Immunogenicity 243
Sample ID
4196
Response
Negative
Tumor Type
Colorectal cancer
Gene Symbol
POLR2A
Transcript ID
uc002ghf.4
HLA INFO
A*24:01
TCR INFO
No TCR info found!
Full length protein sequence (1970 aa)
MHGGG
1
PPSGD
6
SACPL
11
RTIKR
16
VQFGV
21
LSPDE
26
LKRMS
31
VTEGG
36
IKYPE
41
TTEGG
46
RPKLG
51
GLMDP
56
RQGVI
61
ERTGR
66
CQTCA
71
GNMTE
76
CPGHF
81
GHIEL
86
AKPVF
91
HVGFL
96
VKTMK
101
VLRCV
106
CFFCS
111
KLLVD
116
SNNPK
121
IKDIL
126
AKSKG
131
QPKKR
136
LTHVY
141
DLCKG
146
KNICE
151
GGEEM
156
DNKFG
161
VEQPE
166
GDEDL
171
TKEKG
176
HGGCG
181
RYQPR
186
IRRSG
191
LELYA
196
EWKHV
201
NEDSQ
206
EKKIL
211
LSPER
216
VHEIF
221
KRISD
226
EECFV
231
LGMEP
236
RYARP
241
EWMIV
246
TVLPV
251
PPLSV
256
RPAVV
261
MQGSA
266
RNQDD
271
LTHKL
276
ADIVK
281
INNQL
286
RRNEQ
291
NGAAA
296
HVIAE
301
DVKLL
306
QFHVA
311
TMVDN
316
ELPGL
321
PRAMQ
326
KSGRP
331
LKSLK
336
QRLKG
341
KEGRV
346
RGNLM
351
GKRVD
356
FSART
361
VITPD
366
PNLSI
371
DQVGV
376
PRSIA
381
ANMTF
386
AEIVT
391
PFNID
396
RLQEL
401
VRRGN
406
SQYPG
411
AKYII
416
RDNGD
421
RIDLR
426
FHPKP
431
SDLHL
436
QTGYK
441
VERHM
446
CDGDI
451
VIFNR
456
QPTLH
461
KMSMM
466
GHRVR
471
ILPWS
476
TFRLN
481
LSVTT
486
PYNAD
491
FDGDE
496
MNLHL
501
PQSLE
506
TRAEI
511
QELAM
516
VPRMI
521
VTPQS
526
NRPVM
531
GIVQD
536
TLTAV
541
RKFTK
546
RDVFL
551
ERGEV
556
MNLLM
561
FLSTW
566
DGKVP
571
QPAIL
576
KPRPL
581
WTGKQ
586
IFSLI
591
IPGHI
596
NCIRT
601
HSTHP
606
DDEDS
611
GPYKH
616
ISPGD
621
TKVVV
626
ENGEL
631
IMGIL
636
CKKSL
641
GTSAG
646
SLVHI
651
SYLEM
656
GHDIT
661
RLFYS
666
NIQTV
671
INNWL
676
LIEGH
681
TIGIG
686
DSIAD
691
SKTYQ
696
DIQNT
701
IKKAK
706
QDVIE
711
VIEKA
716
HNNEL
721
EPTPG
726
NTLRQ
731
TFENQ
736
VNRIL
741
NDARD
746
KTGSS
751
AQKSL
756
SEYNN
761
FKSMV
766
VSGAK
771
GSKIN
776
ISQVI
781
AVVGQ
786
QNVEG
791
KRIPF
796
GFKHR
801
TLPHF
806
IKDDY
811
GPESR
816
GFVEN
821
SYLAG
826
LTPTE
831
FFFHA
836
MGGRE
841
GLIDT
846
AVKTA
851
ETGYI
856
QRRLI
861
KSMES
866
VMVKY
871
DATVR
876
NSINQ
881
VVQLR
886
YGEDG
891
LAGES
896
VEFQN
901
LATLK
906
PSNKA
911
FEKKF
916
RFDYT
921
NERAL
926
RRTLQ
931
EDLVK
936
DVLSN
941
AHIQN
946
ELERE
951
FERMR
956
EDREV
961
LRVIF
966
PTGDS
971
KVVLP
976
CNLLR
981
MIWNA
986
QKIFH
991
INPRL
996
PSDLH
1001
PIKVV
1006
EGVKE
1011
LSKKL
1016
VIVNG
1021
DDPLS
1026
RQAQE
1031
NATLL
1036
FNIHL
1041
RSTLC
1046
SRRMA
1051
EEFRL
1056
SGEAF
1061
DWLLG
1066
EIESK
1071
FNQAI
1076
AHPGE
1081
MVGAL
1086
AAQSL
1091
GEPAT
1096
QMTLN
1101
TFHYA
1106
GVSAK
1111
NVTLG
1116
VPRLK
1121
ELINI
1126
SKKPK
1131
TPSLT
1136
VFLLG
1141
QSARD
1146
AERAK
1151
DILCR
1156
LEHTT
1161
LRKVT
1166
ANTAI
1171
YYDPN
1176
PQSTV
1181
VAEDQ
1186
EWVNV
1191
YYEMP
1196
DFDVA
1201
RISPW
1206
LLRVE
1211
LDRKH
1216
MTDRK
1221
LTMEQ
1226
IAEKI
1231
NAGFG
1236
DDLNC
1241
IFNDD
1246
NAEKL
1251
VLRIR
1256
IMNSD
1261
ENKMQ
1266
EEEEV
1271
VDKMD
1276
DDVFL
1281
RCIES
1286
NMLTD
1291
MTLQG
1296
IEQIS
1301
KVYMH
1306
LPQTD
1311
NKKKI
1316
IITED
1321
GEFKA
1326
LQEWI
1331
LETDG
1336
VSLMR
1341
VLSEK
1346
DVDPV
1351
RTTSN
1356
DIVEI
1361
FTVLG
1366
IEAVR
1371
KALER
1376
ELYHV
1381
ISFDG
1386
SYVNY
1391
RHLAL
1396
LCDTM
1401
TCRGH
1406
LMAIT
1411
RHGVN
1416
RQDTG
1421
PLMKC
1426
SFEET
1431
VDVLM
1436
EAAAH
1441
GESDP
1446
MKGVS
1451
ENIML
1456
GQLAP
1461
AGTGC
1466
FDLLL
1471
DAEKC
1476
KYGME
1481
IPTNI
1486
PGLGA
1491
AGPTG
1496
MFFGS
1501
APSPM
1506
GGISP
1511
AMTPW
1516
NQGAT
1521
PAYGA
1526
WSPSV
1531
GSGMT
1536
PGAAG
1541
FSPSA
1546
ASDAS
1551
GFSPG
1556
YSPAW
1561
SPTPG
1566
SPGSP
1571
GPSSP
1576
YIPSP
1581
GGAMS
1586
PSYSP
1591
TSPAY
1596
EPRSP
1601
GGYTP
1606
QSPSY
1611
SPTSP
1616
SYSPT
1621
SPSYS
1626
PTSPN
1631
YSPTS
1636
PSYSP
1641
TSPSY
1646
SPTSP
1651
SYSPT
1656
SPSYS
1661
PTSPS
1666
YSPTS
1671
PSYSP
1676
TSPSY
1681
SPTSP
1686
SYSPT
1691
SPSYS
1696
PTSPS
1701
YSPTS
1706
PSYSP
1711
TSPSY
1716
SPTSP
1721
SYSPT
1726
SPSYS
1731
PTSPS
1736
YSPTS
1741
PNYSP
1746
TSPNY
1751
TPTSP
1756
SYSPT
1761
SPSYS
1766
PTSPN
1771
YTPTS
1776
PNYSP
1781
TSPSY
1786
SPTSP
1791
SYSPT
1796
SPSYS
1801
PSSPR
1806
YTPQS
1811
PTYTP
1816
SSPSY
1821
SPSSP
1826
SYSPT
1831
SPKYT
1836
PTSPS
1841
YSPSS
1846
PEYTP
1851
TSPKY
1856
SPTSP
1861
KYSPT
1866
SPKYS
1871
PTSPT
1876
YSPTT
1881
PKYSP
1886
TSPTY
1891
SPTSP
1896
VYTPT
1901
SPKYS
1906
PTSPT
1911
YSPTS
1916
PKYSP
1921
TSPTY
1926
SPTSP
1931
KGSTY
1936
SPTSP
1941
GYSPT
1946
SPTYS
1951
LTSPA
1956
ISPDD
1961
SDEEN
1966
Mutation Information
DNA mutation:
c.T4112C
Peptide Range:
1359 ~ 1383
Mut AA position:
1371 (13 in Wild Type peptide)
Alignment
Wild Type:
"SNDIVEIFTVLGIEAVRKALERELY
||||||||||||.||||||||||||
Mutant:
SNDIVEIFTVLGTEAVRKALERELY"
Cancer Immunol Res, 2019
Immunologic Recognition of a Shared p53 Mutated Neoantigen in a Patient with Metastatic Colorectal CancerGene Name (from Reference) POLR2A
Checkpoint
Blockade
None
ACT
None
Vaccination
None
Curative
Effect
None
minimal_peptide
SNDIVEIFTVLGTEAVRKALERELY
Antigen
Type
TMG
T-cell
Source
TILs
APC
Type
DSs
Assay
ELISPOT