Immunogenicity 4908

summary
Sample ID
4007
Response
Negative
Tumor Type
Colon cancer
Gene Symbol
IGF1R
Transcript ID
NM_000875
HLA INFO
DQA*01:02 / DQB*06:02
TCR INFO

No TCR info found!

T cell Tumor cell { DQA*01:02 DQB*06:02
sequence
Full length protein sequence (1367 aa)
MKSGS
1
GGGSP
6
TSLWG
11
LLFLS
16
AALSL
21
WPTSG
26
EICGP
31
GIDIR
36
NDYQQ
41
LKRLE
46
NCTVI
51
EGYLH
56
ILLIS
61
KAEDY
66
RSYRF
71
PKLTV
76
ITEYL
81
LLFRV
86
AGLES
91
LGDLF
96
PNLTV
101
IRGWK
106
LFYNY
111
ALVIF
116
EMTNL
121
KDIGL
126
YNLRN
131
ITRGA
136
IRIEK
141
NADLC
146
YLSTV
151
DWSLI
156
LDAVS
161
NNYIV
166
GNKPP
171
KECGD
176
LCPGT
181
MEEKP
186
MCEKT
191
TINNE
196
YNYRC
201
WTTNR
206
CQKMC
211
PSTCG
216
KRACT
221
ENNEC
226
CHPEC
231
LGSCS
236
APDND
241
TACVA
246
CRHYY
251
YAGVC
256
VPACP
261
PNTYR
266
FEGWR
271
CVDRD
276
FCANI
281
LSAES
286
SDSEG
291
FVIHD
296
GECMQ
301
ECPSG
306
FIRNG
311
SQSMY
316
CIPCE
321
GPCPK
326
VCEEE
331
KKTKT
336
IDSVT
341
SAQML
346
QGCTI
351
FKGNL
356
LINIR
361
RGNNI
366
ASELE
371
NFMGL
376
IEVVT
381
GYVKI
386
RHSHA
391
LVSLS
396
FLKNL
401
RLILG
406
EEQLE
411
GNYSF
416
YVLDN
421
QNLQQ
426
LWDWD
431
HRNLT
436
IKAGK
441
MYFAF
446
NPKLC
451
VSEIY
456
RMEEV
461
TGTKG
466
RQSKG
471
DINTR
476
NNGER
481
ASCES
486
DVLHF
491
TSTTT
496
SKNRI
501
IITWH
506
RYRPP
511
DYRDL
516
ISFTV
521
YYKEA
526
PFKNV
531
TEYDG
536
QDACG
541
SNSWN
546
MVDVD
551
LPPNK
556
DVEPG
561
ILLHG
566
LKPWT
571
QYAVY
576
VKAVT
581
LTMVE
586
NDHIR
591
GAKSE
596
ILYIR
601
TNASV
606
PSIPL
611
DVLSA
616
SNSSS
621
QLIVK
626
WNPPS
631
LPNGN
636
LSYYI
641
VRWQR
646
QPQDG
651
YLYRH
656
NYCSK
661
DKIPI
666
RKYAD
671
GTIDI
676
EEVTE
681
NPKTE
686
VCGGE
691
KGPCC
696
ACPKT
701
EAEKQ
706
AEKEE
711
AEYRK
716
VFENF
721
LHNSI
726
FVPRP
731
ERKRR
736
DVMQV
741
ANTTM
746
SSRSR
751
NTTAA
756
DTYNI
761
TDPEE
766
LETEY
771
PFFES
776
RVDNK
781
ERTVI
786
SNLRP
791
FTLYR
796
IDIHS
801
CNHEA
806
EKLGC
811
SASNF
816
VFART
821
MPAEG
826
ADDIP
831
GPVTW
836
EPRPE
841
NSIFL
846
KWPEP
851
ENPNG
856
LILMY
861
EIKYG
866
SQVED
871
QRECV
876
SRQEY
881
RKYGG
886
AKLNR
891
LNPGN
896
YTARI
901
QATSL
906
SGNGS
911
WTDPV
916
FFYVQ
921
AKTGY
926
ENFIH
931
LIIAL
936
PVAVL
941
LIVGG
946
LVIML
951
YVFHR
956
KRNNS
961
RLGNG
966
VLYAS
971
VNPEY
976
FSAAD
981
VYVPD
986
EWEVA
991
REKIT
996
MSREL
1001
GQGSF
1006
GMVYE
1011
GVAKG
1016
VVKDE
1021
PETRV
1026
AIKTV
1031
NEAAS
1036
MRERI
1041
EFLNE
1046
ASVMK
1051
EFNCH
1056
HVVRL
1061
LGVVS
1066
QGQPT
1071
LVIME
1076
LMTRG
1081
DLKSY
1086
LRSLR
1091
PEMEN
1096
NPVLA
1101
PPSLS
1106
KMIQM
1111
AGEIA
1116
DGMAY
1121
LNANK
1126
FVHRD
1131
LAARN
1136
CMVAE
1141
DFTVK
1146
IGDFG
1151
MTRDI
1156
YETDY
1161
YRKGG
1166
KGLLP
1171
VRWMS
1176
PESLK
1181
DGVFT
1186
TYSDV
1191
WSFGV
1196
VLWEI
1201
ATLAE
1206
QPYQG
1211
LSNEQ
1216
VLRFV
1221
MEGGL
1226
LDKPD
1231
NCPDM
1236
LFELM
1241
RMCWQ
1246
YNPKM
1251
RPSFL
1256
EIISS
1261
IKEEM
1266
EPGFR
1271
EVSFY
1276
YSEEN
1281
KLPEP
1286
EELDL
1291
EPENM
1296
ESVPL
1301
DPSAS
1306
SSSLP
1311
LPDRH
1316
SGHKA
1321
ENGPG
1326
PGVLV
1331
LRASF
1336
DERQP
1341
YAHMN
1346
GGRKN
1351
ERALP
1356
LPQSS
1361
TC
1366
Mutation Information
DNA mutation:
None
Peptide Range:
300 ~ 324
Mut AA position:
312 (13 in Wild Type peptide)
Alignment
Wild Type:
"DGECMQECPSGFIRNGSQSMYCIPC
||||||||||||.||||||||||||
Mutant:
DGECMQECPSGFFRNGSQSMYCIPC"
reference

Science, 2015

Immunogenicity of somatic mutations in human gastrointestinal cancers

Gene Name (from Reference) IGF1R

clinic trial
Checkpoint Blockade

None

ACT

None

Vaccination

None

Curative Effect

None

experiment
minimal_peptide

None

Antigen Type

TMG RNA

T-cell Source

TILs

APC Type

autologous DCs

Assay

IFNg ELISPOT assay