Immunogenicity 3371

summary
Sample ID
4069
Response
Negative
Tumor Type
Pancreatic cancer
Gene Symbol
ASXL2
Transcript ID
uc002rgt.1
HLA INFO
C*12:02
TCR INFO

No TCR info found!

T cell Tumor cell C*12:02
sequence
Full length protein sequence (918 aa)
MKRTK
1
CADID
6
VETPD
11
SILVN
16
TNLRA
21
LINKH
26
TFSVL
31
PGDCQ
36
QRLLL
41
LLPEV
46
DRQVG
51
PDGLM
56
KLNGS
61
ALNNE
66
FFTSA
71
AQGWK
76
ERLSE
81
GEFTP
86
EMQVR
91
IRQEI
96
EKEKK
101
VEPWK
106
EQFFE
111
SYYGQ
116
SSGLS
121
LEDSK
126
KLTAS
131
PSDPK
136
VKKTP
141
AEQPK
146
SMPVS
151
EASLI
156
RIVPV
161
VSQSE
166
CKEEA
171
LQMSS
176
PGRKE
181
ECESQ
186
GEVQP
191
NFSTS
196
SEPLL
201
SSALN
206
THELS
211
SILPI
216
KCPKD
221
EDLLE
226
QKPVT
231
SAEQE
236
SEKNH
241
LTTAS
246
NYNKS
251
ESQES
256
LVTSP
261
SKPKS
266
PGVEK
271
PIVKP
276
TAGAG
281
PQETN
286
MKEPL
291
ATLVD
296
QSPES
301
LKRKS
306
SLTQE
311
EAPVS
316
WEKRP
321
RVTEN
326
RQHQQ
331
PFQVS
336
PQPFL
341
NRGDR
346
IQVRK
351
VPPLK
356
IPVSR
361
ISPMP
366
FHPSQ
371
VSPRA
376
RFPVS
381
ITSPN
386
RTGAR
391
TLADI
396
KAKAQ
401
LVKAQ
406
RAAAA
411
AAAAA
416
AAAAS
421
VGGTI
426
PGPGP
431
GGGQG
436
PGEGG
441
EGQTA
446
RGGSP
451
GSDRV
456
SETGK
461
GPTLE
466
LAGTG
471
SRGGT
476
RELLP
481
CGPET
486
QPQSE
491
TKTTP
496
SQAQP
501
HSVSG
506
AQLQQ
511
TPPVP
516
PTPAV
521
SGACT
526
SVPSP
531
AHIEK
536
LDNEK
541
LNPTR
546
ATATV
551
ASVSH
556
PQGPS
561
SCRQE
566
KAPSP
571
TGFQL
576
EDIST
581
SQRFM
586
LGFAG
591
RRTSK
596
PAMAG
601
HYLLN
606
ISTYG
611
RGSES
616
FRRTH
621
SVNPE
626
DRFCL
631
SSPTE
636
ALKMG
641
YTDCK
646
NATGE
651
SSSSK
656
EDDTD
661
EESTG
666
DEQES
671
VTVKE
676
EPQVS
681
QSAGK
686
GDTSS
691
GPHSR
696
ETLST
701
SDCLA
706
SKNVK
711
AEIPL
716
NEQTT
721
LSKEN
726
YLFTR
731
GQTFD
736
EKTLA
741
RDLIQ
746
AAQKQ
751
MAHAV
756
RGKAI
761
RSSPE
766
LFSST
771
VLPLP
776
ADSPT
781
HQPLL
786
LPPLQ
791
TPKLY
796
GSPTQ
801
IGPSY
806
RGMIN
811
VSTSS
816
DMDHN
821
SAVPG
826
SQVSS
831
NVGDV
836
MSFSV
841
TVTTI
846
PASQA
851
MNPSS
856
HGQTI
861
PVQAF
866
SEENS
871
IEGTP
876
SKCYC
881
RLKAM
886
IMCKG
891
CGAFC
896
HDDCI
901
GPSKL
906
CVSCL
911
VVR
916
Mutation Information
DNA mutation:
None
Peptide Range:
306 ~ 330
Mut AA position:
318 (13 in Wild Type peptide)
Alignment
Wild Type:
"LKRKSSLTQEEAPVSWEKRPRVTEN
||||||||||||.||||||||||||
Mutant:
LKRKSSLTQEEAHVSWEKRPRVTEN"
reference

Science, 2015

Immunogenicity of somatic mutations in human gastrointestinal cancers

Gene Name (from Reference) ASXL2

clinic trial
Checkpoint Blockade

None

ACT

None

Vaccination

None

Curative Effect

None

experiment
minimal_peptide

None

Antigen Type

TMG RNA

T-cell Source

TILs

APC Type

autologous DCs

Assay

IFNg ELISPOT assay