
CAMPS
1101
QVPDK
1106
QLTTI
1111
SLIIR
1116
CLEPD
1121
TIYMF
1126
TLWGV
1131
DNTGR
1136
RSRPS
1141
DVIVK
1146
TPCPV
1151
VDDVK
1156
AQEIA
1161
DKIYN
1166
LFNGY
1171
TSGKE
1176
QQTAY
1181
NTLLD
1186
LGSPT
1191
LHRVL
1196
YHYNQ
1201
HYESF
1206
GEFTW
1211
RCEDE
1216
LGPRK
1221
AGLIL
1226
SQLGD
1231
LSSWC
1236
NGLLQ
1241
EPKIS
1246
LRRSS
1251
LKYLG
1256
CRYSE
1261
IKPYG
1266
LDWAE
1271
LSRDL
1276
RKTCE
1281
EQTLS
1286
IPYND
1291
YGDSK
1296
EI
1301
Mutation Information
DNA mutation:
None
Peptide Range:
1267 ~ 1276
Mut AA position:
None (2 in Wild Type peptide)
Alignment
Wild Type:
"KPYGLDWAEL
|.||||||||
Mutant:
KLYGLDWAEL"
Science, 2016
Targeting of cancer neoantigens with donor-derived T cell receptor repertoiresGene Name (from Reference) ASTN1
Checkpoint
Blockade
None
ACT
N
Vaccination
N
Curative
Effect
None
minimal_peptide
Y
Antigen
Type
minigene mRNA
T-cell
Source
PBMCs
APC
Type
MoDCs
Assay
None