Immunogenicity 3294
Sample ID
4069
Response
Negative
Tumor Type
Pancreatic cancer
Gene Symbol
KMT2B
Transcript ID
uc021usv.1
HLA INFO
DRB*04:02
TCR INFO
No TCR info found!
Full length protein sequence (2715 aa)
MAAAA
1
GGGSC
6
PGPGS
11
ARGRF
16
PGRPR
21
GAGGG
26
GGRGG
31
RGNGA
36
ERVRV
41
ALRRG
46
GGATG
51
PGGAE
56
PGEDT
61
ALLRL
66
LGLRR
71
GLRRL
76
RRLWA
81
GPRVQ
86
RGRGR
91
GRGRG
96
WGPSR
101
GCVPE
106
EESSD
111
GESDE
116
EEFQG
121
FHSDE
126
DVAPS
131
SLRSA
136
LRSQR
141
GRAPR
146
GRGRK
151
HKTTP
156
LPPPR
161
LADVA
166
PTPPK
171
TPARK
176
RGEEG
181
TERMV
186
QALTE
191
LLRRA
196
QAPQA
201
PRSRA
206
CEPST
211
PRRSR
216
GRPPG
221
RPAGP
226
CRRKQ
231
QAVVV
236
AEAAV
241
TIPKP
246
EPPPP
251
VVPVK
256
HQTGS
261
WKCKE
266
GPGPG
271
PGTPR
276
RGGQS
281
SRGGR
286
GGRGR
291
GRGGG
296
LPFVI
301
KFVSR
306
AKKVK
311
MGQLS
316
LGLES
321
GQGQG
326
QHEES
331
WQDVP
336
QRRVG
341
SGQGG
346
SPCWK
351
KQEQK
356
LDDEE
361
EEKKE
366
EEEKD
371
KEGEE
376
KEERA
381
VAEEM
386
MPAAE
391
KEEAK
396
LPPPP
401
LTPPA
406
PSPPP
411
PLPPP
416
STSPP
421
PPLCP
426
PPPPP
431
VSPPP
436
LPSPP
441
PPPAQ
446
EEQEE
451
SPPPV
456
VPATC
461
SRKRG
466
RPPLT
471
PSQRA
476
EREAA
481
RAGPE
486
GTSPP
491
TPTPS
496
TATGG
501
PPEDS
506
PTVAP
511
KSTTF
516
LKNIR
521
QFIMP
526
VVSAR
531
SSRVI
536
KTPRR
541
FMDED
546
PPKPP
551
KVEVS
556
PVLRP
561
PITTS
566
PPVPQ
571
EPAPV
576
PSPPR
581
APTPP
586
STPVP
591
LPEKR
596
RSILR
601
EPTFR
606
WTSLT
611
RELPP
616
PPPAP
621
PPPPA
626
PSPPP
631
APATS
636
SRRPL
641
LLRAP
646
QFTPS
651
EAHLK
656
IYESV
661
LTPPP
666
LGAPE
671
APEPE
676
PPPAD
681
DSPAE
686
PEPRA
691
VGRTN
696
HLSLP
701
RFAPV
706
VTTPV
711
KAEVS
716
PHGAP
721
ALSNG
726
PQTQA
731
QLLQP
736
LQALQ
741
TQLLP
746
QALPP
751
PQPQL
756
QPPPS
761
PQQMP
766
PLEKA
771
RIAGV
776
GSLPL
781
SGVEE
786
KMFSL
791
LKRAK
796
VQLFK
801
IDQQQ
806
QQKVA
811
ASMPL
816
SPGGQ
821
MEEVA
826
GAVKQ
831
ISDRG
836
PVRSE
841
DESVE
846
AKRER
851
PSGPE
856
SPVQG
861
PRIKH
866
VCRHA
871
AVALG
876
QARAM
881
VPEDV
886
PRLSA
891
LPLRD
896
RQDLA
901
TEDTS
906
SASET
911
ESVPS
916
RSRRG
921
KVEAA
926
GPGGE
931
SEPTG
936
SGGTL
941
AHTPR
946
RSLPS
951
HHGKK
956
MRMAR
961
CGHCR
966
GCLRV
971
QDCGS
976
CVNCL
981
DKPKF
986
GGPNT
991
KKQCC
996
VYRKC
1001
DKIEA
1006
RKMER
1011
LAKKG
1016
RTIVK
1021
TLLPW
1026
DSDES
1031
PEASP
1036
GPPGP
1041
RRGAG
1046
AGGPR
1051
EEVVA
1056
HPGPE
1061
EQDSL
1066
LQRKS
1071
ARRCV
1076
KQRPS
1081
YDIFE
1086
DSDDS
1091
EPGGP
1096
PAPRR
1101
RTPRE
1106
NELPL
1111
PEPEE
1116
QSRPR
1121
KPTLQ
1126
PVLQL
1131
KARRR
1136
LDKDA
1141
LAPGP
1146
FASFP
1151
NGWTG
1156
KQKSP
1161
DGVHR
1166
VRVDF
1171
KEDCD
1176
LENVW
1181
LMGGL
1186
SVLTS
1191
VPGGP
1196
PMVCL
1201
LCASK
1206
GLHEL
1211
VFCQV
1216
CCDPF
1221
HPFCL
1226
EEAER
1231
PLPQH
1236
HDTWC
1241
CRRCK
1246
FCHVC
1251
GRKGR
1256
GSKHL
1261
LECER
1266
CRHAY
1271
HPACL
1276
GPSYP
1281
TRATR
1286
KRRHW
1291
ICSAC
1296
VRCKS
1301
CGATP
1306
GKNWD
1311
VEWSG
1316
DYSLC
1321
PRCTQ
1326
LYEKG
1331
NYCPI
1336
CTRCY
1341
EDNDY
1346
ESKMM
1351
QCAQC
1356
DHWVH
1361
AKCEG
1366
LSDED
1371
YEILS
1376
GLPDS
1381
VLYTC
1386
GPCAG
1391
AAQPR
1396
WREAL
1401
SGALQ
1406
GGLRQ
1411
VLQGL
1416
LSSKV
1421
VGPLL
1426
LCTQC
1431
GPDGK
1436
QLHPG
1441
PCGLQ
1446
AVSQR
1451
FEDGH
1456
YKSVH
1461
SFMED
1466
MVGIL
1471
MRHSE
1476
EGETP
1481
DRRAG
1486
GQMKG
1491
LLLKL
1496
LESAF
1501
GWFDA
1506
HDPKY
1511
WRRST
1516
RLPNG
1521
VLPNA
1526
VLPPS
1531
LDHVY
1536
AQWRQ
1541
QEPET
1546
PESGQ
1551
PPGDP
1556
SAAFQ
1561
GKDPA
1566
AFSHL
1571
EDPRQ
1576
CALCL
1581
KYGDA
1586
DSKEA
1591
GRLLY
1596
IGQNE
1601
WTHVN
1606
CAIWS
1611
AEVFE
1616
ENDGS
1621
LKNVH
1626
AAVAR
1631
GRQMR
1636
CELCL
1641
KPGAT
1646
VGCCL
1651
SSCLS
1656
NFHFM
1661
CARAS
1666
YCIFQ
1671
DDKKV
1676
FCQKH
1681
TDLLD
1686
GKEIV
1691
NPDGF
1696
DVLRR
1701
VYVDF
1706
EGINF
1711
KRKFL
1716
TGLEP
1721
DAINV
1726
LIGSI
1731
RIDSL
1736
GTLSD
1741
LSDCE
1746
GRLFP
1751
IGYQC
1756
SRLYW
1761
STVDA
1766
RRRCW
1771
YRCRI
1776
LEYRP
1781
WGPRE
1786
EPAHL
1791
EAAEE
1796
NQTIV
1801
HSPAP
1806
SSEPP
1811
GGEDP
1816
PLDTD
1821
VLVPG
1826
APERH
1831
SPIQN
1836
LDPPL
1841
RPDSG
1846
SAPPP
1851
APRSF
1856
SGARI
1861
KVPNY
1866
SPSRR
1871
PLGGV
1876
SFGPL
1881
PSPGS
1886
PSSLT
1891
HHIPT
1896
VGDPD
1901
FPAPP
1906
RRSRR
1911
PSPLA
1916
PRPPP
1921
SRWAS
1926
PPLKT
1931
SPQLR
1936
VPPPT
1941
SVVTA
1946
LTPTS
1951
GELAP
1956
PGPAP
1961
SPPPP
1966
EDLGP
1971
DFEDM
1976
EVVSG
1981
LSAAD
1986
LDFAA
1991
SLLGT
1996
EPFQE
2001
EIVAA
2006
GAMGS
2011
SHGGP
2016
GDSSE
2021
EESSP
2026
TSRYI
2031
HFPVT
2036
VVSAP
2041
GLAPS
2046
ATPGA
2051
PRIEQ
2056
LDGVD
2061
DGTDS
2066
EAEAV
2071
QQPRG
2076
QGTPP
2081
SGPGV
2086
VRAGV
2091
LGAAG
2096
DRARP
2101
PEDLP
2106
SEIVD
2111
FVLKN
2116
LGGPG
2121
DGGAG
2126
PREES
2131
LPPAP
2136
PLANG
2141
SQPSQ
2146
GLTAS
2151
PADPT
2156
RTFAW
2161
LPGAP
2166
GVRVL
2171
SLGPA
2176
PEPPK
2181
PATSK
2186
IILVN
2191
KLGQV
2196
FVKMA
2201
GEGEP
2206
VPPPV
2211
KQPPL
2216
PPTIS
2221
PTAPT
2226
SWTLP
2231
PGPLL
2236
GVLPV
2241
VGVVR
2246
PAPPP
2251
PPPPL
2256
TLVLS
2261
SGPAS
2266
PPRQA
2271
IRVKR
2276
VSTFS
2281
GRSPP
2286
APPPY
2291
KAPRL
2296
DEDGE
2301
ASEDT
2306
PQVPG
2311
LGSGG
2316
FSRVR
2321
MKTPT
2326
VRGVL
2331
DLDRP
2336
GEPAG
2341
EESPG
2346
PLQER
2351
SPLLP
2356
LPEDG
2361
PPQVP
2366
DGPPD
2371
LLLES
2376
QWHHY
2381
SGEAS
2386
SSEEE
2391
PPSPD
2396
DKENQ
2401
APKRT
2406
GPHLR
2411
FEISS
2416
EDGFS
2421
VEAES
2426
LEGAW
2431
RTLIE
2436
KVQEA
2441
RGHAR
2446
LRHLS
2451
FSGMS
2456
GARLL
2461
GIHHD
2466
AVIFL
2471
AEQLP
2476
GAQRC
2481
QHYKF
2486
RYHQQ
2491
GEGQE
2496
EPPLN
2501
PHGAA
2506
RAEVY
2511
LRKCT
2516
FDMFN
2521
FLASQ
2526
HRVLP
2531
EGATC
2536
DEEED
2541
EVQLR
2546
STRRA
2551
TSLEL
2556
PMAMR
2561
FRHLK
2566
KTSKE
2571
AVGVY
2576
RSAIH
2581
GRGLF
2586
CKRNI
2591
DAGEM
2596
VIEYS
2601
GIVIR
2606
SVLTD
2611
KREKF
2616
YDGKG
2621
IGCYM
2626
FRMDD
2631
FDVVD
2636
ATMHG
2641
NAARF
2646
INHSC
2651
EPNCF
2656
SRVIH
2661
VEGQK
2666
HIVIF
2671
ALRRI
2676
LRGEE
2681
LTYDY
2686
KFPIE
2691
DASNK
2696
LPCNC
2701
GAKRC
2706
RRFLN
2711
Mutation Information
DNA mutation:
None
Peptide Range:
486 ~ 510
Mut AA position:
498 (13 in Wild Type peptide)
Alignment
Wild Type:
"RAGPEGTSPPTPTPSTATGGPPEDS
||||||||||||.||||||||||||
Mutant:
RAGPEGTSPPTPPPSTATGGPPEDS"
Science, 2015
Immunogenicity of somatic mutations in human gastrointestinal cancersGene Name (from Reference) KMT2B
Checkpoint
Blockade
None
ACT
None
Vaccination
None
Curative
Effect
None
minimal_peptide
None
Antigen
Type
TMG RNA
T-cell
Source
TILs
APC
Type
autologous DCs
Assay
IFNg ELISPOT assay