Immunogenicity 3237
Sample ID
4032
Response
Negative
Tumor Type
Colon cancer
Gene Symbol
CACNA1A
Transcript ID
uc010xne.2
HLA INFO
B*13:02
TCR INFO
No TCR info found!
Full length protein sequence (2512 aa)
MARFG
1
DEMPA
6
RYGGG
11
GSGAA
16
AGVVV
21
GSGGG
26
RGAGG
31
SRQGG
36
QPGAQ
41
RMYKQ
46
SMAQR
51
ARTMA
56
LYNPI
61
PVRQN
66
CLTVN
71
RSLFL
76
FSEDN
81
VVRKY
86
AKKIT
91
EWPPF
96
EYMIL
101
ATIIA
106
NCIVL
111
ALEQH
116
LPDDD
121
KTPMS
126
ERLDD
131
TEPYF
136
IGIFC
141
FEAGI
146
KIIAL
151
GFAFH
156
KGSYL
161
RNGWN
166
VMDFV
171
VVLTG
176
ILATV
181
GTEFD
186
LRTLR
191
AVRVL
196
RPLKL
201
VSGIP
206
SLQVV
211
LKSIM
216
KAMIP
221
LLQIG
226
LLLFF
231
AILIF
236
AIIGL
241
EFYMG
246
KFHTT
251
CFEEG
256
TDDIQ
261
GESPA
266
PCGTE
271
EPART
276
CPNGT
281
KCQPY
286
WEGPN
291
NGITQ
296
FDNIL
301
FAVLT
306
VFQCI
311
TMEGW
316
TDLLY
321
NSNDA
326
SGNTW
331
NWLYF
336
IPLII
341
IGSFF
346
MLNLV
351
LGVLS
356
GEFAK
361
ERERV
366
ENRRA
371
FLKLR
376
RQQQI
381
ERELN
386
GYMEW
391
ISKAE
396
EVILA
401
EDETD
406
GEQRH
411
PFDGA
416
LRRTT
421
IKKSK
426
TDLLN
431
PEEAE
436
DQLAD
441
IASVG
446
SPFAR
451
ASIKS
456
AKLEN
461
STFFH
466
KKERR
471
MRFYI
476
RRMVK
481
TQAFY
486
WTVLS
491
LVALN
496
TLCVA
501
IVHYN
506
QPEWL
511
SDFLY
516
YAEFI
521
FLGLF
526
MSEMF
531
IKMYG
536
LGTRP
541
YFHSS
546
FNCFD
551
CGVII
556
GSIFE
561
VIWAV
566
IKPGT
571
SFGIS
576
VLRAL
581
RLLRI
586
FKVTK
591
YWASL
596
RNLVV
601
SLLNS
606
MKSII
611
SLLFL
616
LFLFI
621
VVFAL
626
LGMQL
631
FGGQF
636
NFDEG
641
TPPTN
646
FDTFP
651
AAIMT
656
VFQIL
661
TGEDW
666
NEVMY
671
DGIKS
676
QGGVQ
681
GGMVF
686
SIYFI
691
VLTLF
696
GNYTL
701
LNVFL
706
AIAVD
711
NLANA
716
QELTK
721
VEADE
726
QEEEE
731
AANQK
736
LALQK
741
AKEVA
746
EVSPL
751
SAANM
756
SIAVK
761
EQQKN
766
QKPAK
771
SVWEQ
776
RTSEM
781
RKQNL
786
LASRE
791
ALYNE
796
MDPDE
801
RWKAA
806
YTRHL
811
RPDMK
816
THLDR
821
PLVVD
826
PQENR
831
NNNTN
836
KSRAA
841
EPTVD
846
QRLGQ
851
QRAED
856
FLRKQ
861
ARYHD
866
RARDP
871
SGSAG
876
LDARR
881
PWAGS
886
QEAEL
891
SREGP
896
YGRES
901
DHHAR
906
EGSLE
911
QPGFW
916
EGEAE
921
RGKAG
926
DPHRR
931
HVHRQ
936
GGSRE
941
SRSGS
946
PRTGA
951
DGEHR
956
RHRAH
961
RRPGE
966
EGPED
971
KAERR
976
ARHRE
981
GSRPA
986
RGGEG
991
EGEGP
996
DGGER
1001
RRRHR
1006
HGAPA
1011
TYEGD
1016
ARRED
1021
KERRH
1026
RRRKE
1031
NQGSG
1036
VPVSG
1041
PNLST
1046
TRPIQ
1051
QDLGR
1056
QDPPL
1061
AEDID
1066
NMKNN
1071
KLATA
1076
ESAAP
1081
HGSLG
1086
HAGLP
1091
QSPAK
1096
MGNST
1101
DPGPM
1106
LAIPA
1111
MATNP
1116
QNAAS
1121
RRTPN
1126
NPGNP
1131
SNPGP
1136
PKTPE
1141
NSLIV
1146
TNPSG
1151
TQTNS
1156
AKTAR
1161
KPDHT
1166
TVDIP
1171
PACPP
1176
PLNHT
1181
VVQVN
1186
KNANP
1191
DPLPK
1196
KEEEK
1201
KEEEE
1206
DDRGE
1211
DGPKP
1216
MPPYS
1221
SMFIL
1226
STTNP
1231
LRRLC
1236
HYILN
1241
LRYFE
1246
MCILM
1251
VIAMS
1256
SIALA
1261
AEDPV
1266
QPNAP
1271
RNNVL
1276
RYFDY
1281
VFTGV
1286
FTFEM
1291
VIKMI
1296
DLGLV
1301
LHQGA
1306
YFRDL
1311
WNILD
1316
FIVVS
1321
GALVA
1326
FAFTG
1331
NSKGK
1336
DINTI
1341
KSLRV
1346
LRVLR
1351
PLKTI
1356
KRLPK
1361
LKAVF
1366
DCVVN
1371
SLKNV
1376
FNILI
1381
VYMLF
1386
MFIFA
1391
VVAVQ
1396
LFKGK
1401
FFHCT
1406
DESKE
1411
FEKDC
1416
RGKYL
1421
LYEKN
1426
EVKAR
1431
DREWK
1436
KYEFH
1441
YDNVL
1446
WALLT
1451
LFTVS
1456
TGEGW
1461
PQVLK
1466
HSVDA
1471
TFENQ
1476
GPSPG
1481
YRMEM
1486
SIFYV
1491
VYFVV
1496
FPFFF
1501
VNIFV
1506
ALIII
1511
TFQEQ
1516
GDKMM
1521
EEYSL
1526
EKNER
1531
ACIDF
1536
AISAK
1541
PLTRH
1546
MPQNK
1551
QSFQY
1556
RMWQF
1561
VVSPP
1566
FEYTI
1571
MAMIA
1576
LNTIV
1581
LMMKF
1586
YGASV
1591
AYENA
1596
LRVFN
1601
IVFTS
1606
LFSLE
1611
CVLKV
1616
MAFGI
1621
LNYFR
1626
DAWNI
1631
FDFVT
1636
VLGSI
1641
TDILV
1646
TEFGN
1651
PNNFI
1656
NLSFL
1661
RLFRA
1666
ARLIK
1671
LLRQG
1676
YTIRI
1681
LLWTF
1686
VQSFK
1691
ALPYV
1696
CLLIA
1701
MLFFI
1706
YAIIG
1711
MQVFG
1716
NIGID
1721
VEDED
1726
SDEDE
1731
FQITE
1736
HNNFR
1741
TFFQA
1746
LMLLF
1751
RSATG
1756
EAWHN
1761
IMLSC
1766
LSGKP
1771
CDKNS
1776
GILTR
1781
ECGNE
1786
FAYFY
1791
FVSFI
1796
FLCSF
1801
LMLNL
1806
FVAVI
1811
MDNFE
1816
YLTRD
1821
SSILG
1826
PHHLD
1831
EYVRV
1836
WAEYD
1841
PAAWG
1846
RMPYL
1851
DMYQM
1856
LRHMS
1861
PPLGL
1866
GKKCP
1871
ARVAY
1876
KRLLR
1881
MDLPV
1886
ADDNT
1891
VHFNS
1896
TLMAL
1901
IRTAL
1906
DIKIA
1911
KGGAD
1916
KQQMD
1921
AELRK
1926
EMMAI
1931
WPNLS
1936
QKTLD
1941
LLVTP
1946
HKSTD
1951
LTVGK
1956
IYAAM
1961
MIMEY
1966
YRQSK
1971
AKKLQ
1976
AMREE
1981
QDRTP
1986
LMFQR
1991
MEPPS
1996
PTQEG
2001
GPGQN
2006
ALPST
2011
QLDPG
2016
GALMA
2021
HESGL
2026
KESPS
2031
WVTQR
2036
AQEMF
2041
QKTGT
2046
WSPEQ
2051
GPPTD
2056
MPNSQ
2061
PNSQS
2066
VEMRE
2071
MGRDG
2076
YSDSE
2081
HYLPM
2086
EGQGR
2091
AASMP
2096
RLPAE
2101
NQRRR
2106
GRPRG
2111
NNLST
2116
ISDTS
2121
PMKRS
2126
ASVLG
2131
PKARR
2136
LDDYS
2141
LERVP
2146
PEENQ
2151
RHHQR
2156
RRDRS
2161
HRASE
2166
RSLGR
2171
YTDVD
2176
TGLGT
2181
DLSMT
2186
TQSGD
2191
LPSKE
2196
RDQER
2201
GRPKD
2206
RKHRQ
2211
HHHHH
2216
HHHHH
2221
PPPPD
2226
KDRYA
2231
QERPD
2236
HGRAR
2241
ARDQR
2246
WSRSP
2251
SEGRE
2256
HMAHR
2261
QGSSS
2266
VSGSP
2271
APSTS
2276
GTSTP
2281
RRGRR
2286
QLPQT
2291
PSTPR
2296
PHVSY
2301
SPVIR
2306
KAGGS
2311
GPPQQ
2316
QQQQQ
2321
QQQQQ
2326
QAVAR
2331
PGRAA
2336
TSGPR
2341
RYPGP
2346
TAEPL
2351
AGDRP
2356
PTGGH
2361
SSGRS
2366
PRMER
2371
RVPGP
2376
ARSES
2381
PRACR
2386
HGGAR
2391
WPASG
2396
PHVSE
2401
GPPGP
2406
RHHGY
2411
YRGSD
2416
YDEAD
2421
GPGSG
2426
GGEEA
2431
MAGAY
2436
DAPPP
2441
VRHAS
2446
SGATG
2451
RSPRT
2456
PRASG
2461
PACAS
2466
PSRHG
2471
RRLPN
2476
GYYPA
2481
HGLAR
2486
PRGPG
2491
SRKGL
2496
HEPYS
2501
ESDDD
2506
WC
2511
Mutation Information
DNA mutation:
None
Peptide Range:
2279 ~ 2309
Mut AA position:
2291 (13 in Wild Type peptide)
Alignment
Wild Type:
"TSGTSTPRRGRRQLPQTPSTPRPHV------
||||||||||||.|||||.||||||
Mutant:
TSGTSTPRRGRRPLPQTPPTPRPHVSYSPVI"
Science, 2015
Immunogenicity of somatic mutations in human gastrointestinal cancersGene Name (from Reference) CACNA1A
Checkpoint
Blockade
None
ACT
None
Vaccination
None
Curative
Effect
None
minimal_peptide
None
Antigen
Type
TMG RNA
T-cell
Source
TILs
APC
Type
autologous DCs
Assay
IFNg ELISPOT assay