Immunogenicity 2406
Sample ID
3978
Response
Negative
Tumor Type
Bile duct cancer
Gene Symbol
MACF1
Transcript ID
uc001cda.1
HLA INFO
A*02:01
TCR INFO
No TCR info found!
Full length protein sequence (3821 aa)
MKVRK
1
HINDL
6
YEDLR
11
DGHNL
16
ISLLE
21
VLSGI
26
KLPRE
31
KGRMR
36
FHRLQ
41
NVQIA
46
LDFLK
51
QRQVK
56
LVNIR
61
NDDIT
66
DGNPK
71
LTLGL
76
IWTII
81
LHFQI
86
SDIYI
91
SGESG
96
DMSAK
101
EKLLL
106
WTQKV
111
TAGYT
116
GIKCT
121
NFSSC
126
WSDGK
131
MFNAL
136
IHRYR
141
PDLVD
146
MERVQ
151
IQSNR
156
ENLEQ
161
AFEVA
166
ERLGV
171
TRLLD
176
AEDVD
181
VPSPD
186
EKSVI
191
TYVSS
196
IYDAF
201
PKVPE
206
GGEGI
211
SATEV
216
DSRWQ
221
EYQSR
226
VDSLI
231
PWIKQ
236
HTILM
241
SDKTF
246
PQNPV
251
ELKAL
256
YNQYI
261
HFKET
266
EILAK
271
EREKG
276
RIEEL
281
YKLLE
286
VWIEF
291
GRIKL
296
PQGYH
301
PNDVE
306
EEWGK
311
LIIEM
316
LEREK
321
SLRPA
326
VERLE
331
LLLQI
336
ANKIQ
341
NGALN
346
CEEKL
351
TLAKN
356
TLQAD
361
AAHLE
366
SGQPV
371
QCESD
376
VIMYI
381
QECEG
386
LIRQL
391
QVDLQ
396
ILRDE
401
NYYQL
406
EELAF
411
RVMRL
416
QDELV
421
TLRLE
426
CTNLY
431
RKGHF
436
TSLEL
441
VPPST
446
LTTTH
451
LKAEP
456
LTKAT
461
HSSST
466
SWFRK
471
PMTRA
476
ELVAI
481
SSSED
486
EGNLR
491
FVYEL
496
LSWVE
501
EMQMK
506
LERAE
511
WGNDL
516
PSVEL
521
QLETQ
526
QHIHT
531
SVEEL
536
GSSVK
541
EARLY
546
EGKMS
551
QNFHT
556
SYAET
561
LGKLE
566
TQYCK
571
LKETS
576
SFRMR
581
HLQSL
586
HKFVS
591
RATAE
596
LIWLN
601
EKEEE
606
ELAYD
611
WSDNN
616
SNISA
621
KRNYF
626
SELTM
631
ELEEK
636
QDVFR
641
SLQDT
646
AELLS
651
LENHP
656
AKQTV
661
EAYSA
666
AVQSQ
671
LQWMK
676
QLCLC
681
VEQHV
686
KENTA
691
YFQFF
696
SDARE
701
LESFL
706
RNLQD
711
SIKRK
716
YSCDH
721
NTSLS
726
RLEDL
731
LQDSM
736
DEKEQ
741
LIQSK
746
SSVAS
751
LVGRS
756
KTIVQ
761
LKPRS
766
PDHVL
771
KNTIS
776
VKAVC
781
DYRQI
786
EITIC
791
KNDEC
796
VLEDN
801
SQRTK
806
WKVIS
811
PTGNE
816
AMVPS
821
VCFLI
826
PPPNK
831
DAIEM
836
ASRVE
841
QSYQK
846
VMALW
851
HQLHV
856
NTKSL
861
ISWNY
866
LRKDL
871
DLVQT
876
WNLEK
881
LRSSA
886
PGECH
891
QIMKN
896
LQAHY
901
EDFLQ
906
DSRDS
911
VLFSV
916
ADRLR
921
LEEEV
926
EACKA
931
RFQHL
936
MKSME
941
NEDKE
946
ETVAK
951
MYISE
956
LKNIR
961
LRLEE
966
YEQRV
971
VKRIQ
976
SLASS
981
RTDRD
986
AWQDN
991
ALRIA
996
EQEHT
1001
QEDLQ
1006
QLRSD
1011
LDAVS
1016
MKCDS
1021
FLHQS
1026
PSSSS
1031
VPTLR
1036
SELNL
1041
LVEKM
1046
DHVYG
1051
LSTVY
1056
LNKLK
1061
TVDVI
1066
VRSIQ
1071
DAELL
1076
VKGYE
1081
IKLSQ
1086
EEVVL
1091
ADLSA
1096
LEAHW
1101
STLRH
1106
WLSDV
1111
KDKNS
1116
VFSVL
1121
DEEIA
1126
KAKVV
1131
AEQMS
1136
RLTPE
1141
RNLDL
1146
ERYQE
1151
KGSQL
1156
QERWH
1161
RVIAQ
1166
LEIRQ
1171
SELES
1176
IQEVL
1181
GDYRA
1186
CHGTL
1191
IKWIE
1196
ETTAQ
1201
QEMMK
1206
PGQAE
1211
DSRVL
1216
SEQLS
1221
QQTAL
1226
FAEIE
1231
RNQTK
1236
LDQCQ
1241
KFSQQ
1246
YSTIV
1251
KDYEL
1256
QLMTY
1261
KAFVE
1266
SQQKS
1271
PGKRR
1276
RMLSS
1281
SDAIT
1286
QEFMD
1291
LRTRY
1296
TALVT
1301
LTTQH
1306
VKYIS
1311
DALRR
1316
LEEEE
1321
KVVEE
1326
EKQEH
1331
VEKVK
1336
ELLGW
1341
VSTLA
1346
RNTQG
1351
KATSS
1356
ETKES
1361
TDIEK
1366
AILEQ
1371
QVLSE
1376
ELTTK
1381
KEQVS
1386
EAIKT
1391
SQIFL
1396
AKHGH
1401
KLSEK
1406
EKKQI
1411
SEQLN
1416
ALNKA
1421
YHDLC
1426
DGSAN
1431
QLQQL
1436
QSQLA
1441
HQTEQ
1446
KTLQK
1451
QQNTC
1456
HQQLE
1461
DLCSW
1466
VGQAE
1471
RALAG
1476
HQGRT
1481
TQQDL
1486
SALQK
1491
NQSDL
1496
KDLQD
1501
DIQNR
1506
ATSFA
1511
TVVKD
1516
IEGFM
1521
EENQT
1526
KLSPR
1531
ELTAL
1536
REKLH
1541
QAKEQ
1546
YEALQ
1551
EETRV
1556
AQKEL
1561
EEAVT
1566
SALQQ
1571
ETEKS
1576
KAAKE
1581
LAENK
1586
KKIDA
1591
LLDWV
1596
TSVGS
1601
SGGQL
1606
LTNLP
1611
GMEQL
1616
SGASL
1621
EKGAL
1626
DTTDG
1631
YMGVN
1636
QAPEK
1641
LDKQC
1646
EMMKA
1651
RHQEL
1656
LSQQQ
1661
NFILA
1666
TQSAQ
1671
AFLDQ
1676
HGHNL
1681
TPEEQ
1686
QMLQQ
1691
KLGEL
1696
KEQYS
1701
TSLAQ
1706
SEAEL
1711
KQVQT
1716
LQDEL
1721
QKFLQ
1726
DHKEF
1731
ESWLE
1736
RSEKE
1741
LENMH
1746
KGGSS
1751
PETLP
1756
SLLKR
1761
QGSFS
1766
EDVIS
1771
HKGDL
1776
RFVTI
1781
SGQKV
1786
LDMEN
1791
SFKEG
1796
KEPSE
1801
IGNLV
1806
KDKLK
1811
DATER
1816
YTALH
1821
SKCTR
1826
LGSHL
1831
NMLLG
1836
QYHQF
1841
QNSAD
1846
SLQAW
1851
MQACE
1856
ANVEK
1861
LLSDT
1866
VASDP
1871
GVLQE
1876
QLATT
1881
KQLQE
1886
ELAEH
1891
QVPVE
1896
KLQKV
1901
ARDIM
1906
EIEGE
1911
PAPDH
1916
RHVQE
1921
TTDSI
1926
LSHFQ
1931
SLSYS
1936
LAERS
1941
SLLQK
1946
AIAQS
1951
QSVQE
1956
SLESL
1961
LQSIG
1966
EVEQN
1971
LEGKQ
1976
VSSLS
1981
SGVIQ
1986
EALAT
1991
NMKLK
1996
QDIAR
2001
QKSSL
2006
EATRE
2011
MVTRF
2016
METAD
2021
STTAA
2026
VLQGK
2031
LAEVS
2036
QRFEQ
2041
LCLQQ
2046
QEKES
2051
SLKKL
2056
LPQAE
2061
MFEHL
2066
SGKLQ
2071
QFMEN
2076
KSRML
2081
ASGNQ
2086
PDQDI
2091
THFFQ
2096
QIQEL
2101
NLEME
2106
DQQEN
2111
LDTLE
2116
HLVTE
2121
LSSCG
2126
FALDL
2131
CQHQD
2136
RVQNL
2141
RKDFT
2146
ELQKT
2151
VKERE
2156
KDASS
2161
CQEQL
2166
DEFRK
2171
LVRTF
2176
QKWLK
2181
ETEGS
2186
IPPTE
2191
TSMSA
2196
KELEK
2201
QIEHL
2206
KSLLD
2211
DWASK
2216
GTLVE
2221
EINCK
2226
GTSLE
2231
NLIME
2236
ITAPD
2241
SQGKT
2246
DLTEI
2251
QCDMS
2256
DVNLK
2261
YEKLG
2266
GVLHE
2271
RQESL
2276
QAILN
2281
RMEEV
2286
HKEAN
2291
SVLQW
2296
LESKE
2301
EVLKS
2306
MDAMS
2311
SPTKT
2316
ETVKA
2321
QAESN
2326
KAFLA
2331
ELEQN
2336
SPKIQ
2341
KVKEA
2346
LAGLL
2351
VTYPN
2356
SQEAE
2361
NWKKI
2366
QEELN
2371
SRWER
2376
ATEVT
2381
VARQR
2386
QLEES
2391
ASHLA
2396
CFQAA
2401
ESQLR
2406
PWLME
2411
KELMM
2416
GVLGP
2421
LSIDP
2426
NMLNA
2431
QKQQV
2436
QFMLK
2441
EFEAR
2446
RQQHE
2451
QLNEA
2456
AQGIL
2461
TGPGD
2466
VSLST
2471
SQVQK
2476
ELQSI
2481
NQKWV
2486
ELTDK
2491
LNSRS
2496
SQIDQ
2501
AIVKS
2506
TQYQE
2511
LLQDL
2516
SEKVR
2521
AVGQR
2526
LSVQS
2531
AISTQ
2536
PEAVK
2541
QQLEE
2546
TSEIR
2551
SDLEQ
2556
LDHEV
2561
KEAQT
2566
LCDEL
2571
SVLIG
2576
EQYLK
2581
DELKK
2586
RLETV
2591
ALPLQ
2596
GLEDL
2601
AADRI
2606
NRLQA
2611
ALAST
2616
QQFQQ
2621
MFDEL
2626
RTWLD
2631
DKQSQ
2636
QAKNC
2641
PISAK
2646
LERLQ
2651
SQLQE
2656
NEEFQ
2661
KSLNQ
2666
HSGSY
2671
EVIVA
2676
EGESL
2681
LLSVP
2686
PGEEK
2691
RTLQN
2696
QLVEL
2701
KNHWE
2706
ELSKK
2711
TADRQ
2716
SRLKD
2721
CMQKA
2726
QKYQW
2731
HVEDL
2736
VPWIE
2741
DCKAK
2746
MSELR
2751
VTLDP
2756
VQLES
2761
SLLRS
2766
KAMLN
2771
EVEKR
2776
RSLLE
2781
ILNSA
2786
ADILI
2791
NSSEA
2796
DEDGI
2801
RDEKA
2806
GINQN
2811
MDAVT
2816
EELQA
2821
KTGSL
2826
EEMTQ
2831
RLREF
2836
QESFK
2841
NIEKK
2846
VEGAK
2851
HQLEI
2856
FDALG
2861
SQACS
2866
NKNLE
2871
KLRAQ
2876
QEVLQ
2881
ALEPQ
2886
VDYLR
2891
NFTQG
2896
LVEDA
2901
PDGSD
2906
ASQLL
2911
HQAEV
2916
AQQEF
2921
LEVKQ
2926
RVNSG
2931
CVMME
2936
NKLEG
2941
IGQFH
2946
CRVRE
2951
MFSQL
2956
ADLDD
2961
ELDGM
2966
GAIGR
2971
DTDSL
2976
QSQIE
2981
DVRLF
2986
LNKIH
2991
VLKLD
2996
IEASE
3001
AECRH
3006
MLEEE
3011
GTLDL
3016
LGLKR
3021
ELEAL
3026
NKQCG
3031
KLTER
3036
GKARQ
3041
EQLEL
3046
TLGRV
3051
EDFYR
3056
KLKGL
3061
NDATT
3066
AAEEA
3071
EALQW
3076
VVGTE
3081
VEIIN
3086
QQLAD
3091
FKMFQ
3096
KEQVD
3101
PLQMK
3106
LQQVN
3111
GLGQG
3116
LIQSA
3121
GKDCD
3126
VQGLE
3131
HDMEE
3136
INARW
3141
NTLNK
3146
KVAQR
3151
IAQLQ
3156
EALLH
3161
CGKFQ
3166
DALEP
3171
LLSWL
3176
ADTEE
3181
LIANQ
3186
KPPSA
3191
EYKVV
3196
KAQIQ
3201
EQKLL
3206
QRLLD
3211
DRKAT
3216
VDMLQ
3221
AEGGR
3226
IAQSA
3231
ELADR
3236
EKITG
3241
QLESL
3246
ESRWT
3251
ELLSK
3256
AAARQ
3261
KQLED
3266
ILVLA
3271
KQFHE
3276
TAEPI
3281
SDFLS
3286
VTEKK
3291
LANSE
3296
PVGTQ
3301
TAKIQ
3306
QQIIR
3311
HKALE
3316
EDIEN
3321
HATDV
3326
HQAVK
3331
IGQSL
3336
SSLTS
3341
PAEQG
3346
VLSEK
3351
IDSLQ
3356
ARYSE
3361
IQDRC
3366
CRKAA
3371
LLDQA
3376
LSNAR
3381
LFGED
3386
EVEVL
3391
NWLAE
3396
VEDKL
3401
SSVFV
3406
KDFKQ
3411
DVLHR
3416
QHADH
3421
LALNE
3426
EIVNR
3431
KKNVD
3436
QAIKN
3441
GQALL
3446
KQTTG
3451
EEVLL
3456
IQEKL
3461
DGIKT
3466
RYADI
3471
TVTSS
3476
KALRT
3481
LEQAR
3486
QLATK
3491
FQSTY
3496
EELTG
3501
WLREV
3506
EEELA
3511
TSGGQ
3516
SPTGE
3521
QIPQF
3526
QQRQK
3531
ELKKE
3536
VMEHR
3541
LVLDT
3546
VNEVS
3551
RALLE
3556
LVPWR
3561
AREGL
3566
DKLVS
3571
DANEQ
3576
YKLVS
3581
DTIGQ
3586
RVDEI
3591
DAAIQ
3596
RSQQY
3601
EQAAD
3606
AELAW
3611
VAETK
3616
RKLMA
3621
LGPIR
3626
LEQDQ
3631
TTAQL
3636
QVQKA
3641
FSIDI
3646
IRHKD
3651
SMDEL
3656
FSHRS
3661
EIFGT
3666
CGEEQ
3671
KTVLQ
3676
EKTES
3681
LIQQY
3686
EAISL
3691
LNSER
3696
YARLE
3701
RAQVL
3706
VNQFW
3711
ETYEE
3716
LSPWI
3721
EETRA
3726
LIAQL
3731
PSPAI
3736
DHEQL
3741
RQQQE
3746
EMRQL
3751
RESIA
3756
EHKPH
3761
IDKLL
3766
KIGPQ
3771
LKELN
3776
PEEGE
3781
MVEEK
3786
YQKAE
3791
NMYAQ
3796
IKEEV
3801
RQRAL
3806
ALDEA
3811
VSQST
3816
Q
3821
Mutation Information
DNA mutation:
None
Peptide Range:
2989 ~ 3013
Mut AA position:
3001 (13 in Wild Type peptide)
Alignment
Wild Type:
"LFLNKIHVLKLDIEASEAECRHMLE
||||||||||||.||||||||||||
Mutant:
LFLNKIHVLKLDTEASEAECRHMLE"
Science, 2015
Immunogenicity of somatic mutations in human gastrointestinal cancersGene Name (from Reference) MACF1
Checkpoint
Blockade
None
ACT
None
Vaccination
None
Curative
Effect
None
minimal_peptide
None
Antigen
Type
TMG RNA
T-cell
Source
TILs
APC
Type
autologous DCs
Assay
IFNg ELISPOT assay