Immunogenicity 15899
Sample ID
4136
Response
Positive
Tumor Type
Breast cancer
Gene Symbol
CADPS2
Transcript ID
None
HLA INFO
C*04:01
TCR INFO
CDR3AILRDVGNYQLI
TRBVBV28
TRAVAV26-2
CDR3BCASSLDREDEQYF
Full length protein sequence (1296 aa)
MLDPS
1
SSEEE
6
SDEGL
11
EEESR
16
DVLVA
21
AGSSQ
26
RAPPA
31
PTREG
36
RRDAP
41
GRAGG
46
GGAAR
51
SVSPS
56
PSVLS
61
EGRDE
66
PQRQL
71
DDEQE
76
RRIRL
81
QLYVF
86
VVRCI
91
AYPFN
96
AKQPT
101
DMARR
106
QQKLN
111
KQQLQ
116
LLKER
121
FQAFL
126
NGETQ
131
IVADE
136
AFCNA
141
VRSYY
146
EVFLK
151
SDRVA
156
RMVQS
161
GGCSA
166
NDFRE
171
VFKKN
176
IEKRV
181
RSLPE
186
IDGLS
191
KETVL
196
SSWIA
201
KYDAI
206
YRGEE
211
DLCKQ
216
PNRMA
221
LSAVS
226
ELILS
231
KEQLY
236
EMFQQ
241
ILGIK
246
KLEHQ
251
LLYNA
256
CQLDN
261
ADEQA
266
AQIRR
271
ELDGR
276
LQLAD
281
KMAKE
286
RKFPK
291
FIAKD
296
MENMY
301
IEELR
306
SSVNL
311
LMANL
316
ESLPV
321
SKGGP
326
EFKLQ
331
KLKRS
336
QNSAF
341
LDIGD
346
ENEIQ
351
LSKSD
356
VVLSF
361
TLEIV
366
IMEVQ
371
GLKSV
376
APNRI
381
VYCTM
386
EVEGE
391
KLQTD
396
QAEAS
401
RPQWG
406
TQGDF
411
TTTHP
416
RPVVK
421
VKLFT
426
ESTGV
431
LALED
436
KELGR
441
VILYP
446
TSNSS
451
KSAEL
456
HRMVV
461
PKNSQ
466
DSDLK
471
IKLAV
476
RMDKP
481
AHMKH
486
SGYLY
491
ALGQK
496
VWKRW
501
KKRYF
506
VLVQV
511
SQYTF
516
AMCSY
521
REKKS
526
EPQEL
531
MQLEG
536
YTVDY
541
TDPHP
546
GLQGG
551
CMFFN
556
AVKEG
561
DTVIF
566
ASDDE
571
QDRIL
576
WVQAM
581
YRATG
586
QSYKP
591
VPAIQ
596
TQKLN
601
PKGGT
606
LHADA
611
QLSGK
616
DADRF
621
QKHGM
626
DEFIS
631
ANPCK
636
LDHAF
641
LFRIL
646
QRQTL
651
DHRLN
656
DSYSC
661
LGWFS
666
PGQVF
671
VLDEY
676
CARYG
681
VRGCH
686
RHLCY
691
LAELM
696
EHSEN
701
GAVID
706
PTLLH
711
YSFAF
716
CASHV
721
HGNRP
726
DGIGT
731
VSVEE
736
KERFE
741
EIKER
746
LSSLL
751
ENQIS
756
HFRYC
761
FPFGR
766
PEGAL
771
KATLS
776
LLERV
781
LMKDI
786
ATPIP
791
AEEVK
796
KVVRK
801
CLEKA
806
ALINY
811
TRLTE
816
YAKIE
821
ETMNQ
826
ASPAR
831
KLEEI
836
LHLAE
841
LCIEV
846
LQQNE
851
EHHAE
856
GREAF
861
AWWPD
866
LLAEH
871
AEKFW
876
ALFTV
881
DMDTA
886
LEAQP
891
QDSWD
896
SFPLF
901
QLLNN
906
FLRND
911
TLLCN
916
GKFHK
921
HLQEI
926
FVPLV
931
VRYVD
936
LMESS
941
IAQSI
946
HRGFE
951
QETWQ
956
PVKNI
961
ANSLP
966
NVALP
971
KVPSL
976
PLNLP
981
QIPNI
986
STASW
991
MPSLY
996
ESTNG
1001
SATSE
1006
DLFWK
1011
LDALQ
1016
MFVFD
1021
LHWPE
1026
QEFAH
1031
HLEQR
1036
LKLMA
1041
SDMLE
1046
ACVKR
1051
TRTAF
1056
ELKLQ
1061
KASKT
1066
TDLRI
1071
PASVC
1076
TMFNV
1081
LVDAK
1086
KQSTK
1091
LCALD
1096
GGQEQ
1101
QYHSK
1106
IDDLI
1111
DNSVK
1116
EIISL
1121
LVSKF
1126
VSVLE
1131
GVLSK
1136
LSRYD
1141
EGTFF
1146
SSILS
1151
FTVKA
1156
AAKYV
1161
DVPKP
1166
GMDLA
1171
DTYIM
1176
FVRQN
1181
QDILR
1186
EKVNE
1191
EMYIE
1196
KLFDQ
1201
WYSSS
1206
MKVIC
1211
VWLTD
1216
RLDLQ
1221
LHIYQ
1226
LKTLI
1231
KIVKK
1236
TYRDF
1241
RLQGV
1246
LEGTL
1251
NSKTY
1256
DTVHR
1261
RLTVE
1266
EATAS
1271
VSEGG
1276
GLQGI
1281
TMKDS
1286
DEEEE
1291
G
1296
Mutation Information
DNA mutation:
None
Peptide Range:
1254 ~ 1262
Mut AA position:
1266 (13 in Wild Type peptide)
Alignment
Wild Type:
"TLNSKTYDTVHRRLTVEEATASVSE
|||||||.|
Mutant:
-----TYDTVHRHL-----------"
Nat Med, 2018
Immune recognition of somatic mutations leading to complete durable regression in metastatic breast cancerGene Name (from Reference) CADPS2
Checkpoint
Blockade
None
ACT
N
Vaccination
N
Curative
Effect
N
minimal_peptide
Y
Antigen
Type
peptide
T-cell
Source
TILs
APC
Type
APCs
Assay
ELISPOT