Immunogenicity 4037

summary
Sample ID
3942
Response
Negative
Tumor Type
Rectal cancer
Gene Symbol
ADAM17
Transcript ID
uc003xni.3
HLA INFO
DQA*02:01 / DQB*02:02
TCR INFO

No TCR info found!

T cell Tumor cell { DQA*02:01 DQB*02:02
sequence
Full length protein sequence (739 aa)
MFLLL
1
ALLTE
6
LGRLQ
11
AHEGS
16
EGIFL
21
HVTVP
26
RKIKS
31
NDSEV
36
SERKM
41
IYIIT
46
IDGQP
51
YTLHL
56
GKQSF
61
LPQNF
66
LVYTY
71
NETGS
76
LHSVS
81
PYFMM
86
HCHYQ
91
GYAAE
96
FPNSF
101
VTLSI
106
CSGLR
111
GFLQF
116
ENISY
121
GIEPV
126
ESSAR
131
FEHII
136
YQMKN
141
NDPNV
146
SILAV
151
NYSHI
156
WQKDQ
161
PYKVP
166
LNSQI
171
KNLSK
176
LLPQY
181
LEIYI
186
IVEKA
191
LYDYM
196
GSEMM
201
AVTQK
206
IVQVI
211
GLVNT
216
MFTQF
221
KLTVI
226
LSSLE
231
LWSNE
236
NQIST
241
SGDAD
246
DILQR
251
FLAWK
256
RDYLI
261
LRPHD
266
IAYLL
271
VYRKH
276
PKYVG
281
ATFPG
286
TVCNK
291
SYDAG
296
IAMYP
301
DAIGL
306
EGFSV
311
IIAQL
316
LGLNV
321
GLTYD
326
DITQC
331
FCLRA
336
TCIMN
341
HEAVS
346
ASGRK
351
IFSNC
356
SMHDY
361
RYFVS
366
KFETK
371
CLQKL
376
SNLQP
381
LHQNQ
386
PVCGN
391
GILES
396
NEECD
401
CGNKN
406
ECQFK
411
KCCDY
416
NTCKL
421
KGSVK
426
CGSGP
431
CCTSK
436
CELSI
441
AGTPC
446
RKSID
451
PECDF
456
TEYCN
461
GTSSN
466
CVPDT
471
YALNG
476
RLCKL
481
GTAYC
486
YNGQC
491
QTTDN
496
QCAKI
501
FGKGA
506
QGAPF
511
ACFKE
516
VNSLH
521
ERSEN
526
CGFKN
531
SQPLP
536
CERKD
541
VLCGK
546
LACVQ
551
PHKNA
556
NKSDA
561
QSTVY
566
SYIQD
571
HVCVS
576
IATGS
581
SMRSD
586
GTDNA
591
YVADG
596
TMCGP
601
EMYCV
606
NKTCR
611
KVHLM
616
GYNCN
621
ATTKC
626
KGKGI
631
CNNFG
636
NCQCF
641
PGHRP
646
PDCKF
651
QFGSP
656
GGSID
661
DGNFQ
666
KSGDF
671
YTEKG
676
YNTHW
681
NNWFI
686
LSFCI
691
FLPFF
696
IVFTT
701
VIFKR
706
NEISK
711
SCNRE
716
NAEYN
721
RNSSV
726
VSESD
731
DVGH
736
Mutation Information
DNA mutation:
None
Peptide Range:
169 ~ 193
Mut AA position:
181 (13 in Wild Type peptide)
Alignment
Wild Type:
"VPLNSQIKNLSKLLPQYLEIYIIVE
||||||||||||.||||||||||||
Mutant:
VPLNSQIKNLSKVLPQYLEIYIIVE"
reference

Science, 2015

Immunogenicity of somatic mutations in human gastrointestinal cancers

Gene Name (from Reference) ADAM18

clinic trial
Checkpoint Blockade

None

ACT

None

Vaccination

None

Curative Effect

None

experiment
minimal_peptide

None

Antigen Type

TMG RNA

T-cell Source

TILs

APC Type

autologous DCs

Assay

IFNg ELISPOT assay