Immunogenicity 4122

summary
Sample ID
3948
Response
Negative
Tumor Type
Esophageal cancer
Gene Symbol
ASTN2
Transcript ID
uc022bml.1
HLA INFO
B*18:01
TCR INFO

No TCR info found!

T cell Tumor cell B*18:01
sequence
Full length protein sequence (984 aa)
MQKFK
1
ESFRA
6
NTPIE
11
IGQLQ
16
PPLRS
21
TSAGK
26
RKRRS
31
KSRGG
36
ISFGR
41
AKGTS
46
GSEAD
51
DETQL
56
TFYTE
61
QYRSR
66
RRSKG
71
LLKSP
76
VNKTA
81
LTLIA
86
VSSCI
91
LAMVC
96
GSQMS
101
CPLTV
106
KVTLH
111
VPEHF
116
IADGS
121
SFVVS
126
EGSYL
131
DISDW
136
LNPAK
141
LSLYY
146
QINAT
151
SPWVR
156
DLCGQ
161
RTTDA
166
CEQLC
171
DPETG
176
ECSCH
181
EGYAP
186
DPVHR
191
HLCVR
196
SDWGQ
201
SEGPW
206
PYTTL
211
ERGYD
216
LVTGE
221
QAPEK
226
ILSLG
231
QGLWL
236
PVSKS
241
FVVPP
246
VELSI
251
NPLAS
256
CKTDV
261
LVTED
266
PADVR
271
EEAML
276
STYFE
281
TINDL
286
LSSFG
291
PVRDC
296
SRNNG
301
GCTRN
306
FKCVS
311
DRQVD
316
SSGCV
321
CPEEL
326
KPMKD
331
GSGCY
336
DHSKG
341
IDCSD
346
GFNGG
351
CEQLC
356
LQQTL
361
PLPYD
366
ATSST
371
IFMFC
376
GCVEE
381
YKLAP
386
DGKSC
391
LMLSD
396
VCEGP
401
KCLKP
406
DSKFN
411
DTLFG
416
EMLHG
421
YNNRT
426
QHVNQ
431
GQVFQ
436
MTFRE
441
NNFIK
446
DFPQL
451
ADGLL
456
VIPLP
461
VEEQC
466
RGVLS
471
EPLPD
476
LQLLT
481
GDIRY
486
DEAMG
491
YPMVQ
496
QWRVR
501
SNLYR
506
VKLST
511
ITLAA
516
GFTNV
521
LKILT
526
KESSR
531
EELLS
536
FIQHY
541
GSHYI
546
AEALY
551
GSELT
556
CIIHF
561
PSKKV
566
QQQLW
571
LQYQK
576
ETTEL
581
GSKKE
586
LKSMP
591
FITYL
596
SGLLT
601
AQMLS
606
DDQLI
611
SGVEI
616
RCEEK
621
GRCPS
626
TCHLC
631
RRPGK
636
EQLSP
641
TPVLL
646
EINRV
651
VPLYT
656
LIQDN
661
GTKEA
666
FKSAL
671
MSSYW
676
CSGKG
681
DVIDD
686
WCRCD
691
LSAFD
696
ANGLP
701
NCSPL
706
LQPVL
711
RLSPT
716
VEPSS
721
TVVSL
726
EWVDV
731
QPAIG
736
TKVSD
741
YILQH
746
KKVDE
751
YTDTD
756
LYTGE
761
FLSFA
766
DDLLS
771
GLGTS
776
CVAAG
781
RSHGE
786
VPEVS
791
IYSVI
796
FKCLE
801
PDGLY
806
KFTLY
811
AVDTR
816
GRHSE
821
LSTVT
826
LRTAC
831
PLVDD
836
NKAEE
841
IADKI
846
YNLYN
851
GYTSG
856
KEQQM
861
AYNTL
866
MEVSA
871
SMLFR
876
VQHHY
881
NSHYE
886
KFGDF
891
VWRSE
896
DELGP
901
RKAHL
906
ILRRL
911
ERVSS
916
HCSSL
921
LRSAY
926
IQSRV
931
ETVPY
936
LFCRS
941
EEVRP
946
AGMVW
951
YSILK
956
DTKIT
961
CEEKM
966
VSMAR
971
NTYGE
976
SKGR
981
Mutation Information
DNA mutation:
None
Peptide Range:
16 ~ 40
Mut AA position:
28 (13 in Wild Type peptide)
Alignment
Wild Type:
"IGQLQPPLRSTSAGKRKRRSKSRGG
||||||||||||.||||||||||||
Mutant:
IGQLQPPLRSTSVGKRKRRSKSRGG"
reference

Science, 2015

Immunogenicity of somatic mutations in human gastrointestinal cancers

Gene Name (from Reference) ASTN2

clinic trial
Checkpoint Blockade

None

ACT

None

Vaccination

None

Curative Effect

None

experiment
minimal_peptide

None

Antigen Type

TMG RNA

T-cell Source

TILs

APC Type

autologous DCs

Assay

IFNg ELISPOT assay