Immunogenicity 2061
Sample ID
3971
Response
Negative
Tumor Type
Colon cancer
Gene Symbol
NOTCH3
Transcript ID
ENST00000263388
HLA INFO
DQA*05:01 / DQB*06:03
TCR INFO
No TCR info found!
Full length protein sequence (2321 aa)
MGPGA
1
RGRRR
6
RRRPM
11
SPPPP
16
PPPVR
21
ALPLL
26
LLLAG
31
PGAAA
36
PPCLD
41
GSPCA
46
NGGRC
51
TQLPS
56
REAAC
61
LCPPG
66
WVGER
71
CQLED
76
PCHSG
81
PCAGR
86
GVCQS
91
SVVAG
96
TARFS
101
CRCPR
106
GFRGP
111
DCSLP
116
DPCLS
121
SPCAH
126
GARCS
131
VGPDG
136
RFLCS
141
CPPGY
146
QGRSC
151
RSDVD
156
ECRVG
161
EPCRH
166
GGTCL
171
NTPGS
176
FRCQC
181
PAGYT
186
GPLCE
191
NPAVP
196
CAPSP
201
CRNGG
206
TCRQS
211
GDLTY
216
DCACL
221
PGFEG
226
QNCEV
231
NVDDC
236
PGHRC
241
LNGGT
246
CVDGV
251
NTYNC
256
QCPPE
261
WTGQF
266
CTEDV
271
DECQL
276
QPNAC
281
HNGGT
286
CFNTL
291
GGHSC
296
VCVNG
301
WTGES
306
CSQNI
311
DDCAT
316
AVCFH
321
GATCH
326
DRVAS
331
FYCAC
336
PMGKT
341
GLLCH
346
LDDAC
351
VSNPC
356
HEDAI
361
CDTNP
366
VNGRA
371
ICTCP
376
PGFTG
381
GACDQ
386
DVDEC
391
SIGAN
396
PCEHL
401
GRCVN
406
TQGSF
411
LCQCG
416
RGYTG
421
PRCET
426
DVNEC
431
LSGPC
436
RNQAT
441
CLDRI
446
GQFTC
451
ICMAG
456
FTGTY
461
CEVDI
466
DECQS
471
SPCVN
476
GGVCK
481
DRVNG
486
FSCTC
491
PSGFS
496
GSTCQ
501
LDVDE
506
CASTP
511
CRNGA
516
KCVDQ
521
PDGYE
526
CRCAE
531
GFEGT
536
LCDRN
541
VDDCS
546
PDPCH
551
HGRCV
556
DGIAS
561
FSCAC
566
APGYT
571
GTRCE
576
SQVDE
581
CRSQP
586
CRHGG
591
KCLDL
596
VDKYL
601
CRCPS
606
GTTGV
611
NCEVN
616
IDDCA
621
SNPCT
626
FGVCR
631
DGINR
636
YDCVC
641
QPGFT
646
GPLCN
651
VEINE
656
CASSP
661
CGEGG
666
SCVDG
671
ENGFR
676
CLCPP
681
GSLPP
686
LCLPP
691
SHPCA
696
HEPCS
701
HGICY
706
DAPGG
711
FRCVC
716
EPGWS
721
GPRCS
726
QSLAR
731
DACES
736
QPCRA
741
GGTCS
746
SDGMG
751
FHCTC
756
PPGVQ
761
GRQCE
766
LLSPC
771
TPNPC
776
EHGGR
781
CESAP
786
GQLPV
791
CSCPQ
796
GWQGP
801
RCQQD
806
VDECA
811
GPAPC
816
GPHGI
821
CTNLA
826
GSFSC
831
TCHGG
836
YTGPS
841
CDQDI
846
NDCDP
851
NPCLN
856
GGSCQ
861
DGVGS
866
FSCSC
871
LPGFA
876
GPRCA
881
RDVDE
886
CLSNP
891
CGPGT
896
CTDHV
901
ASFTC
906
TCPPG
911
YGGFH
916
CEQDL
921
PDCSP
926
SSCFN
931
GGTCV
936
DGVNS
941
FSCLC
946
RPGYT
951
GAHCQ
956
HEADP
961
CLSRP
966
CLHGG
971
VCSAA
976
HPGFR
981
CTCLE
986
SFTGP
991
QCQTL
996
VDWCS
1001
RQPCQ
1006
NGGRC
1011
VQTGA
1016
YCLCP
1021
PGWSG
1026
RLCDI
1031
RSLPC
1036
REAAA
1041
QIGVR
1046
LEQLC
1051
QAGGQ
1056
CVDED
1061
SSHYC
1066
VCPEG
1071
RTGSH
1076
CEQEV
1081
DPCLA
1086
QPCQH
1091
GGTCR
1096
GYMGG
1101
YMCEC
1106
LPGYN
1111
GDNCE
1116
DDVDE
1121
CASQP
1126
CQHGG
1131
SCIDL
1136
VARYL
1141
CSCPP
1146
GTLGV
1151
LCEIN
1156
EDDCG
1161
PGPPL
1166
DSGPR
1171
CLHNG
1176
TCVDL
1181
VGGFR
1186
CTCPP
1191
GYTGL
1196
RCEAD
1201
INECR
1206
SGACH
1211
AAHTR
1216
DCLQD
1221
PGGGF
1226
RCLCH
1231
AGFSG
1236
PRCQT
1241
VLSPC
1246
ESQPC
1251
QHGGQ
1256
CRPSP
1261
GPGGG
1266
LTFTC
1271
HCAQP
1276
FWGPR
1281
CERVA
1286
RSCRE
1291
LQCPV
1296
GVPCQ
1301
QTPRG
1306
PRCAC
1311
PPGLS
1316
GPSCR
1321
SFPGS
1326
PPGAS
1331
NASCA
1336
AAPCL
1341
HGGSC
1346
RPAPL
1351
APFFR
1356
CACAQ
1361
GWTGP
1366
RCEAP
1371
AAAPE
1376
VSEEP
1381
RCPRA
1386
ACQAK
1391
RGDQR
1396
CDREC
1401
NSPGC
1406
GWDGG
1411
DCSLS
1416
VGDPW
1421
RQCEA
1426
LQCWR
1431
LFNNS
1436
RCDPA
1441
CSSPA
1446
CLYDN
1451
FDCHA
1456
GGRER
1461
TCNPV
1466
YEKYC
1471
ADHFA
1476
DGRCD
1481
QGCNT
1486
EECGW
1491
DGLDC
1496
ASEVP
1501
ALLAR
1506
GVLVL
1511
TVLLP
1516
PEELL
1521
RSSAD
1526
FLQRL
1531
SAILR
1536
TSLRF
1541
RLDAH
1546
GQAMV
1551
FPYHR
1556
PSPGS
1561
EPRAR
1566
RELAP
1571
EVIGS
1576
VVMLE
1581
IDNRL
1586
CLQSP
1591
ENDHC
1596
FPDAQ
1601
SAADY
1606
LGALS
1611
AVERL
1616
DFPYP
1621
LRDVR
1626
GEPLE
1631
PPEPS
1636
VPLLP
1641
LLVAG
1646
AVLLL
1651
VILVL
1656
GVMVA
1661
RRKRE
1666
HSTLW
1671
FPEGF
1676
SLHKD
1681
VASGH
1686
KGRRE
1691
PVGQD
1696
ALGMK
1701
NMAKG
1706
ESLMG
1711
EVATD
1716
WMDTE
1721
CPEAK
1726
RLKVE
1731
EPGMG
1736
AEEAV
1741
DCRQW
1746
TQHHL
1751
VAADI
1756
RVAPA
1761
MALTP
1766
PQGDA
1771
DADGM
1776
DVNVR
1781
GPDGF
1786
TPLML
1791
ASFCG
1796
GALEP
1801
MPTEE
1806
DEADD
1811
TSASI
1816
ISDLI
1821
CQGAQ
1826
LGART
1831
DRTGE
1836
TALHL
1841
AARYA
1846
RADAA
1851
KRLLD
1856
AGADT
1861
NAQDH
1866
SGRTP
1871
LHTAV
1876
TADAQ
1881
GVFQI
1886
LIRNR
1891
STDLD
1896
ARMAD
1901
GSTAL
1906
ILAAR
1911
LAVEG
1916
MVEEL
1921
IASHA
1926
DVNAV
1931
DELGK
1936
SALHW
1941
AAAVN
1946
NVEAT
1951
LALLK
1956
NGANK
1961
DMQDS
1966
KEETP
1971
LFLAA
1976
REGSY
1981
EAAKL
1986
LLDHF
1991
ANREI
1996
TDHLD
2001
RLPRD
2006
VAQER
2011
LHQDI
2016
VRLLD
2021
QPSGP
2026
RSPPG
2031
PHGLG
2036
PLLCP
2041
PGAFL
2046
PGLKA
2051
AQSGS
2056
KKSRR
2061
PPGKA
2066
GLGPQ
2071
GPRGR
2076
GKKLT
2081
LACPG
2086
PLADS
2091
SVTLS
2096
PVDSL
2101
DSPRP
2106
FGGPP
2111
ASPGG
2116
FPLEG
2121
PYAAA
2126
TATAV
2131
SLAQL
2136
GGPGR
2141
AGLGR
2146
QPPGG
2151
CVLSL
2156
GLLNP
2161
VAVPL
2166
DWARL
2171
PPPAP
2176
PGPSF
2181
LLPLA
2186
PGPQL
2191
LNPGT
2196
PVSPQ
2201
ERPPP
2206
YLAVP
2211
GHGEE
2216
YPAAG
2221
AHSSP
2226
PKARF
2231
LRVPS
2236
EHPYL
2241
TPSPE
2246
SPEHW
2251
ASPSP
2256
PSLSD
2261
WSEST
2266
PSPAT
2271
ATGAM
2276
ATTTG
2281
ALPAQ
2286
PLPLS
2291
VPSSL
2296
AQAQT
2301
QLGPQ
2306
PEVTP
2311
KRQVL
2316
A
2321
Mutation Information
DNA mutation:
None
Peptide Range:
1500 ~ 1524
Mut AA position:
1512 (13 in Wild Type peptide)
Alignment
Wild Type:
"CASEVPALLARGVLVLTVLLPPEEL
||||||||||||.||||||||||||
Mutant:
CASEVPALLARGMLVLTVLLPPEEL"
Science, 2015
Immunogenicity of somatic mutations in human gastrointestinal cancersGene Name (from Reference) NOTCH3
Checkpoint
Blockade
None
ACT
None
Vaccination
None
Curative
Effect
None
minimal_peptide
None
Antigen
Type
TMG RNA
T-cell
Source
TILs
APC
Type
autologous DCs
Assay
IFNg ELISPOT assay