Immunogenicity 432
Sample ID
None
Response
Negative
Tumor Type
Melanoma
Gene Symbol
SMC4
Transcript ID
None
HLA INFO
A*01:03
TCR INFO
No TCR info found!
Full length protein sequence (1288 aa)
MPRKG
1
TQPST
6
ARRRE
11
EGPPP
16
PSPDG
21
ASSDA
26
EPEPP
31
SGRTE
36
SPATA
41
AETAS
46
EELDN
51
RSLEE
56
ILNSI
61
PPPPP
66
PAMTN
71
EAGAP
76
RLMIT
81
HIVNQ
86
NFKSY
91
AGEKI
96
LGPFH
101
KRFSC
106
IIGPN
111
GSGKS
116
NVIDS
121
MLFVF
126
GYRAQ
131
KIRSK
136
KLSVL
141
IHNSD
146
EHKDI
151
QSCTV
156
EVHFQ
161
KIIDK
166
EGDDY
171
EVIPN
176
SNFYV
181
SRTAC
186
RDNTS
191
VYHIS
196
GKKKT
201
FKDVG
206
NLLRS
211
HGIDL
216
DHNRF
221
LILQG
226
EVEQI
231
AMMKP
236
KGQTE
241
HDEGM
246
LEYLE
251
DIIGC
256
GRLNE
261
PIKVL
266
CRRVE
271
ILNEH
276
RGEKL
281
NRVKM
286
VEKEK
291
DALEG
296
EKNIA
301
IEFLT
306
LENEI
311
FRKKN
316
HVCQY
321
YIYEL
326
QKRIA
331
EMETQ
336
KEKIH
341
EDTKE
346
INEKS
351
NILSN
356
EMKAK
361
NKDVK
366
DTEKK
371
LNKIT
376
KFIEE
381
NKEKF
386
TQLDL
391
EDVQV
396
REKLK
401
HATSK
406
AKKLE
411
KQLQK
416
DKEKV
421
EEFKS
426
IPAKS
431
NNIIN
436
ETTTR
441
NNALE
446
KEKEK
451
EEKKL
456
KEVMD
461
SLKQE
466
TQGLQ
471
KEKES
476
REKEL
481
MGFSK
486
SVNEA
491
RSKMD
496
VAQSE
501
LDIYL
506
SRHNT
511
AVSQL
516
TKAKE
521
ALIAA
526
SETLK
531
ERKAA
536
IRDIE
541
GKLPQ
546
TEQEL
551
KEKEK
556
ELQKL
561
TQEET
566
NFKSL
571
VHDLF
576
QKVEE
581
AKSSL
586
AMNRS
591
RGKVL
596
DAIIQ
601
EKKSG
606
RIPGI
611
YGRLG
616
DLGAI
621
DEKYD
626
VAISS
631
CCHAL
636
DYIVV
641
DSIDI
646
AQECV
651
NFLKR
656
QNIGV
661
ATFIG
666
LDKMA
671
VWAKK
676
MTEIQ
681
TPENT
686
PRLFD
691
LVKVK
696
DEKIR
701
QAFYF
706
ALRDT
711
LVADN
716
LDQAT
721
RVAYQ
726
KDRRW
731
RVVTL
736
QGQII
741
EQSGT
746
MTGGG
751
SKVMK
756
GRMGS
761
SLVIE
766
ISEEE
771
VNKME
776
SQLQN
781
DSKKA
786
MQIQE
791
QKVQL
796
EERVV
801
KLRHS
806
EREMR
811
NTLEK
816
FTASI
821
QRLIE
826
QEEYL
831
NVQVK
836
ELEAN
841
VLATA
846
PDKKK
851
QKLLE
856
ENVSA
861
FKTEY
866
DAVAE
871
KAGKV
876
EAEVK
881
RLHNT
886
IVEIN
891
NHKLK
896
AQQDK
901
LDKIN
906
KQLDE
911
CASAI
916
TKAQV
921
AIKTA
926
DRNLQ
931
KAQDS
936
VLRTE
941
KEIKD
946
TEKEV
951
DDLTA
956
ELKSL
961
EDKAA
966
EVVKN
971
TNAAE
976
ESLPE
981
IQKEH
986
RNLLQ
991
ELKVI
996
QENEH
1001
ALQKD
1006
ALSIK
1011
LKLEQ
1016
IDGHI
1021
AEHNS
1026
KIKYW
1031
HKEIS
1036
KISLH
1041
PIEDN
1046
PIEEI
1051
SVLSP
1056
EDLEA
1061
IKNPD
1066
SITNQ
1071
IALLE
1076
ARCHE
1081
MKPNL
1086
GAIAE
1091
YKKKE
1096
ELYLQ
1101
RVAEL
1106
DKITY
1111
ERDSF
1116
RQAYE
1121
DLRKQ
1126
RLNEF
1131
MAGFY
1136
IITNK
1141
LKENY
1146
QMLTL
1151
GGDAE
1156
LELVD
1161
SLDPF
1166
SEGIM
1171
FSVRP
1176
PKKSW
1181
KKIFN
1186
LSGGE
1191
KTLSS
1196
LALVF
1201
ALHHY
1206
KPTPL
1211
YFMDE
1216
IDAAL
1221
DFKNV
1226
SIVAF
1231
YIYEQ
1236
TKNAQ
1241
FIIIS
1246
LRNNM
1251
FEISD
1256
RLIGI
1261
YKTYN
1266
ITKSV
1271
AVNPK
1276
EIASK
1281
GLC
1286
Mutation Information
DNA mutation:
None
Peptide Range:
1258 ~ 1281
Mut AA position:
1262 (5 in Wild Type peptide)
Alignment
Wild Type:
"--------ISDRLIGIY-------
||||.||||
Mutant:
SLRNNMFEISDRFIGIYKTYNITK"
Nature, 2017
An immunogenic personal neoantigen vaccine for patients with melanomaGene Name (from Reference) SMC4
Checkpoint
Blockade
None
ACT
None
Vaccination
None
Curative
Effect
None
minimal_peptide
None
Antigen
Type
peptide
T-cell
Source
PBMCs
APC
Type
autologous APCs
Assay
IFNg ELISPOT assay