Immunogenicity 1634

summary
Sample ID
3942
Response
Negative
Tumor Type
Rectal cancer
Gene Symbol
ABCC12
Transcript ID
ENST00000532494
HLA INFO
DQA*02:01 / DQB*02:02
TCR INFO

No TCR info found!

T cell Tumor cell { DQA*02:01 DQB*02:02
sequence
Full length protein sequence (1009 aa)
MVGEG
1
PYLIS
6
DLDQR
11
GRRRS
16
FAERY
21
DPSLK
26
TMIPV
31
RPCAR
36
LAPNP
41
VDDAG
46
LLSFA
51
TFSWL
56
TPVMV
61
KGYRQ
66
RLTVD
71
TLPPL
76
STYDS
81
SDTNA
86
KRFRV
91
LWDEE
96
VARVG
101
PEKAS
106
LSHVV
111
WKFQR
116
TRVLM
121
DIVAN
126
ILCII
131
MAAIG
136
PTVLI
141
HQILQ
146
QTERT
151
SGKVW
156
VGIGL
161
CIALF
166
ATEFT
171
KVFFW
176
ALAWA
181
INYRT
186
AIRLK
191
VALST
196
LVFEN
201
LVSFK
206
TLTHI
211
SVGEV
216
LNILS
221
SDSYS
226
LFEAA
231
LFCPL
236
PATIP
241
ILMVF
246
CAAYA
251
FFILG
256
PTALI
261
GISVY
266
VIFIP
271
VQMFM
276
AKLNS
281
AFRRS
286
AILVT
291
DKRVQ
296
TMNEF
301
LTCIR
306
LIKMY
311
AWEKS
316
FTNTI
321
QDIRR
326
RERKL
331
LEKAG
336
FVQSG
341
NSALA
346
PIVST
351
IAIVL
356
TLSCH
361
ILLRR
366
KLTAP
371
VAFSV
376
IAMFN
381
VMKFS
386
IAILP
391
FSIKA
396
MAEAN
401
VSLRR
406
MKKIL
411
IDKSP
416
PSYIT
421
QPEDP
426
DTVLL
431
LANAT
436
LTWEH
441
EASRK
446
STPKK
451
LQNQK
456
RHLCK
461
KQRSE
466
AYSER
471
SPPAK
476
GATGP
481
EEQSD
486
SLKSV
491
LHSIS
496
FVVRK
501
GKILG
506
ICGNV
511
GSGKS
516
SLLAA
521
LLGQM
526
QLQKG
531
VVAVN
536
GTLAY
541
VSQQA
546
WIFHG
551
NVREN
556
ILFGE
561
KYDHQ
566
RYQHT
571
VRVCG
576
LQKDL
581
SNLPY
586
GDLTE
591
IGERG
596
LNLSG
601
GQRQR
606
ISLAR
611
AVYSD
616
RQLYL
621
LDDPL
626
SAVDA
631
HVGKH
636
VFEEC
641
IKKTL
646
RGKTV
651
VLVTH
656
QLQFL
661
ESCDE
666
VILLE
671
DGEIC
676
EKGTH
681
KELME
686
ERGRY
691
AKLIH
696
NLRGL
701
QFKDP
706
EHLYN
711
AAMVE
716
AFKES
721
PAERE
726
EDAVL
731
APGNE
736
KDEGK
741
ESETG
746
SEFVD
751
TKVPE
756
HQLIQ
761
TESPQ
766
EGTVT
771
WKTYH
776
TYIKA
781
SGGYL
786
LSLFT
791
VFLFL
796
LMIGS
801
AAFSN
806
WWLGL
811
WLDKG
816
SRMTC
821
GPQGN
826
RTMCE
831
VGAVL
836
ADIGQ
841
HVYQW
846
VYTAS
851
MVFML
856
VFGVT
861
KGFVF
866
TKTTL
871
MASSS
876
LHDTV
881
FDKIL
886
KSPMS
891
FFDTT
896
PTGRL
901
MNRFS
906
KDMDE
911
LDVRL
916
PFHAE
921
NFLQQ
926
FFMVV
931
FILVI
936
LAAVF
941
PAVLL
946
VVASL
951
AVGFF
956
ILLRI
961
FHRGV
966
QELKK
971
VENVS
976
RSPWF
981
THITS
986
SMQGL
991
GIIHA
996
YGKKE
1001
SCIT
1006
Mutation Information
DNA mutation:
None
Peptide Range:
218 ~ 242
Mut AA position:
230 (13 in Wild Type peptide)
Alignment
Wild Type:
"GEVLNILSSDSYSLFEAALFCPLPA
||||||||||||.||||||||||||
Mutant:
GEVLNILSSDSYCLFEAALFCPLPA"
reference

Science, 2015

Immunogenicity of somatic mutations in human gastrointestinal cancers

Gene Name (from Reference) ABCC12

clinic trial
Checkpoint Blockade

None

ACT

None

Vaccination

None

Curative Effect

None

experiment
minimal_peptide

None

Antigen Type

TMG RNA

T-cell Source

TILs

APC Type

autologous DCs

Assay

IFNg ELISPOT assay