Immunogenicity 3055

summary
Sample ID
3942
Response
Negative
Tumor Type
Rectal cancer
Gene Symbol
ZKSCAN2
Transcript ID
uc002dod.4
HLA INFO
DQA*02:01 / DQB*02:02
TCR INFO

No TCR info found!

T cell Tumor cell { DQA*02:01 DQB*02:02
sequence
Full length protein sequence (967 aa)
MAVAL
1
DSQID
6
APLEV
11
EGCLI
16
MKVEK
21
DPEWA
26
SEPIL
31
EGSDS
36
SETFR
41
KCFRQ
46
FCYED
51
VTGPH
56
EAFSK
61
LWELC
66
CRWLK
71
PEMRS
76
KEQIL
81
ELLVI
86
EQFLT
91
ILPEK
96
IQAWA
101
QKQCP
106
QSGEE
111
AVALV
116
VHLEK
121
ETGRL
126
RQQVS
131
SPVHR
136
EKHSP
141
LGAAW
146
EVADF
151
QPEQV
156
ETQPR
161
AVSRE
166
EPGSL
171
HSGHQ
176
EQLNR
181
KRERR
186
PLPKN
191
ARPSP
196
WVPAL
201
ADEWN
206
TLDQE
211
VTTTR
216
LPAGS
221
QEPVK
226
DVHVA
231
RGFSY
236
RKSVH
241
QIPAQ
246
RDLYR
251
DFRKE
256
NVGNV
261
VSLGS
266
AVSTS
271
NKITR
276
LEQRK
281
EPWTL
286
GLHSS
291
NKRSI
296
LRSNY
301
VKEKS
306
VHAIQ
311
VPARS
316
AGKTW
321
REQQQ
326
WGLED
331
EKIAG
336
VHWSY
341
EETKT
346
FLAIL
351
KESRF
356
YETLQ
361
ACPRN
366
SQVYG
371
AVAEW
376
LRECG
381
FLRTP
386
EQCRT
391
KFKSL
396
QKSYR
401
KVRNG
406
HMLEP
411
CAFFE
416
DMDAL
421
LNPAA
426
RAPST
431
DKPKE
436
MIPVP
441
RLKRI
446
AISAK
451
EHISL
456
VEEEE
461
AAEDS
466
DDDEI
471
GIEFI
476
RKSEI
481
HGAPV
486
LFQNL
491
SGVHW
496
GYEET
501
KTFLD
506
ILRET
511
RFYEA
516
LQACH
521
RKSKL
526
YGAVA
531
EQLRE
536
CGFLR
541
TPEQC
546
RTKFK
551
SLQKS
556
YRKVK
561
NGHVL
566
ESCAF
571
YKEMD
576
ALINS
581
RASAP
586
SPSTP
591
EEVPS
596
PSRQE
601
RGGIE
606
VEPQE
611
PTGWE
616
PEETS
621
QEAVI
626
EDSCS
631
ERMSE
636
EEIVQ
641
EPEFQ
646
GPPGL
651
LQSPN
656
DFEIG
661
SSIKE
666
DPTQI
671
VYKDM
676
EQHRA
681
LIEKS
686
KRVVS
691
QSTDP
696
SKYRK
701
RECIS
706
GRQWE
711
NLQGI
716
RQGKP
721
MSQPR
726
DLGKA
731
VVHQR
736
PFVGK
741
RPYRL
746
LKYGE
751
SFGRS
756
TRLMC
761
RMTHH
766
KENPY
771
KCGVC
776
GKCFG
781
RSRSL
786
IRHQR
791
IHTGE
796
KPFKC
801
LDCGK
806
SFNDS
811
SNFGA
816
HQRIH
821
TGEKP
826
YRCGE
831
CGKCF
836
SQSSS
841
LIIHQ
846
RTHTG
851
EKPYQ
856
CGECG
861
KSFTN
866
SSHFS
871
AHRRV
876
HTGEN
881
PYKCV
886
DCEKS
891
FNNCT
896
RFREH
901
RRIHT
906
GEKPY
911
GCAQC
916
GKRFS
921
KSSVL
926
TKHRE
931
VHVRE
936
KPLPH
941
PPSLY
946
CPENP
951
HKGKT
956
DEFRK
961
TF
966
Mutation Information
DNA mutation:
None
Peptide Range:
844 ~ 868
Mut AA position:
856 (13 in Wild Type peptide)
Alignment
Wild Type:
"SSLIIHQRTHTGEKPYQCGECGKSF
||||||||||||.||||||||||||
Mutant:
SSLIIHQRTHTGKKPYQCGECGKSF"
reference

Science, 2015

Immunogenicity of somatic mutations in human gastrointestinal cancers

Gene Name (from Reference) ZKSCAN2

clinic trial
Checkpoint Blockade

None

ACT

None

Vaccination

None

Curative Effect

None

experiment
minimal_peptide

None

Antigen Type

TMG RNA

T-cell Source

TILs

APC Type

autologous DCs

Assay

IFNg ELISPOT assay