Immunogenicity 4647

summary
Sample ID
3948
Response
Negative
Tumor Type
Esophageal cancer
Gene Symbol
ZNF493
Transcript ID
NM_001076678
HLA INFO
C*12:03
TCR INFO

No TCR info found!

T cell Tumor cell C*12:03
sequence
Full length protein sequence (774 aa)
MPGPP
1
ESLDM
6
GPLTF
11
RDVAI
16
EFSLE
21
EWQCL
26
DTAQQ
31
DLYRK
36
VMLEN
41
YRNLV
46
FLGIA
51
VSKPD
56
LVTCL
61
EQGKD
66
PWNMK
71
GHSTV
76
VKPPV
81
ICSHF
86
AEDFC
91
PGPGI
96
KDSFQ
101
KVILR
106
EYVKC
111
GHKDL
116
QLRKG
121
CKSMN
126
ECNVH
131
KEGYN
136
ELNQY
141
LTTTQ
146
SKIFQ
151
CDKYV
156
KVFHK
161
LLNSN
166
RHNTK
171
HTGKK
176
PFKCK
181
KCGKS
186
FCMLL
191
HLCQH
196
KRIHI
201
RENSY
206
RCEEC
211
GKAFI
216
WFSTL
221
TRHRR
226
VHTGE
231
KSYKY
236
ECGKS
241
FNQDS
246
NLTTH
251
KRIHT
256
GQKPY
261
KCEEC
266
GTSFY
271
QFSYL
276
TRHKL
281
IHTRE
286
KPYKC
291
EQYGK
296
TFNQS
301
STLTG
306
HKIIH
311
NGEKP
316
YKCEE
321
CGKAF
326
SIFST
331
PTKHK
336
IIHTE
341
EKSHR
346
CEEYC
351
KAYKE
356
SSHLT
361
THKRI
366
HTGEK
371
PYKCE
376
ECGKA
381
FSIFS
386
TLTKH
391
KIIHT
396
EEKSH
401
RCEEC
406
GKAYK
411
ESSHL
416
TTHKR
421
IHTGE
426
KPYKC
431
EECGK
436
TFSVF
441
SILTK
446
HKIIH
451
TEEKP
456
YKCEE
461
CGKAF
466
KRSST
471
LTKHR
476
IIHTE
481
EKPYK
486
CEECG
491
KAFNQ
496
SSTLS
501
IHKII
506
HTGEK
511
PYKCE
516
ECGKA
521
FKRSS
526
TLTIH
531
KMIHT
536
GEKPY
541
KCEEC
546
GKAFN
551
RSSHL
556
TTHKR
561
IHTGH
566
KPYKC
571
KECGK
576
SFSVF
581
STLTK
586
HKIIH
591
TDKKP
596
YKCEE
601
CGKAF
606
NRSSI
611
LSIHK
616
KIHTG
621
EKPYK
626
CEECG
631
KAFKR
636
SSHLA
641
GHKQI
646
HSVQK
651
PYKCE
656
ECGKA
661
FSIFS
666
TLTKH
671
KIIHT
676
EEKPY
681
KCEKC
686
GKTFY
691
RFSNL
696
NTHKI
701
IHTGE
706
KPCKC
711
EECGK
716
AFNHS
721
SNLIK
726
HKLIH
731
TGDKP
736
YKCEA
741
CGKAF
746
RRSSH
751
LSRHK
756
IIHIG
761
IHTEE
766
TVQK
771
Mutation Information
DNA mutation:
None
Peptide Range:
458 ~ 497
Mut AA position:
470 (13 in Wild Type peptide)
Alignment
Wild Type:
"EKPYKCEECGKAFKRSSTLTKHRII---------------
||||||||||||.|||||||||..|
Mutant:
EKPYKCEECGKAYKRSSTLTKHKRIHTGEKPYKCEECGKA"
reference

Science, 2015

Immunogenicity of somatic mutations in human gastrointestinal cancers

Gene Name (from Reference) ZNF493

clinic trial
Checkpoint Blockade

None

ACT

None

Vaccination

None

Curative Effect

None

experiment
minimal_peptide

None

Antigen Type

TMG RNA

T-cell Source

TILs

APC Type

autologous DCs

Assay

IFNg ELISPOT assay