Immunogenicity 4986

summary
Sample ID
3942
Response
Negative
Tumor Type
Rectal cancer
Gene Symbol
BRD4
Transcript ID
NM_058243
HLA INFO
DQA*02:01 / DQB*02:02
TCR INFO

No TCR info found!

T cell Tumor cell { DQA*02:01 DQB*02:02
sequence
Full length protein sequence (1362 aa)
MSAES
1
GPGTR
6
LRNLP
11
VMGDG
16
LETSQ
21
MSTTQ
26
AQAQP
31
QPANA
36
ASTNP
41
PPPET
46
SNPNK
51
PKRQT
56
NQLQY
61
LLRVV
66
LKTLW
71
KHQFA
76
WPFQQ
81
PVDAV
86
KLNLP
91
DYYKI
96
IKTPM
101
DMGTI
106
KKRLE
111
NNYYW
116
NAQEC
121
IQDFN
126
TMFTN
131
CYIYN
136
KPGDD
141
IVLMA
146
EALEK
151
LFLQK
156
INELP
161
TEETE
166
IMIVQ
171
AKGRG
176
RGRKE
181
TGTAK
186
PGVST
191
VPNTT
196
QASTP
201
PQTQT
206
PQPNP
211
PPVQA
216
TPHPF
221
PAVTP
226
DLIVQ
231
TPVMT
236
VVPPQ
241
PLQTP
246
PPVPP
251
QPQPP
256
PAPAP
261
QPVQS
266
HPPII
271
AATPQ
276
PVKTK
281
KGVKR
286
KADTT
291
TPTTI
296
DPIHE
301
PPSLP
306
PEPKT
311
TKLGQ
316
RRESS
321
RPVKP
326
PKKDV
331
PDSQQ
336
HPAPE
341
KSSKV
346
SEQLK
351
CCSGI
356
LKEMF
361
AKKHA
366
AYAWP
371
FYKPV
376
DVEAL
381
GLHDY
386
CDIIK
391
HPMDM
396
STIKS
401
KLEAR
406
EYRDA
411
QEFGA
416
DVRLM
421
FSNCY
426
KYNPP
431
DHEVV
436
AMARK
441
LQDVF
446
EMRFA
451
KMPDE
456
PEEPV
461
VAVSS
466
PAVPP
471
PTKVV
476
APPSS
481
SDSSS
486
DSSSD
491
SDSST
496
DDSEE
501
ERAQR
506
LAELQ
511
EQLKA
516
VHEQL
521
AALSQ
526
PQQNK
531
PKKKE
536
KDKKE
541
KKKEK
546
HKRKE
551
EVEEN
556
KKSKA
561
KEPPP
566
KKTKK
571
NNSSN
576
SNVSK
581
KEPAP
586
MKSKP
591
PPTYE
596
SEEED
601
KCKPM
606
SYEEK
611
RQLSL
616
DINKL
621
PGEKL
626
GRVVH
631
IIQSR
636
EPSLK
641
NSNPD
646
EIEID
651
FETLK
656
PSTLR
661
ELERY
666
VTSCL
671
RKKRK
676
PQAEK
681
VDVIA
686
GSSKM
691
KGFSS
696
SESES
701
SSESS
706
SSDSE
711
DSETE
716
MAPKS
721
KKKGH
726
PGREQ
731
KKHHH
736
HHHQQ
741
MQQAP
746
APVPQ
751
QPPPP
756
PQQPP
761
PPPPP
766
QQQQQ
771
PPPPP
776
PPPSM
781
PQQAA
786
PAMKS
791
SPPPF
796
IATQV
801
PVLEP
806
QLPGS
811
VFDPI
816
GHFTQ
821
PILHL
826
PQPEL
831
PPHLP
836
QPPEH
841
STPPH
846
LNQHA
851
VVSPP
856
ALHNA
861
LPQQP
866
SRPSN
871
RAAAL
876
PPKPA
881
RPPAV
886
SPALT
891
QTPLL
896
PQPPM
901
AQPPQ
906
VLLED
911
EEPPA
916
PPLTS
921
MQMQL
926
YLQQL
931
QKVQP
936
PTPLL
941
PSVKV
946
QSQPP
951
PPLPP
956
PPHPS
961
VQQQL
966
QQQPP
971
PPPPP
976
QPQPP
981
PQQQH
986
QPPPR
991
PVHLQ
996
PMQFS
1001
THIQQ
1006
PPPPQ
1011
GQQPP
1016
HPPPG
1021
QQPPP
1026
PQPAK
1031
PQQVI
1036
QHHHS
1041
PRHHK
1046
SDPYS
1051
TGHLR
1056
EAPSP
1061
LMIHS
1066
PQMSQ
1071
FQSLT
1076
HQSPP
1081
QQNVQ
1086
PKKQE
1091
LRAAS
1096
VVQPQ
1101
PLVVV
1106
KEEKI
1111
HSPII
1116
RSEPF
1121
SPSLR
1126
PEPPK
1131
HPESI
1136
KAPVH
1141
LPQRP
1146
EMKPV
1151
DVGRP
1156
VIRPP
1161
EQNAP
1166
PPGAP
1171
DKDKQ
1176
KQEPK
1181
TPVAP
1186
KKDLK
1191
IKNMG
1196
SWASL
1201
VQKHP
1206
TTPSS
1211
TAKSS
1216
SDSFE
1221
QFRRA
1226
AREKE
1231
EREKA
1236
LKAQA
1241
EHAEK
1246
EKERL
1251
RQERM
1256
RSRED
1261
EDALE
1266
QARRA
1271
HEEAR
1276
RRQEQ
1281
QQQQR
1286
QEQQQ
1291
QQQQQ
1296
AAAVA
1301
AAATP
1306
QAQSS
1311
QPQSM
1316
LDQQR
1321
ELARK
1326
REQER
1331
RRREA
1336
MAATI
1341
DMNFQ
1346
SDLLS
1351
IFEEN
1356
LF
1361
Mutation Information
DNA mutation:
None
Peptide Range:
1260 ~ 1284
Mut AA position:
1272 (13 in Wild Type peptide)
Alignment
Wild Type:
"MRSREDEDALEQARRAHEEARRRQE
||||||||||||.||||||||||||
Mutant:
MRSREDEDALEQTRRAHEEARRRQE"
reference

Science, 2015

Immunogenicity of somatic mutations in human gastrointestinal cancers

Gene Name (from Reference) BRD4

clinic trial
Checkpoint Blockade

None

ACT

None

Vaccination

None

Curative Effect

None

experiment
minimal_peptide

None

Antigen Type

TMG RNA

T-cell Source

TILs

APC Type

autologous DCs

Assay

IFNg ELISPOT assay