Immunogenicity 3460

summary
Sample ID
3942
Response
Negative
Tumor Type
Rectal cancer
Gene Symbol
GDF5
Transcript ID
uc010gfc.1
HLA INFO
C*16:01
TCR INFO

No TCR info found!

T cell Tumor cell C*16:01
sequence
Full length protein sequence (505 aa)
MRLPK
1
LLTFL
6
LWYLA
11
WLDLE
16
FICTV
21
LGAPD
26
LGQRP
31
QGTRP
36
GLAKA
41
EAKER
46
PPLAR
51
NVFRP
56
GGHSY
61
GGGAT
66
NANAR
71
AKGGT
76
GQTGG
81
LTQPK
86
KDEPK
91
KLPPR
96
PGGPE
101
PKPGH
106
PPQTR
111
QATAR
116
TVTPK
121
GQLPG
126
GKAPP
131
KAGSV
136
PSSFL
141
LKKAR
146
EPGPP
151
REPKE
156
PFRPP
161
PITPH
166
EYMLS
171
LYRTL
176
SDADR
181
KGGNS
186
SVKLE
191
AGLAN
196
TITSF
201
IDKGQ
206
DDRGP
211
VVRKQ
216
RYVFD
221
ISALE
226
KDGLL
231
GAELR
236
ILRKK
241
PSDTA
246
KPAAP
251
GGGRA
256
AQLKL
261
SSCPS
266
GRQPA
271
SLLDV
276
RSVPG
281
LDGSG
286
WEVFD
291
IWKLF
296
RNFKN
301
SAQLC
306
LELEA
311
WERGR
316
AVDLR
321
GLGFD
326
RAARQ
331
VHEKA
336
LFLVF
341
GRTKK
346
RDLFF
351
NEIKA
356
RSGQD
361
DKTVY
366
EYLFS
371
QRRKR
376
RAPLA
381
TRQGK
386
RPSKN
391
LKARC
396
SRKAL
401
HVNFK
406
DMGWD
411
DWIIA
416
PLEYE
421
AFHCE
426
GLCEF
431
PLRSH
436
LEPTN
441
HAVIQ
446
TLMNS
451
MDPES
456
TPPTC
461
CVPTR
466
LSPIS
471
ILFID
476
SANNV
481
VYKQY
486
EDMVV
491
ESCGC
496
SDPPS
501
Mutation Information
DNA mutation:
None
Peptide Range:
250 ~ 274
Mut AA position:
262 (13 in Wild Type peptide)
Alignment
Wild Type:
"AKPAAPGGGRAAQLKLSSCPSGRQP
||||||||||||.||||||||||||
Mutant:
AKPAAPGGGRAARLKLSSCPSGRQP"
reference

Science, 2015

Immunogenicity of somatic mutations in human gastrointestinal cancers

Gene Name (from Reference) GDF5

clinic trial
Checkpoint Blockade

None

ACT

None

Vaccination

None

Curative Effect

None

experiment
minimal_peptide

None

Antigen Type

TMG RNA

T-cell Source

TILs

APC Type

autologous DCs

Assay

IFNg ELISPOT assay