Immunogenicity 283
Sample ID
4196
Response
Negative
Tumor Type
Colorectal cancer
Gene Symbol
ITPR2
Transcript ID
uc001rhg.3
HLA INFO
A*24:01
TCR INFO
No TCR info found!
Full length protein sequence (2701 aa)
MTEKM
1
SSFLY
6
IGDIV
11
SLYAE
16
GSVNG
21
FISTL
26
GLVDD
31
RCVVH
36
PEAGD
41
LANPP
46
KKFRD
51
CLFKV
56
CPMNR
61
YSAQK
66
QYWKA
71
KQAKQ
76
GNHTE
81
AALLK
86
KLQHA
91
AELEQ
96
KQNES
101
ENKKL
106
LGEIV
111
KYSNV
116
IQLLH
121
IKSNK
126
YLTVN
131
KRLPA
136
LLEKN
141
AMRVS
146
LDAAG
151
NEGSW
156
FYIHP
161
FWKLR
166
SEGDN
171
IVVGD
176
KVVLM
181
PVNAG
186
QPLHA
191
SNIEL
196
LDNPG
201
CKEVN
206
AVNCN
211
TSWKI
216
TLFMK
221
YSSYR
226
EDVLK
231
GGDVV
236
RLFHA
241
EQEKF
246
LTCDE
251
YEKKQ
256
HIFLR
261
TTLRQ
266
SATSA
271
TSSKA
276
LWEIE
281
VVHHD
286
PCRGG
291
AGQWN
296
SLFRF
301
KHLAT
306
GNYLA
311
AELNP
316
DYRDA
321
QNEGK
326
NVRDG
331
VPPTS
336
KKKRQ
341
AGEKI
346
MYTLV
351
SVPHG
356
NDIAS
361
LFELD
366
ATTLQ
371
RADCL
376
VPRNS
381
YVRLR
386
HLCTN
391
TWVTS
396
TSIPI
401
DTDEE
406
RPVML
411
KIGTC
416
QTKED
421
KEAFA
426
IVSVP
431
LSEVR
436
DLDFA
441
NDANK
446
VLATT
451
VKKLE
456
NGTIT
461
QNERR
466
FVTKL
471
LEDLI
476
FFVAD
481
VPNNG
486
QEVLD
491
VVITK
496
PNRER
501
QKLMR
506
EQNIL
511
AQVFG
516
ILKAP
521
FKEKA
526
GEGSM
531
LRLED
536
LGDQR
541
YAPYK
546
YMLRL
551
CYRVL
556
RHSQQ
561
DYRKN
566
QEYIA
571
KNFCV
576
MQSQI
581
GYDIL
586
AEDTI
591
TALLH
596
NNRKL
601
LEKHI
606
TAKEI
611
ETFVS
616
LLRRN
621
REPRF
626
LDYLS
631
DLCVS
636
NTTAI
641
PVTQE
646
LICKF
651
MLSPG
656
NADIL
661
IQTKV
666
VSMQA
671
DNPME
676
SSILS
681
DDIDD
686
EEVWL
691
YWIDS
696
NKEPH
701
GKAIR
706
HLAQE
711
AKEGT
716
KADLE
721
VLTYY
726
RYQLN
731
LFARM
736
CLDRQ
741
YLAIN
746
QISTQ
751
LSVDL
756
ILRCV
761
SDESL
766
PFDLR
771
ASFCR
776
LMLHM
781
HVDRD
786
PQESV
791
VPVRY
796
ARLWT
801
EIPTK
806
ITIHE
811
YDSIT
816
DSSRN
821
DMKRK
826
FALTM
831
EFVEE
836
YLKEV
841
VNQPF
846
PFGDK
851
EKNKL
856
TFEVV
861
HLARN
866
LIYFG
871
FYSFS
876
ELLRL
881
TRTLL
886
AILDI
891
VQAPM
896
SSYFE
901
RLSKF
906
QDGGN
911
NVMRT
916
IHGVG
921
EMMTQ
926
MVLSR
931
GSIFP
936
MSVPD
941
VPPSI
946
HPSKQ
951
GSPTE
956
HEDVT
961
VMDTK
966
LKIIE
971
ILQFI
976
LSVRL
981
DYRIS
986
YMLSI
991
YKKEF
996
GEDND
1001
NAETS
1006
ASGSP
1011
DTLLP
1016
SAIVP
1021
DIDEI
1026
AAQAE
1031
TMFAG
1036
RKEKN
1041
PVQLD
1046
DEGGR
1051
TFLRV
1056
LIHLI
1061
MHDYP
1066
PLLSG
1071
ALQLL
1076
FKHFS
1081
QRAEV
1086
LQAFK
1091
QVQLL
1096
VSNQD
1101
VDNYK
1106
QIKAD
1111
LDQLR
1116
LTVEK
1121
SELWV
1126
EKSSN
1131
YENGE
1136
IGESQ
1141
VKGGE
1146
EPIEE
1151
SNILS
1156
PVQDG
1161
TKKPQ
1166
IDSNK
1171
SNNYR
1176
IVKEI
1181
LIRLS
1186
KLCVQ
1191
NKKCR
1196
NQHQR
1201
LLKNM
1206
GAHSV
1211
VLDLL
1216
QIPYE
1221
KNDEK
1226
MNEVM
1231
NLAHT
1236
FLQNF
1241
CRGNP
1246
QNQVL
1251
LHKHL
1256
NLFLT
1261
PGLLE
1266
AETMR
1271
HIFMN
1276
NYHLC
1281
NEISE
1286
RVVQH
1291
FVHCI
1296
ETHGR
1301
HVEYL
1306
RFLQT
1311
IVKAD
1316
GKYVK
1321
KCQDM
1326
VMTEL
1331
INGGE
1336
DVLIF
1341
YNDRA
1346
SFPIL
1351
LHMMC
1356
SERDR
1361
GDESG
1366
PLAYH
1371
ITLVE
1376
LLAAC
1381
TEGKN
1386
VYTEI
1391
KCNSL
1396
LPLDD
1401
IVRVV
1406
THDDC
1411
IPEVK
1416
IAYVN
1421
FVNHC
1426
YVDTE
1431
VEMKE
1436
IYTSN
1441
HIWKL
1446
FENFL
1451
VDMAR
1456
VCNTT
1461
TDRKH
1466
ADIFL
1471
EKCVT
1476
ESIMN
1481
IVSGF
1486
FNSPF
1491
SDNST
1496
SLQTH
1501
QPVFI
1506
QLLQS
1511
AFRIY
1516
NCTWP
1521
NPAQK
1526
ASVES
1531
CIRTL
1536
AEVAK
1541
NRGIA
1546
IPVDL
1551
DSQVN
1556
TLFMK
1561
SHSNM
1566
VQRAA
1571
MGWRL
1576
SARSG
1581
PRFKE
1586
ALGGP
1591
AWDYR
1596
NIIEK
1601
LQDVV
1606
ASLEH
1611
QFSPM
1616
MQAEF
1621
SVLVD
1626
VLYSP
1631
ELLFP
1636
EGSDA
1641
RIRCG
1646
AFMSK
1651
LINHT
1656
KKLME
1661
KEEKL
1666
CIKIL
1671
QTLRE
1676
MLEKK
1681
DSFVE
1686
EGNTL
1691
RKILL
1696
NRYFK
1701
GDYSI
1706
GVNGH
1711
LSGAY
1716
SKTAQ
1721
VGGSF
1726
SGQDS
1731
DKMGI
1736
SMSDI
1741
QCLLD
1746
KEGAS
1751
ELVID
1756
VIVNT
1761
KNDRI
1766
FSEGI
1771
FLGIA
1776
LLEGG
1781
NTQTQ
1786
YSFYQ
1791
QLHEQ
1796
KKSEK
1801
FFKVL
1806
YDRMK
1811
AAQKE
1816
IRSTV
1821
TVNTI
1826
DLGNK
1831
KRDDD
1836
NELMT
1841
SGPRM
1846
RVRDS
1851
TLHLK
1856
EGMKG
1861
QLTEA
1866
SSATS
1871
KAYCV
1876
YRREM
1881
DPEID
1886
IMCTG
1891
PEAGN
1896
TEEKS
1901
AEEVT
1906
MSPAI
1911
AIMQP
1916
ILRFL
1921
QLLCE
1926
NHNRE
1931
LQNFL
1936
RNQNN
1941
KTNYN
1946
LVCET
1951
LQFLD
1956
CICGS
1961
TTGGL
1966
GLLGL
1971
YINEK
1976
NVALV
1981
NQNLE
1986
SLTEY
1991
CQGPC
1996
HENQT
2001
CIATH
2006
ESNGI
2011
DIIIA
2016
LILND
2021
INPLG
2026
KYRMD
2031
LVLQL
2036
KNNAS
2041
KLLLA
2046
IMESR
2051
HDSEN
2056
AERIL
2061
FNMRP
2066
RELVD
2071
VMKNA
2076
YNQGL
2081
ECDHG
2086
DDEGG
2091
DDGVS
2096
PKDVG
2101
HNIYI
2106
LAHQL
2111
ARHNK
2116
LLQQM
2121
LKPGS
2126
DPDEG
2131
DEALK
2136
YYANH
2141
TAQIE
2146
IVRHD
2151
RTMEQ
2156
IVFPV
2161
PNICE
2166
YLTRE
2171
SKCRV
2176
FNTTE
2181
RDEQG
2186
SKVND
2191
FFQQT
2196
EDLYN
2201
EMKWQ
2206
KKIRN
2211
NPALF
2216
WFSRH
2221
ISLWG
2226
SISFN
2231
LAVFI
2236
NLAVA
2241
LFYPF
2246
GDDGD
2251
EGTLS
2256
PLFSV
2261
LLWIA
2266
VAICT
2271
SMLFF
2276
FSKPV
2281
GIRPF
2286
LVSIM
2291
LRSIY
2296
TIGLG
2301
PTLIL
2306
LGAAN
2311
LCNKI
2316
VFLVS
2321
FVGNR
2326
GTFTR
2331
GYRAV
2336
ILDMA
2341
FLYHV
2346
AYVLV
2351
CMLGL
2356
FVHEF
2361
FYSFL
2366
LFDLV
2371
YREET
2376
LLNVI
2381
KSVTR
2386
NGRSI
2391
ILTAV
2396
LALIL
2401
VYLFS
2406
IIGFL
2411
FLKDD
2416
FTMEV
2421
DRLKN
2426
RTPVT
2431
GSHQV
2436
PTMTL
2441
TTMME
2446
ACAKE
2451
NCSPT
2456
IPASN
2461
TADEE
2466
YEDGI
2471
ERTCD
2476
TLLMC
2481
IVTVL
2486
NQGLR
2491
NGGGV
2496
GDVLR
2501
RPSKD
2506
EPLFA
2511
ARVVY
2516
DLLFY
2521
FIVII
2526
IVLNL
2531
IFGVI
2536
IDTFA
2541
DLRSE
2546
KQKKE
2551
EILKT
2556
TCFIC
2561
GLERD
2566
KFDNK
2571
TVSFE
2576
EHIKS
2581
EHNMW
2586
HYLYF
2591
IVLVK
2596
VKDPT
2601
EYTGP
2606
ESYVA
2611
QMIVE
2616
KNLDW
2621
FPRMR
2626
AMSLV
2631
SNEGD
2636
SEQNE
2641
IRSLQ
2646
EKLES
2651
TMSLV
2656
KQLSG
2661
QLAEL
2666
KEQMT
2671
EQRKN
2676
KQRLG
2681
FLGSN
2686
TPHVN
2691
HHMPP
2696
H
2701
Mutation Information
DNA mutation:
c.G1673A
Peptide Range:
546 ~ 570
Mut AA position:
558 (13 in Wild Type peptide)
Alignment
Wild Type:
"YAPYKYMLRLCYRVLRHSQQDYRKN
||||||||||||.||||||||||||
Mutant:
YAPYKYMLRLCYHVLRHSQQDYRKN"
Cancer Immunol Res, 2019
Immunologic Recognition of a Shared p53 Mutated Neoantigen in a Patient with Metastatic Colorectal CancerGene Name (from Reference) ITPR2
Checkpoint
Blockade
None
ACT
None
Vaccination
None
Curative
Effect
None
minimal_peptide
YAPYKYMLRLCYHVLRHSQQDYRKN
Antigen
Type
TMG
T-cell
Source
TILs
APC
Type
DSs
Assay
ELISPOT