Immunogenicity 3011

summary
Sample ID
4032
Response
Negative
Tumor Type
Colon cancer
Gene Symbol
PCSK6
Transcript ID
uc010bpd.3
HLA INFO
C*05:01
TCR INFO

No TCR info found!

T cell Tumor cell C*05:01
sequence
Full length protein sequence (765 aa)
MDPQV
1
KWLQQ
6
QEVKR
11
RVKRQ
16
VRSDP
21
QALYF
26
NDPIW
31
SNMWY
36
LHCGD
41
KNSRC
46
RSEMN
51
VQAAW
56
KRGYT
61
GKNVV
66
VTILD
71
DGIER
76
NHPDL
81
APNYD
86
SYASY
91
DVNGN
96
DYDPS
101
PRYDA
106
SNENK
111
HGTRC
116
AGEVA
121
ASANN
126
SYCIV
131
GIAYN
136
AKIGG
141
IRMLD
146
GDVTD
151
VVEAK
156
SLGIR
161
PNYID
166
IYSAS
171
WGPDD
176
DGKTV
181
DGPGR
186
LAKQA
191
FEYGI
196
KKGRQ
201
GLGSI
206
FVWAS
211
GNGGR
216
EGDYC
221
SCDGY
226
TNSIY
231
TISVS
236
SATEN
241
GYKPW
246
YLEEC
251
ASTLA
256
TTYSS
261
GAFYE
266
RKIVT
271
TDLRQ
276
RCTDG
281
HTGTS
286
VSAPM
291
VAGII
296
ALALE
301
AKSIP
306
LVQVL
311
RTTAL
316
TSACA
321
EHSDQ
326
RVVYL
331
EHVVV
336
RTSIS
341
HPRRG
346
DLQIY
351
LVSPS
356
GTKSQ
361
LLAKR
366
LLDLS
371
NEGFT
376
NWEFM
381
TVHCW
386
GEKAE
391
GQWTL
396
EIQDL
401
PSQVR
406
NPEKQ
411
GKLKE
416
WSLIL
421
YGTAE
426
HPYHT
431
FSAHQ
436
SRSRM
441
LELSA
446
PELEP
451
PKAAL
456
SPSQV
461
EVPED
466
EEDYT
471
AQSTP
476
GSANI
481
LQTSV
486
CHPEC
491
GDKGC
496
DGPNA
501
DQCLN
506
CVHFS
511
LGSVK
516
TSRKC
521
VSVCP
526
LGYFG
531
DTAAR
536
RCRRC
541
HKGCE
546
TCSSR
551
AATQC
556
LSCRR
561
GFYHH
566
QEMNT
571
CVTLC
576
PAGFY
581
ADESQ
586
KNCLK
591
CHPSC
596
KKCVD
601
EPEKC
606
TVCKE
611
GFSLA
616
RGSCI
621
PDCEP
626
GTYFD
631
SELIR
636
CGECH
641
HTCGT
646
CVGPG
651
REECI
656
HCAKN
661
FHFHD
666
WKCVP
671
ACGEG
676
FYPEE
681
MPGLP
686
HKVCR
691
RCDEN
696
CLSCA
701
GSSRN
706
CSRCK
711
TGFTQ
716
LGTSC
721
ITNHT
726
CSNAD
731
ETFCE
736
MVKSN
741
RLCER
746
KLFIQ
751
FCCRT
756
CLLAG
761
Mutation Information
DNA mutation:
None
Peptide Range:
149 ~ 173
Mut AA position:
161 (13 in Wild Type peptide)
Alignment
Wild Type:
"LDGDVTDVVEAKSLGIRPNYIDIYS
||||||||||||.||||||||||||
Mutant:
LDGDVTDVVEAKLLGIRPNYIDIYS"
reference

Science, 2015

Immunogenicity of somatic mutations in human gastrointestinal cancers

Gene Name (from Reference) PCSK6

clinic trial
Checkpoint Blockade

None

ACT

None

Vaccination

None

Curative Effect

None

experiment
minimal_peptide

None

Antigen Type

TMG RNA

T-cell Source

TILs

APC Type

autologous DCs

Assay

IFNg ELISPOT assay