Immunogenicity 4883

summary
Sample ID
4007
Response
Negative
Tumor Type
Colon cancer
Gene Symbol
PIK3CA
Transcript ID
NM_006218
HLA INFO
A*03:01
TCR INFO

No TCR info found!

T cell Tumor cell A*03:01
sequence
Full length protein sequence (1068 aa)
MPPRP
1
SSGEL
6
WGIHL
11
MPPRI
16
LVECL
21
LPNGM
26
IVTLE
31
CLREA
36
TLITI
41
KHELF
46
KEARK
51
YPLHQ
56
LLQDE
61
SSYIF
66
VSVTQ
71
EAERE
76
EFFDE
81
TRRLC
86
DLRLF
91
QPFLK
96
VIEPV
101
GNREE
106
KILNR
111
EIGFA
116
IGMPV
121
CEFDM
126
VKDPE
131
VQDFR
136
RNILN
141
VCKEA
146
VDLRD
151
LNSPH
156
SRAMY
161
VYPPN
166
VESSP
171
ELPKH
176
IYNKL
181
DKGQI
186
IVVIW
191
VIVSP
196
NNDKQ
201
KYTLK
206
INHDC
211
VPEQV
216
IAEAI
221
RKKTR
226
SMLLS
231
SEQLK
236
LCVLE
241
YQGKY
246
ILKVC
251
GCDEY
256
FLEKY
261
PLSQY
266
KYIRS
271
CIMLG
276
RMPNL
281
MLMAK
286
ESLYS
291
QLPMD
296
CFTMP
301
SYSRR
306
ISTAT
311
PYMNG
316
ETSTK
321
SLWVI
326
NSALR
331
IKILC
336
ATYVN
341
VNIRD
346
IDKIY
351
VRTGI
356
YHGGE
361
PLCDN
366
VNTQR
371
VPCSN
376
PRWNE
381
WLNYD
386
IYIPD
391
LPRAA
396
RLCLS
401
ICSVK
406
GRKGA
411
KEEHC
416
PLAWG
421
NINLF
426
DYTDT
431
LVSGK
436
MALNL
441
WPVPH
446
GLEDL
451
LNPIG
456
VTGSN
461
PNKET
466
PCLEL
471
EFDWF
476
SSVVK
481
FPDMS
486
VIEEH
491
ANWSV
496
SREAG
501
FSYSH
506
AGLSN
511
RLARD
516
NELRE
521
NDKEQ
526
LKAIS
531
TRDPL
536
SEITE
541
QEKDF
546
LWSHR
551
HYCVT
556
IPEIL
561
PKLLL
566
SVKWN
571
SRDEV
576
AQMYC
581
LVKDW
586
PPIKP
591
EQAME
596
LLDCN
601
YPDPM
606
VRGFA
611
VRCLE
616
KYLTD
621
DKLSQ
626
YLIQL
631
VQVLK
636
YEQYL
641
DNLLV
646
RFLLK
651
KALTN
656
QRIGH
661
FFFWH
666
LKSEM
671
HNKTV
676
SQRFG
681
LLLES
686
YCRAC
691
GMYLK
696
HLNRQ
701
VEAME
706
KLINL
711
TDILK
716
QEKKD
721
ETQKV
726
QMKFL
731
VEQMR
736
RPDFM
741
DALQG
746
FLSPL
751
NPAHQ
756
LGNLR
761
LEECR
766
IMSSA
771
KRPLW
776
LNWEN
781
PDIMS
786
ELLFQ
791
NNEII
796
FKNGD
801
DLRQD
806
MLTLQ
811
IIRIM
816
ENIWQ
821
NQGLD
826
LRMLP
831
YGCLS
836
IGDCV
841
GLIEV
846
VRNSH
851
TIMQI
856
QCKGG
861
LKGAL
866
QFNSH
871
TLHQW
876
LKDKN
881
KGEIY
886
DAAID
891
LFTRS
896
CAGYC
901
VATFI
906
LGIGD
911
RHNSN
916
IMVKD
921
DGQLF
926
HIDFG
931
HFLDH
936
KKKKF
941
GYKRE
946
RVPFV
951
LTQDF
956
LIVIS
961
KGAQE
966
CTKTR
971
EFERF
976
QEMCY
981
KAYLA
986
IRQHA
991
NLFIN
996
LFSMM
1001
LGSGM
1006
PELQS
1011
FDDIA
1016
YIRKT
1021
LALDK
1026
TEQEA
1031
LEYFM
1036
KQMND
1041
AHHGG
1046
WTTKM
1051
DWIFH
1056
TIKQH
1061
ALN
1066
Mutation Information
DNA mutation:
None
Peptide Range:
353 ~ 377
Mut AA position:
365 (13 in Wild Type peptide)
Alignment
Wild Type:
"KIYVRTGIYHGGEPLCDNVNTQRVP
||||||||||||.||||||||||||
Mutant:
KIYVRTGIYHGGKPLCDNVNTQRVP"
reference

Science, 2015

Immunogenicity of somatic mutations in human gastrointestinal cancers

Gene Name (from Reference) PIK3CA

clinic trial
Checkpoint Blockade

None

ACT

None

Vaccination

None

Curative Effect

None

experiment
minimal_peptide

None

Antigen Type

TMG RNA

T-cell Source

TILs

APC Type

autologous DCs

Assay

IFNg ELISPOT assay