Immunogenicity 3621

summary
Sample ID
4069
Response
Negative
Tumor Type
Pancreatic cancer
Gene Symbol
SMC4
Transcript ID
uc010hwd.3
HLA INFO
DQA*03:01 / DQB*06:01
TCR INFO

No TCR info found!

T cell Tumor cell { DQA*03:01 DQB*06:01
sequence
Full length protein sequence (1230 aa)
MPRKG
1
TQPST
6
ARRRE
11
EGPPP
16
PSPDG
21
ASSDA
26
EPEPP
31
SGRTE
36
SPATA
41
AETAS
46
EELDN
51
RSLEE
56
ILNSI
61
PPPPP
66
PAMTN
71
EAGAP
76
RLMIT
81
HIVNQ
86
NFKSY
91
AGEKI
96
LGPFH
101
KRFSC
106
IIGPN
111
GSGKS
116
NVIDS
121
MLFVF
126
GYRAQ
131
KIRSK
136
KLSVL
141
IHNSD
146
EHKDI
151
QSCTV
156
EVHFQ
161
KIIDK
166
EGDDY
171
EVIPN
176
SNFYV
181
SRTAC
186
RDNTS
191
VYHIS
196
GKKKT
201
FKDVG
206
NLLRS
211
HGIDL
216
DHNRF
221
LILQG
226
EVEQI
231
AMMKP
236
KGQTE
241
HDEGM
246
LEYLE
251
DIIGC
256
GRLNE
261
PIKVL
266
CRRVE
271
ILNEH
276
RGEKL
281
NRVKM
286
VEKEK
291
DALEG
296
EKNIA
301
IEFLT
306
LENEI
311
FRKKN
316
HVCQY
321
YIYEL
326
QKRIA
331
EMETQ
336
KEKIH
341
EDTKE
346
INEKS
351
NILSN
356
EMKAK
361
NKDVK
366
DTEKK
371
LNKIT
376
KFIEE
381
NKEKF
386
TQLDL
391
EDVQV
396
REKLK
401
HATSK
406
AKKLE
411
KQLQK
416
DKEKV
421
EEFKS
426
IPAKS
431
NNIIN
436
ETTTR
441
NNALE
446
KEKEK
451
EEKKL
456
KEVMD
461
SLKQE
466
TQGLQ
471
KEKES
476
REKEL
481
MGFSK
486
SVNEA
491
RSKMD
496
VAQSE
501
LDIYL
506
SRHNT
511
AVSQL
516
TKAKE
521
ALIAA
526
SETLK
531
ERKAA
536
IRDIE
541
GKLPQ
546
TEQEL
551
KEKEK
556
ELQKL
561
TQEET
566
NFKSL
571
VHDLF
576
QKVEE
581
AKSSL
586
AMNRS
591
RGKVL
596
DAIIQ
601
EKKSG
606
RIPGI
611
YGRLG
616
DLGAI
621
DEKYD
626
VAISS
631
CCHAL
636
DYIVV
641
DSIDI
646
AQECV
651
NFLKR
656
QNIGV
661
ATFIG
666
LDKMA
671
VWAKK
676
MTEIQ
681
TPENT
686
PRLFD
691
LVKVK
696
DEKIR
701
QAFYF
706
ALRDT
711
LVADN
716
LDQAT
721
RVAYQ
726
KDRRW
731
RVVTL
736
QGQII
741
EQSGT
746
MTGGG
751
SKVMK
756
GRMGS
761
SLVIE
766
ISEEE
771
VNKME
776
SQLQN
781
DSKKA
786
MQIQE
791
QKVQL
796
EERVV
801
KLRHS
806
EREMR
811
NTLEK
816
FTASI
821
QRLIE
826
QEEYL
831
NVQVK
836
ELEAN
841
VLATA
846
PDKKK
851
QKLLE
856
ENVSA
861
FKTEY
866
DAVAE
871
KAGKV
876
EAEVK
881
RLHNT
886
IVEIN
891
NHKLK
896
AQQDK
901
LDKIN
906
KQLDE
911
CASAI
916
TKAQV
921
AIKTA
926
DRNLQ
931
KAQDS
936
VLRTE
941
KEIKD
946
TEKEV
951
DDLTA
956
ELKSL
961
EDKAA
966
EVVKN
971
TNAAE
976
ISKIS
981
LHPIE
986
DNPIE
991
EISVL
996
SPEDL
1001
EAIKN
1006
PDSIT
1011
NQIAL
1016
LEARC
1021
HEMKP
1026
NLGAI
1031
AEYKK
1036
KEELY
1041
LQRVA
1046
ELDKI
1051
TYERD
1056
SFRQA
1061
YEDLR
1066
KQRLN
1071
EFMAG
1076
FYIIT
1081
NKLKE
1086
NYQML
1091
TLGGD
1096
AELEL
1101
VDSLD
1106
PFSEG
1111
IMFSV
1116
RPPKK
1121
SWKKI
1126
FNLSG
1131
GEKTL
1136
SSLAL
1141
VFALH
1146
HYKPT
1151
PLYFM
1156
DEIDA
1161
ALDFK
1166
NVSIV
1171
AFYIY
1176
EQTKN
1181
AQFII
1186
ISLRN
1191
NMFEI
1196
SDRLI
1201
GIYKT
1206
YNITK
1211
SVAVN
1216
PKEIA
1221
SKGLC
1226
Mutation Information
DNA mutation:
None
Peptide Range:
467 ~ 491
Mut AA position:
479 (13 in Wild Type peptide)
Alignment
Wild Type:
"LKQETQGLQKEKESREKELMGFSKS
||||||||||||.||||||||||||
Mutant:
LKQETQGLQKEKKSREKELMGFSKS"
reference

Science, 2015

Immunogenicity of somatic mutations in human gastrointestinal cancers

Gene Name (from Reference) SMC4

clinic trial
Checkpoint Blockade

None

ACT

None

Vaccination

None

Curative Effect

None

experiment
minimal_peptide

None

Antigen Type

TMG RNA

T-cell Source

TILs

APC Type

autologous DCs

Assay

IFNg ELISPOT assay