Immunogenicity 3519

summary
Sample ID
3942
Response
Negative
Tumor Type
Rectal cancer
Gene Symbol
HIRA
Transcript ID
uc010grn.1
HLA INFO
DRB*07:01
TCR INFO

No TCR info found!

T cell Tumor cell DRB*07:01
sequence
Full length protein sequence (810 aa)
MKLLK
1
PTWVN
6
HNGKP
11
IFSVD
16
IHPDG
21
TKFAT
26
GGQGQ
31
DSGKV
36
VIWNM
41
SPVLQ
46
EDDEK
51
DENIP
56
KMLCQ
61
MDNHL
66
ACVNC
71
VRWSN
76
SGMYL
81
ASGGD
86
DKLIM
91
VWKRA
96
TYIGP
101
STVFG
106
SSGKL
111
ANVEQ
116
WRCVS
121
ILRNH
126
SGDVM
131
DVAWS
136
PHDAW
141
LASCS
146
VDNTV
151
VIWNA
156
VKFPE
161
ILATL
166
RGHSG
171
LVKGL
176
TWDPV
181
GKYIA
186
SQADD
191
RSLKV
196
WRTLD
201
WQLET
206
SITKP
211
FDECG
216
GTTHV
221
LRLSW
226
SPDGH
231
YLVSA
236
HAMNN
241
SGPTA
246
QIIER
251
EGWKT
256
NMDFV
261
GHRKA
266
VTVVK
271
FNPKI
276
FKKKQ
281
KNGSS
286
AKPSC
291
PYCCC
296
AVGSK
301
DRSLS
306
VWLTC
311
LKRPL
316
VVIHE
321
LFDKS
326
IMDIS
331
WTLNG
336
LGILV
341
CSMDG
346
SVAFL
351
DFSQD
356
ELGDP
361
LSEEE
366
KSRIH
371
QSTYG
376
KSLAI
381
MTEAQ
386
LSTAV
391
IENPE
396
MLKYQ
401
RRQQQ
406
QQLDQ
411
KSAAT
416
REMGS
421
ATSVA
426
GVVNG
431
ESLED
436
IRKNL
441
LKKQV
446
ETRTA
451
DGRRR
456
ITPLC
461
IAQLD
466
TGDFS
471
TAFFN
476
SIPLS
481
GSLAG
486
TMLSS
491
HSSPQ
496
LLPLD
501
SSTPN
506
SFGAS
511
KPCTE
516
PVVAA
521
SARPA
526
GDSVN
531
KDSMN
536
ATSTP
541
AALSP
546
SVLTT
551
PSKIE
556
PMKAF
561
DSRFT
566
ERSKA
571
TPGAP
576
ALTSM
581
TPTAV
586
ERDVH
591
RQVVV
596
VKEES
601
LHSIL
606
AGSDM
611
TVSQI
616
LLTQH
621
GIPVM
626
NLSDG
631
KAYCF
636
NPSLS
641
TWNLV
646
SDKQD
651
SLAQC
656
ADFRS
661
SLPSQ
666
DAMLC
671
SGPLA
676
IIQGR
681
TSNSG
686
RQAAR
691
LFSVP
696
HVVQQ
701
ETTLA
706
YLENQ
711
VAAAL
716
TLQSS
721
HEYRH
726
WLLVY
731
ARYLV
736
NEGFE
741
YRLRE
746
ICKDL
751
LGPVH
756
YSTGS
761
QWEST
766
VVGLR
771
KRELL
776
KELLP
781
VIGQN
786
LRFQR
791
LFTEC
796
QEQLD
801
ILRDK
806
Mutation Information
DNA mutation:
None
Peptide Range:
604 ~ 628
Mut AA position:
616 (13 in Wild Type peptide)
Alignment
Wild Type:
"ESLHSILAGSDMTVSQILLTQHGIP
||||||||||||.||||||||||||
Mutant:
ESLHSILAGSDMMVSQILLTQHGIP"
reference

Science, 2015

Immunogenicity of somatic mutations in human gastrointestinal cancers

Gene Name (from Reference) HIRA

clinic trial
Checkpoint Blockade

None

ACT

None

Vaccination

None

Curative Effect

None

experiment
minimal_peptide

None

Antigen Type

TMG RNA

T-cell Source

TILs

APC Type

autologous DCs

Assay

IFNg ELISPOT assay