Immunogenicity 1782
Sample ID
3942
Response
Negative
Tumor Type
Rectal cancer
Gene Symbol
RYR2
Transcript ID
ENST00000542537
HLA INFO
B*14:02
TCR INFO
No TCR info found!
Full length protein sequence (4951 aa)
DDEVV
1
LQCTA
6
TIHKE
11
QQKLC
16
LAAEG
21
FGNRL
26
CFLES
31
TSNSK
36
NVPPD
41
LSICT
46
FVLEQ
51
SLSVR
56
ALQEM
61
LANTV
66
EKSEG
71
QVDVE
76
KWKFM
81
MKTAQ
86
GGGHR
91
TLLYG
96
HAILL
101
RHSYS
106
GMYLC
111
CLSTS
116
RSSTD
121
KLAFD
126
VGLQE
131
DTTGE
136
ACWWT
141
IHPAS
146
KQRSE
151
GEKVR
156
VGDDL
161
ILVSV
166
SSERY
171
LHLSY
176
GNGSL
181
HVDAA
186
FQQTL
191
WSVAP
196
ISSGS
201
EAAQG
206
YLIGG
211
DVLRL
216
LHGHM
221
DECLT
226
VPSGE
231
HGEEQ
236
RRTVH
241
YEGGA
246
VSVHA
251
RSLWR
256
LETLR
261
VAWSG
266
SHIRW
271
GQPFR
276
LRHVT
281
TGKYL
286
SLMED
291
KNLLL
296
MDKEK
301
ADVKS
306
TAFTF
311
RSSKE
316
KLDVG
321
VRKEV
326
DGMGT
331
SEIKY
336
GDSVC
341
YIQHV
346
DTGLW
351
LTYQS
356
VDVKS
361
VRMGS
366
IQRKA
371
IMHHE
376
GHMDD
381
GISLS
386
RSQHE
391
ESRTA
396
RVIRS
401
TVFLF
406
NRFIR
411
GLDAL
416
SKKAK
421
ASTVD
426
LPIES
431
VSLSL
436
QDLIG
441
YFHPP
446
DEHLE
451
HEDKQ
456
NRLRA
461
LKNRQ
466
NLFQE
471
EGMIN
476
LVLEC
481
IDRLH
486
VYSSA
491
AHFAD
496
VAGRE
501
AGESW
506
KSILN
511
SLYEL
516
LAALI
521
RGNRK
526
NCAQF
531
SGSLD
536
WLISR
541
LERLE
546
ASSGI
551
LEVLH
556
CVLVE
561
SPEAL
566
NIIKE
571
GHIKS
576
IISLL
581
DKHGR
586
NHKVL
591
DVLCS
596
LCVCH
601
GVAVR
606
SNQHL
611
ICDNL
616
LPGRD
621
LLLQT
626
RLVNH
631
VSSMR
636
PNIFL
641
GVSEG
646
SAQYK
651
KWYYE
656
LMVDH
661
TEPFV
666
TAEAT
671
HLRVG
676
WASTE
681
GYSPY
686
PGGGE
691
EWGGN
696
GVGDD
701
LFSYG
706
FDGLH
711
LWSGC
716
IARTV
721
SSPNQ
726
HLLRT
731
DDVIS
736
CCLDL
741
SAPSI
746
SFRIN
751
GQPVQ
756
GMFEN
761
FNIDG
766
LFFPV
771
VSFSA
776
GIKVR
781
FLLGG
786
RHGEF
791
KFLPP
796
PGYAP
801
CYEAV
806
LPKEK
811
LKVEH
816
SREYK
821
QERTY
826
TRDLL
831
GPTVS
836
LTQAA
841
FTPIP
846
VDTSQ
851
IVLPP
856
HLERI
861
REKLA
866
ENIHE
871
LWVMN
876
KIELG
881
WQYGP
886
VRDDN
891
KRQHP
896
CLVEF
901
SKLPE
906
QERNY
911
NLQMS
916
LETLK
921
TLLAL
926
GCHVG
931
ISDEH
936
AEDKV
941
KKMKL
946
PKNYQ
951
LTSGY
956
KPAPM
961
DLSFI
966
KLTPS
971
QEAMV
976
DKLAE
981
NAHNV
986
WARDR
991
IRQGW
996
TYGIQ
1001
QDVKN
1006
RRNPR
1011
LVPYT
1016
LLDDR
1021
TKKSN
1026
KDSLR
1031
EAVRT
1036
LLGYG
1041
YNLEA
1046
PDQDH
1051
AARAE
1056
VCSGT
1061
GERFR
1066
IFRAE
1071
KTYAV
1076
KAGRW
1081
YFEFE
1086
TVTAG
1091
DMRVG
1096
WSRPG
1101
CQPDQ
1106
ELGSD
1111
ERAFA
1116
FDGFK
1121
AQRWH
1126
QGNEH
1131
YGRSW
1136
QAGDV
1141
VGCMV
1146
DMNEH
1151
TMMFT
1156
LNGEI
1161
LLDDS
1166
GSELA
1171
FKDFD
1176
VGDGF
1181
IPVCS
1186
LGVAQ
1191
VGRMN
1196
FGKDV
1201
STLKY
1206
FTICG
1211
LQEGY
1216
EPFAV
1221
NTNRD
1226
ITMWL
1231
SKRLP
1236
QFLQV
1241
PSNHE
1246
HIEVT
1251
RIDGT
1256
IDSSP
1261
CLKVT
1266
QKSFG
1271
SQNSN
1276
TDIMF
1281
YRLSM
1286
PIECA
1291
EVFSK
1296
TVAGG
1301
LPGAG
1306
LFGPK
1311
NDLED
1316
YDADS
1321
DFEVL
1326
MKTAH
1331
GHLVP
1336
DRVDK
1341
DKEAT
1346
KPEFN
1351
NHKDY
1356
AQEKP
1361
SRLKQ
1366
RFLLR
1371
RTKPD
1376
YSTSH
1381
SARLT
1386
EDVLA
1391
DDRDD
1396
YDFLM
1401
QTSTY
1406
YYSVR
1411
IFPGQ
1416
EPANV
1421
WVGWI
1426
TSDFH
1431
QYDTG
1436
FDLDR
1441
VRTVT
1446
VTLGD
1451
EKGKV
1456
HESIK
1461
RSNCY
1466
MVCAG
1471
ESMSP
1476
GQGRN
1481
NNGLE
1486
IGCVV
1491
DAASG
1496
LLTFI
1501
ANGKE
1506
LSTYY
1511
QVEPS
1516
TKLFP
1521
AVFAQ
1526
ATSPN
1531
VFQFE
1536
LGRIK
1541
NVMPL
1546
SAGLF
1551
KSEHK
1556
NPVPQ
1561
CPPRL
1566
HVQFL
1571
SHVLW
1576
SRMPN
1581
QFLKV
1586
DVSRI
1591
SERQG
1596
WLVQC
1601
LDPLQ
1606
FMSLH
1611
IPEEN
1616
RSVDI
1621
LELTE
1626
QEELL
1631
KFHYH
1636
TLRLY
1641
SAVCA
1646
LGNHR
1651
VAHAL
1656
CSHVD
1661
EPQLL
1666
YAIEN
1671
KYMPG
1676
LLRAG
1681
YYDLL
1686
IDIHL
1691
SSYAT
1696
ARLMM
1701
NNEYI
1706
VPMTE
1711
ETKSI
1716
TLFPD
1721
ENKKH
1726
GLPGI
1731
GLSTS
1736
LRPRM
1741
QFSSP
1746
SFVSI
1751
SNECY
1756
QYSPE
1761
FPLDI
1766
LKSKT
1771
IQMLT
1776
EAVKE
1781
GSLHA
1786
RDPVG
1791
GTTEF
1796
LFVPL
1801
IKLFY
1806
TLLIM
1811
GIFHN
1816
EDLKH
1821
ILQLI
1826
EPSVF
1831
KEAAT
1836
PEEES
1841
DTLEK
1846
ELSVD
1851
DAKLQ
1856
GAGEE
1861
EAKGG
1866
KRPKE
1871
GLLQM
1876
KLPEP
1881
VKLQM
1886
CLLLQ
1891
YLCDC
1896
QVRHR
1901
IEAIV
1906
AFSDD
1911
FVAKL
1916
QDNQR
1921
FRYNE
1926
VMQAL
1931
NMSAA
1936
LTARK
1941
TKEFR
1946
SPPQE
1951
QINML
1956
LNFKD
1961
DKSEC
1966
PCPEE
1971
IRDQL
1976
LDFHE
1981
DLMTH
1986
CGIEL
1991
DEDGS
1996
LDGNS
2001
DLTIR
2006
GRLLS
2011
LVEKV
2016
TYLKK
2021
KQAEK
2026
PVESD
2031
SKKSS
2036
TLQQL
2041
ISETM
2046
VRWAQ
2051
ESVIE
2056
DPELV
2061
RAMFV
2066
LLHRQ
2071
YDGIG
2076
GLVRA
2081
LPKTY
2086
TINGV
2091
SVEDT
2096
INLLA
2101
SLGQI
2106
RSLLS
2111
VRMGK
2116
EEEKL
2121
MIRGL
2126
GDIMN
2131
NKVFY
2136
QHPNL
2141
MRALG
2146
MHETV
2151
MEVMV
2156
NVLGG
2161
GESKE
2166
ITFPK
2171
MVANC
2176
CRFLC
2181
YFCRI
2186
SRQNQ
2191
KAMFD
2196
HLSYL
2201
LENSS
2206
VGLAS
2211
PAMRG
2216
STPLD
2221
VAAAS
2226
VMDNN
2231
ELALA
2236
LREPD
2241
LEKVV
2246
RYLAG
2251
CGLQS
2256
CQMLV
2261
SKGYP
2266
DIGWN
2271
PVEGE
2276
RYLDF
2281
LRFAV
2286
FCNGE
2291
SVEEN
2296
ANVVV
2301
RLLIR
2306
RPECF
2311
GPALR
2316
GEGGN
2321
GLLAA
2326
MEEAI
2331
KIAED
2336
PSRDG
2341
PSPNS
2346
GSSKT
2351
LDTEE
2356
EEDDT
2361
IHMGN
2366
AIMTF
2371
YSALI
2376
DLLGR
2381
CAPEM
2386
HLIHA
2391
GKGEA
2396
IRIRS
2401
ILRSL
2406
IPLGD
2411
LVGVI
2416
SIAFQ
2421
MPTIA
2426
KDGNV
2431
VEPDM
2436
SAGFC
2441
PDHKA
2446
AMVLF
2451
LDRVY
2456
GIEVQ
2461
DFLLH
2466
LLEVG
2471
FLPDL
2476
RAAAS
2481
LDTAA
2486
LSATD
2491
MALAL
2496
NRYLC
2501
TAVLP
2506
LLTRC
2511
APLFA
2516
GTEHH
2521
ASLID
2526
SLLHT
2531
VYRLS
2536
KGCSL
2541
TKAQR
2546
DSIEV
2551
CLLSI
2556
CGQLR
2561
PSMMQ
2566
HLLRR
2571
LVFDV
2576
PLLNE
2581
HAKMP
2586
LKLLT
2591
NHYER
2596
CWKYY
2601
CLPGG
2606
WGNFG
2611
AASEE
2616
ELHLS
2621
RKLFW
2626
GIFDA
2631
LSQKK
2636
YEQEL
2641
FKLAL
2646
PCLSA
2651
VAGAL
2656
PPDYM
2661
ESNYV
2666
SMMEK
2671
QSSMD
2676
SEGNF
2681
NPQPV
2686
DTSNI
2691
TIPEK
2696
LEYFI
2701
NKYAE
2706
HSHDK
2711
WSMDK
2716
LANGW
2721
IYGEI
2726
YSDSS
2731
KVQPL
2736
MKPYK
2741
LLSEK
2746
EKEIY
2751
RWPIK
2756
ESLKT
2761
MLAWG
2766
WRIER
2771
TREGD
2776
SMALY
2781
NRTRR
2786
ISQTS
2791
QVSVD
2796
AAHGY
2801
SPRAI
2806
DMSNV
2811
TLSRD
2816
LHAMA
2821
EMMAE
2826
NYHNI
2831
WAKKK
2836
KMELE
2841
SKGGG
2846
NHPLL
2851
VPYDT
2856
LTAKE
2861
KAKDR
2866
EKAQD
2871
ILKFL
2876
QINGY
2881
AVSRG
2886
FKDLE
2891
LDTPS
2896
IEKRF
2901
AYSFL
2906
QQLIR
2911
YVDEA
2916
HQYIL
2921
EFDGG
2926
SRGKG
2931
EHFPY
2936
EQEIK
2941
FFAKV
2946
VLPLI
2951
DQYFK
2956
NHRLY
2961
FLSAA
2966
SRPLC
2971
SGGHA
2976
SNKEK
2981
EMVTS
2986
LFCKL
2991
GVLVR
2996
HRISL
3001
FGNDA
3006
TSIVN
3011
CLHIL
3016
GQTLD
3021
ARTVM
3026
KTGLE
3031
SVKSA
3036
LRAFL
3041
DNAAE
3046
DLEKT
3051
MENLK
3056
QGQFT
3061
HTRNQ
3066
PKGVT
3071
QIINY
3076
TTVAL
3081
LPMLS
3086
SLFEH
3091
IGQHQ
3096
FGEDL
3101
ILEDV
3106
QVSCY
3111
RILTS
3116
LYALG
3121
TSKSI
3126
YVERQ
3131
RSALG
3136
ECLAA
3141
FAGAF
3146
PVAFL
3151
ETHLD
3156
KHNIY
3161
SIYNT
3166
KSSRE
3171
RAALS
3176
LPTNV
3181
EDVCP
3186
NIPSL
3191
EKLME
3196
EIVEL
3201
AESGI
3206
RYTQM
3211
PHVME
3216
VILPM
3221
LCSYM
3226
SRWWE
3231
HGPEN
3236
NPERA
3241
EMCCT
3246
ALNSE
3251
HMNTL
3256
LGNIL
3261
KIIYN
3266
NLGID
3271
EGAWM
3276
KRLAV
3281
FSQPI
3286
INKVK
3291
PQLLK
3296
THFLP
3301
LMEKL
3306
KKKAA
3311
TVVSE
3316
EDHLK
3321
AEARG
3326
DMSEA
3331
ELLIL
3336
DEFTT
3341
LARDL
3346
YAFYP
3351
LLIRF
3356
VDYNR
3361
AKWLK
3366
EPNPE
3371
AEELF
3376
RMVAE
3381
VFIYW
3386
SKSHN
3391
FKREE
3396
QNFVV
3401
QNEIN
3406
NMSFL
3411
ITDTK
3416
SKMSK
3421
AAVSD
3426
QERKK
3431
MKRKG
3436
DRYSM
3441
QTSLI
3446
VAALK
3451
RLLPI
3456
GLNIC
3461
APGDQ
3466
ELIAL
3471
AKNRF
3476
SLKDT
3481
EDEVR
3486
DIIRS
3491
NIHLQ
3496
GKLED
3501
PAIRW
3506
QMALY
3511
KDLPN
3516
RTDDT
3521
SDPEK
3526
TVERV
3531
LDIAN
3536
VLFHL
3541
EQKSK
3546
RVGRR
3551
HYCLV
3556
EHPQR
3561
SKKAV
3566
WHKLL
3571
SKQRK
3576
RAVVA
3581
CFRMA
3586
PLYNL
3591
PRHRA
3596
VNLFL
3601
QGYEK
3606
SWIET
3611
EEHYF
3616
EDKLI
3621
EDLAK
3626
PGAEP
3631
PEEDE
3636
GTKRV
3641
DPLHQ
3646
LILLF
3651
SRTAL
3656
TEKCK
3661
LEEDF
3666
LYMAY
3671
ADIMA
3676
KSCHD
3681
EEDDD
3686
GEEEV
3691
KSFEE
3696
KEMEK
3701
QKLLY
3706
QQARL
3711
HDRGA
3716
AEMVL
3721
QTISA
3726
SKGET
3731
GPMVA
3736
ATLKL
3741
GIAIL
3746
NGGNS
3751
TVQQK
3756
MLDYL
3761
KEKKD
3766
VGFFQ
3771
SLAGL
3776
MQSCS
3781
VLDLN
3786
AFERQ
3791
NKAEG
3796
LGMVT
3801
EEGSG
3806
EKVLQ
3811
DDEFT
3816
CDLFR
3821
FLQLL
3826
CEGHN
3831
SDFQN
3836
YLRTQ
3841
TGNNT
3846
TVNII
3851
ISTVD
3856
YLLRV
3861
QESIS
3866
DFYWY
3871
YSGKD
3876
VIDEQ
3881
GQRNF
3886
SKAIQ
3891
VAKQV
3896
FNTLT
3901
EYIQG
3906
PCTGN
3911
QQSLA
3916
HSRLW
3921
DAVVG
3926
FLHVF
3931
AHMQM
3936
KLSQD
3941
SSQIE
3946
LLKEL
3951
MDLQK
3956
DMVVM
3961
LLSML
3966
EGNVV
3971
NGTIG
3976
KQMVD
3981
MLVES
3986
SNNVE
3991
MILKF
3996
FDMFL
4001
KLKDL
4006
TSSDT
4011
FKEYD
4016
PDGKG
4021
VISKR
4026
DFHKA
4031
MESHK
4036
HYTQS
4041
ETEFL
4046
LSCAE
4051
TDENE
4056
TLDYE
4061
EFVKR
4066
FHEPA
4071
KDIGF
4076
NVAVL
4081
LTNLS
4086
EHMPN
4091
DTRLQ
4096
TFLEL
4101
AESVL
4106
NYFQP
4111
FLGRI
4116
EIMGS
4121
AKRIE
4126
RVYFE
4131
ISESS
4136
RTQWE
4141
KPQVK
4146
ESKRQ
4151
FIFDV
4156
VNEGG
4161
EKEKM
4166
ELFVN
4171
FCEDT
4176
IFEMQ
4181
LAAQI
4186
SESDL
4191
NERSA
4196
NKEES
4201
EKERP
4206
EEQGP
4211
RMAFF
4216
SILTV
4221
RSALF
4226
ALRYN
4231
ILTLM
4236
RMLSL
4241
KSLKK
4246
QMKKV
4251
KKMTV
4256
KDMVT
4261
AFFSS
4266
YWSIF
4271
MTLLH
4276
FVASV
4281
FRGFF
4286
RIICS
4291
LLLGG
4296
SLVEG
4301
AKKIK
4306
VAELL
4311
ANMPD
4316
PTQDE
4321
VRGDG
4326
EEGER
4331
KPLEA
4336
ALPSE
4341
DLTDL
4346
KELTE
4351
ESDLL
4356
SDIFG
4361
LDLKR
4366
EGGQY
4371
KLIPH
4376
NPNAG
4381
LSDLM
4386
SNPVP
4391
MPEVQ
4396
EKFQE
4401
QKAKE
4406
EEKEE
4411
KEETK
4416
SEPEK
4421
AEGED
4426
GEKEE
4431
KAKED
4436
KGKQK
4441
LRQLH
4446
THRYG
4451
EPEVP
4456
ESAFW
4461
KKIIA
4466
YQQKL
4471
LNYFA
4476
RNFYN
4481
MRMLA
4486
LFVAF
4491
AINFI
4496
LLFYK
4501
VSTSS
4506
VVEGK
4511
ELPTR
4516
SSSEN
4521
AKVTS
4526
LDSSS
4531
HRIIA
4536
VHYVL
4541
EESSG
4546
YMEPT
4551
LRILA
4556
ILHTV
4561
ISFFC
4566
IIGYY
4571
CLKVP
4576
LVIFK
4581
REKEV
4586
ARKLE
4591
FDGLY
4596
ITEQP
4601
SEDDI
4606
KGQWD
4611
RLVIN
4616
TQSFP
4621
NNYWD
4626
KFVKR
4631
KVMDK
4636
YGEFY
4641
GRDRI
4646
SELLG
4651
MDKAA
4656
LDFSD
4661
AREKK
4666
KPKKD
4671
SSLSA
4676
VLNSI
4681
DVKYQ
4686
MWKLG
4691
VVFTD
4696
NSFLY
4701
LAWYM
4706
TMSVL
4711
GHYNN
4716
FFFAA
4721
HLLDI
4726
AMGFK
4731
TLRTI
4736
LSSVT
4741
HNGKQ
4746
LVLTV
4751
GLLAV
4756
VVYLY
4761
TVVAF
4766
NFFRK
4771
FYNKS
4776
EDGDT
4781
PDMKC
4786
DDMLT
4791
CYMFH
4796
MYVGV
4801
RAGGG
4806
IGDEI
4811
EDPAG
4816
DEYEI
4821
YRIIF
4826
DITFF
4831
FFVIV
4836
ILLAI
4841
IQGLI
4846
IDAFG
4851
ELRDQ
4856
QEQVK
4861
EDMET
4866
KCFIC
4871
GIGND
4876
YFDTV
4881
PHGFE
4886
THTLQ
4891
EHNLA
4896
NYLFF
4901
LMYLI
4906
NKDET
4911
EHTGQ
4916
ESYVW
4921
KMYQE
4926
RCWEF
4931
FPAGD
4936
CFRKQ
4941
YEDQL
4946
N
4951
Mutation Information
DNA mutation:
None
Peptide Range:
4041 ~ 4065
Mut AA position:
4053 (13 in Wild Type peptide)
Alignment
Wild Type:
"HYTQSETEFLLSCAETDENETLDYE
||||||||||||.||||||||||||
Mutant:
HYTQSETEFLLSSAETDENETLDYE"
Science, 2015
Immunogenicity of somatic mutations in human gastrointestinal cancersGene Name (from Reference) RYR2
Checkpoint
Blockade
None
ACT
None
Vaccination
None
Curative
Effect
None
minimal_peptide
None
Antigen
Type
TMG RNA
T-cell
Source
TILs
APC
Type
autologous DCs
Assay
IFNg ELISPOT assay