Immunogenicity 479

summary
Sample ID
None
Response
Negative
Tumor Type
Melanoma
Gene Symbol
ZNF281
Transcript ID
None
HLA INFO
B*35:01
TCR INFO

No TCR info found!

T cell Tumor cell B*35:01
sequence
Full length protein sequence (895 aa)
MKIGS
1
GFLSG
6
GGGTG
11
SSGGS
16
GSGGG
21
GSGGG
26
GGGGS
31
SGRRA
36
EMEPT
41
FPQGM
46
VMFNH
51
RLPPV
56
TSFTR
61
PAGSA
66
APPPQ
71
CVLSS
76
STSAA
81
PAAEP
86
PPPPA
91
PDMTF
96
KKEPA
101
ASAAA
106
FPSQR
111
TSWGF
116
LQSLV
121
SIKQE
126
KPADP
131
EEQQS
136
HHHHH
141
HHHYG
146
GLFAG
151
AEERS
156
PGLGG
161
GEGGS
166
HGVIQ
171
DLSIL
176
HQHVQ
181
QQPAQ
186
HHRDV
191
LLSSS
196
SRTDD
201
HHGTE
206
EPKQD
211
TNVKK
216
AKRPK
221
PESQG
226
IKAKR
231
KPSAS
236
SKPSL
241
VGDGE
246
GAILS
251
PSQKP
256
HICDH
261
CSAAF
266
RSSYH
271
LRRHV
276
LIHTG
281
ERPFQ
286
CSQCS
291
MGFIQ
296
KYLLQ
301
RHEKI
306
HSREK
311
PFGCD
316
QCSMK
321
FIQKY
326
HMERH
331
KRTHS
336
GEKPY
341
KCDTC
346
QQYFS
351
RTDRL
356
LKHRR
361
TCGEV
366
IVKGA
371
TSAEP
376
GSSNH
381
TNMGN
386
LAVLS
391
QGNTS
396
SSRRK
401
TKSKS
406
IAIEN
411
KEQKT
416
GKTNE
421
SQISN
426
NINMQ
431
SYSVE
436
MPTVS
441
SSGGI
446
IGTGI
451
DELQK
456
RVPKL
461
IFKKG
466
SRKNT
471
DKNYL
476
NFVSP
481
LPDIV
486
GQKSL
491
SGKPS
496
GSLGI
501
VSNNS
506
VETIG
511
LLQST
516
SGKQG
521
QISSN
526
YDDAM
531
QFSKK
536
RRYLP
541
TASSN
546
SAFSI
551
NVGHM
556
VSQQS
561
VIQSA
566
GVSVL
571
DNEAP
576
LSLID
581
SSALN
586
AEIKS
591
CHDKS
596
GIPDE
601
VLQSI
606
LDQYS
611
NKSES
616
QKEDP
621
FNIAE
626
PRVDL
631
HTSGE
636
HSELV
641
QEENL
646
SPGTQ
651
TPSND
656
KASML
661
QEYSK
666
YLQQA
671
FEKST
676
NASFT
681
LGHGF
686
QFVSL
691
SSPLH
696
NHTLF
701
PEKQI
706
YTTSP
711
LECGF
716
GQSVT
721
SVLPS
726
SLPKP
731
PFGML
736
FGSQP
741
GLYLS
746
ALDAT
751
HQQLT
756
PSQEL
761
DDLID
766
SQKNL
771
ETSSA
776
FQSSS
781
QKLTS
786
QKEQK
791
NLESS
796
TGFQI
801
PSQEL
806
ASQID
811
PQKDI
816
EPRTT
821
YQIEN
826
FAQAF
831
GSQFK
836
SGSRV
841
PMTFI
846
TNSNG
851
EVDHR
856
VRTSV
861
SDFSG
866
YTNMM
871
SDVSE
876
PCSTR
881
VKTPT
886
SQSYR
891
Mutation Information
DNA mutation:
None
Peptide Range:
111 ~ 137
Mut AA position:
119 (9 in Wild Type peptide)
Alignment
Wild Type:
"------FPSQRTSWGF-----------
||||||||.|
Mutant:
AASAAAFPSQRTSWEFLQSLVSIKQEK"
reference

Nature, 2017

An immunogenic personal neoantigen vaccine for patients with melanoma

Gene Name (from Reference) ZNF281

clinic trial
Checkpoint Blockade

None

ACT

None

Vaccination

None

Curative Effect

None

experiment
minimal_peptide

None

Antigen Type

None

T-cell Source

PBMCs

APC Type

autologous APCs

Assay

IFNg ELISPOT assay