Immunogenicity 434
Sample ID
None
Response
Negative
Tumor Type
Melanoma
Gene Symbol
POLQ
Transcript ID
None
HLA INFO
B*38:01
TCR INFO
No TCR info found!
Full length protein sequence (2591 aa)
MNLLR
1
RSGKR
6
RRSES
11
GSDSF
16
SGSGG
21
DSSAS
26
PQFLS
31
GSVLS
36
PPPGL
41
GRCLK
46
AAAAG
51
ECKPT
56
VPDYE
61
RDKLL
66
LANWG
71
LPKAV
76
LEKYH
81
SFGVK
86
KMFEW
91
QAECL
96
LLGQV
101
LEGKN
106
LVYSA
111
PTSAG
116
KTLVA
121
ELLIL
126
KRVLE
131
MRKKA
136
LFILP
141
FVSVA
146
KEKKY
151
YLQSL
156
FQEVG
161
IKVDG
166
YMGST
171
SPSRH
176
FSSLD
181
IAVCT
186
IERAN
191
GLINR
196
LIEEN
201
KMDLL
206
GMVVV
211
DELHM
216
LGDSH
221
RGYLL
226
ELLLT
231
KICYI
236
TRKSA
241
SCQAD
246
LASSL
251
SNAVQ
256
IVGMS
261
ATLPN
266
LELVA
271
SWLNA
276
ELYHT
281
DFRPV
286
PLLES
291
VKVGN
296
SIYDS
301
SMKLV
306
REFEP
311
MLQVK
316
GDEDH
321
VVSLC
326
YETIC
331
DNHSV
336
LLFCP
341
SKKWC
346
EKLAD
351
IIARE
356
FYNLH
361
HQAEG
366
LVKPS
371
ECPPV
376
ILEQK
381
ELLEV
386
MDQLR
391
RLPSG
396
LDSVL
401
QKTVP
406
WGVAF
411
HHAGL
416
TFEER
421
DIIEG
426
AFRQG
431
LIRVL
436
AATST
441
LSSGV
446
NLPAR
451
RVIIR
456
TPIFG
461
GRPLD
466
ILTYK
471
QMVGR
476
AGRKG
481
VDTVG
486
ESILI
491
CKNSE
496
KSKGI
501
ALLQG
506
SLKPV
511
RSCLQ
516
RREGE
521
EVTGS
526
MIRAI
531
LEIIV
536
GGVAS
541
TSQDM
546
HTYAA
551
CTFLA
556
ASMKE
561
GKQGI
566
QRNQE
571
SVQLG
576
AIEAC
581
VMWLL
586
ENEFI
591
QSTEA
596
SDGTE
601
GKVYH
606
PTHLG
611
SATLS
616
SSLSP
621
ADTLD
626
IFADL
631
QRAMK
636
GFVLE
641
NDLHI
646
LYLVT
651
PMFED
656
WTTID
661
WYRFF
666
CLWEK
671
LPTSM
676
KRVAE
681
LVGVE
686
EGFLA
691
RCVKG
696
KVVAR
701
TERQH
706
RQMAI
711
HKRFF
716
TSLVL
721
LDLIS
726
EVPLR
731
EINQK
736
YGCNR
741
GQIQS
746
LQQSA
751
AVYAG
756
MITVF
761
SNRLG
766
WHNME
771
LLLSQ
776
FQKRL
781
TFGIQ
786
RELCD
791
LVRVS
796
LLNAQ
801
RARVL
806
YASGF
811
HTVAD
816
LARAN
821
IVEVE
826
VILKN
831
AVPFK
836
SARKA
841
VDEEE
846
EAVEE
851
RRNMR
856
TIWVT
861
GRKGL
866
TEREA
871
AALIV
876
EEARM
881
ILQQD
886
LVEMG
891
VQWNP
896
CALLH
901
SSTCS
906
LTHSE
911
SEVKE
916
HTFIS
921
QTKSS
926
YKKLT
931
SKNKS
936
NTIFS
941
DSYIK
946
HSPNI
951
VQDLN
956
KSREH
961
TSSFN
966
CNFQN
971
GNQEH
976
QTCSI
981
FRARK
986
RASLD
991
INKEK
996
PGASQ
1001
NEGKT
1006
SDKKV
1011
VQTFS
1016
QKTKK
1021
APLNF
1026
NSEKM
1031
SRSFR
1036
SWKRR
1041
KHLKR
1046
SRDSS
1051
PLKDS
1056
GACRI
1061
HLQGQ
1066
TLSNP
1071
SLCED
1076
PFTLD
1081
EKKTE
1086
FRNSG
1091
PFAKN
1096
VSLSG
1101
KEKDN
1106
KTSFP
1111
LQIKQ
1116
NCSWN
1121
ITLTN
1126
DNFVE
1131
HIVTG
1136
SQSKN
1141
VTCQA
1146
TSVVS
1151
EKGRG
1156
VAVEA
1161
EKINE
1166
VLIQN
1171
GSKNQ
1176
NVYMK
1181
HHDIH
1186
PINQY
1191
LRKQS
1196
HEQTS
1201
TITKQ
1206
KNIIE
1211
RQMPC
1216
EAVSS
1221
YINRD
1226
SNVTI
1231
NCERI
1236
KLNTE
1241
ENKPS
1246
HFQAL
1251
GDDIS
1256
RTVIP
1261
SEVLP
1266
SAGAF
1271
SKSEG
1276
QHENF
1281
LNISR
1286
LQEKT
1291
GTYTT
1296
NKTKN
1301
NHVSD
1306
LGLVL
1311
CDFED
1316
SFYLD
1321
TQSEK
1326
IIQQM
1331
ATENA
1336
KLGAK
1341
DTNLA
1346
AGIMQ
1351
KSLVQ
1356
QNSMN
1361
SFQKE
1366
CHIPF
1371
PAEQH
1376
PLGAT
1381
KIDHL
1386
DLKTV
1391
GTMKQ
1396
SSDSH
1401
GVDIL
1406
TPESP
1411
IFHSP
1416
ILLEE
1421
NGLFL
1426
KKNEV
1431
SVTDS
1436
QLNSF
1441
LQGYQ
1446
TQETV
1451
KPVIL
1456
LIPQK
1461
RTPTG
1466
VEGEC
1471
LPVPE
1476
TSLNM
1481
SDSLL
1486
FDSFS
1491
DDYLV
1496
KEQLP
1501
DMQMK
1506
EPLPS
1511
EVTSN
1516
HFSDS
1521
LCLQE
1526
DLIKK
1531
SNVNE
1536
NQDTH
1541
QQLTC
1546
SNDES
1551
IIFSE
1556
MDSVQ
1561
MVEAL
1566
DNVDI
1571
FPVQE
1576
KNHTV
1581
VSPRA
1586
LELSD
1591
PVLDE
1596
HHQGD
1601
QDGGD
1606
QDERA
1611
EKSKL
1616
TGTRQ
1621
NHSFI
1626
WSGAS
1631
FDLSP
1636
GLQRI
1641
LDKVS
1646
SPLEN
1651
EKLKS
1656
MTINF
1661
SSLNR
1666
KNTEL
1671
NEEQE
1676
VISNL
1681
ETKQV
1686
QGISF
1691
SSNNE
1696
VKSKI
1701
EMLEN
1706
NANHD
1711
ETSSL
1716
LPRKE
1721
SNIVD
1726
DNGLI
1731
PPTPI
1736
PTSAS
1741
KLTFP
1746
GILET
1751
PVNPW
1756
KTNNV
1761
LQPGE
1766
SYLFG
1771
SPSDI
1776
KNHDL
1781
SPGSR
1786
NGFKD
1791
NSPIS
1796
DTSFS
1801
LQLSQ
1806
DGLQL
1811
TPASS
1816
SSESL
1821
SIIDV
1826
ASDQN
1831
LFQTF
1836
IKEWR
1841
CKKRF
1846
SISLA
1851
CEKIR
1856
SLTSS
1861
KTATI
1866
GSRFK
1871
QASSP
1876
QEIPI
1881
RDDGF
1886
PIKGC
1891
DDTLV
1896
VGLAV
1901
CWGGR
1906
DAYYF
1911
SLQKE
1916
QKHSE
1921
ISASL
1926
VPPSL
1931
DPSLT
1936
LKDRM
1941
WYLQS
1946
CLRKE
1951
SDKEC
1956
SVVIY
1961
DFIQS
1966
YKILL
1971
LSCGI
1976
SLEQS
1981
YEDPK
1986
VACWL
1991
LDPDS
1996
QEPTL
2001
HSIVT
2006
SFLPH
2011
ELPLL
2016
EGMET
2021
SQGIQ
2026
SLGLN
2031
AGSEH
2036
SGRYR
2041
ASVES
2046
ILIFN
2051
SMNQL
2056
NSLLQ
2061
KENLQ
2066
DVFRK
2071
VEMPS
2076
QYCLA
2081
LLELN
2086
GIGFS
2091
TAECE
2096
SQKHI
2101
MQAKL
2106
DAIET
2111
QAYQL
2116
AGHSF
2121
SFTSS
2126
DDIAE
2131
VLFLE
2136
LKLPP
2141
NREMK
2146
NQGSK
2151
KTLGS
2156
TRRGI
2161
DNGRK
2166
LRLGR
2171
QFSTS
2176
KDVLN
2181
KLKAL
2186
HPLPG
2191
LILEW
2196
RRITN
2201
AITKV
2206
VFPLQ
2211
REKCL
2216
NPFLG
2221
MERIY
2226
PVSQS
2231
HTATG
2236
RITFT
2241
EPNIQ
2246
NVPRD
2251
FEIKM
2256
PTLVG
2261
ESPPS
2266
QAVGK
2271
GLLPM
2276
GRGKY
2281
KKGFS
2286
VNPRC
2291
QAQME
2296
ERAAD
2301
RGMPF
2306
SISMR
2311
HAFVP
2316
FPGGS
2321
ILAAD
2326
YSQLE
2331
LRILA
2336
HLSHD
2341
RRLIQ
2346
VLNTG
2351
ADVFR
2356
SIAAE
2361
WKMIE
2366
PESVG
2371
DDLRQ
2376
QAKQI
2381
CYGII
2386
YGMGA
2391
KSLGE
2396
QMGIK
2401
ENDAA
2406
CYIDS
2411
FKSRY
2416
TGINQ
2421
FMTET
2426
VKNCK
2431
RDGFV
2436
QTILG
2441
RRRYL
2446
PGIKD
2451
NNPYR
2456
KAHAE
2461
RQAIN
2466
TIVQG
2471
SAADI
2476
VKIAT
2481
VNIQK
2486
QLETF
2491
HSTFK
2496
SHGHR
2501
EGMLQ
2506
SDQTV
2511
GLSRK
2516
RKLQG
2521
MFCPI
2526
RGGFF
2531
ILQLH
2536
DELLY
2541
EVAEE
2546
DVVQV
2551
AQIVK
2556
NEMES
2561
AVKLS
2566
VKLKV
2571
KVKIG
2576
ASWGE
2581
LKDFD
2586
V
2591
Mutation Information
DNA mutation:
None
Peptide Range:
1713 ~ 1735
Mut AA position:
1719 (7 in Wild Type peptide)
Alignment
Wild Type:
"-----NHDETSSLL---------
||||||.||
Mutant:
LENNANHDETSFLLPRKESNIVD"
Nature, 2017
An immunogenic personal neoantigen vaccine for patients with melanomaGene Name (from Reference) POLQ
Checkpoint
Blockade
None
ACT
None
Vaccination
None
Curative
Effect
None
minimal_peptide
None
Antigen
Type
None
T-cell
Source
PBMCs
APC
Type
autologous APCs
Assay
IFNg ELISPOT assay