Immunogenicity 5038

summary
Sample ID
4007
Response
Negative
Tumor Type
Colon cancer
Gene Symbol
VCL
Transcript ID
NM_014000
HLA INFO
A*03:01
TCR INFO

No TCR info found!

T cell Tumor cell A*03:01
sequence
Full length protein sequence (1134 aa)
MPVFH
1
TRTIE
6
SILEP
11
VAQQI
16
SHLVI
21
MHEEG
26
EVDGK
31
AIPDL
36
TAPVA
41
AVQAA
46
VSNLV
51
RVGKE
56
TVQTT
61
EDQIL
66
KRDMP
71
PAFIK
76
VENAC
81
TKLVQ
86
AAQML
91
QSDPY
96
SVPAR
101
DYLID
106
GSRGI
111
LSGTS
116
DLLLT
121
FDEAE
126
VRKII
131
RVCKG
136
ILEYL
141
TVAEV
146
VETME
151
DLVTY
156
TKNLG
161
PGMTK
166
MAKMI
171
DERQQ
176
ELTHQ
181
EHRVM
186
LVNSM
191
NTVKE
196
LLPVL
201
ISAMK
206
IFVTT
211
KNSKN
216
QGIEE
221
ALKNR
226
NFTVE
231
KMSAE
236
INEII
241
RVLQL
246
TSWDE
251
DAWAS
256
KDTEA
261
MKRAL
266
ASIDS
271
KLNQA
276
KGWLR
281
DPSAS
286
PGDAG
291
EQAIR
296
QILDE
301
AGKVG
306
ELCAG
311
KERRE
316
ILGTC
321
KMLGQ
326
MTDQV
331
ADLRA
336
RGQGS
341
SPVAM
346
QKAQQ
351
VSQGL
356
DVLTA
361
KVENA
366
ARKLE
371
AMTNS
376
KQSIA
381
KKIDA
386
AQNWL
391
ADPNG
396
GPEGE
401
EQIRG
406
ALAEA
411
RKIAE
416
LCDDP
421
KERDD
426
ILRSL
431
GEISA
436
LTSKL
441
ADLRR
446
QGKGD
451
SPEAR
456
ALAKQ
461
VATAL
466
QNLQT
471
KTNRA
476
VANSR
481
PAKAA
486
VHLEG
491
KIEQA
496
QRWID
501
NPTVD
506
DRGVG
511
QAAIR
516
GLVAE
521
GHRLA
526
NVMMG
531
PYRQD
536
LLAKC
541
DRVDQ
546
LTAQL
551
ADLAA
556
RGEGE
561
SPQAR
566
ALASQ
571
LQDSL
576
KDLKA
581
RMQEA
586
MTQEV
591
SDVFS
596
DTTTP
601
IKLLA
606
VAATA
611
PPDAP
616
NREEV
621
FDERA
626
ANFEN
631
HSGKL
636
GATAE
641
KAAAV
646
GTANK
651
STVEG
656
IQASV
661
KTARE
666
LTPQV
671
VSAAR
676
ILLRN
681
PGNQA
686
AYEHF
691
ETMKN
696
QWIDN
701
VEKMT
706
GLVDE
711
AIDTK
716
SLLDA
721
SEEAI
726
KKDLD
731
KCKVA
736
MANIQ
741
PQMLV
746
AGATS
751
IARRA
756
NRILL
761
VAKRE
766
VENSE
771
DPKFR
776
EAVKA
781
ASDEL
786
SKTIS
791
PMVMD
796
AKAVA
801
GNISD
806
PGLQK
811
SFLDS
816
GYRIL
821
GAVAK
826
VREAF
831
QPQEP
836
DFPPP
841
PPDLE
846
QLRLT
851
DELAP
856
PKPPL
861
PEGEV
866
PPPRP
871
PPPEE
876
KDEEF
881
PEQKA
886
GEVIN
891
QPMMM
896
AARQL
901
HDEAR
906
KWSSK
911
PGIPA
916
AEVGI
921
GVVAE
926
ADAAD
931
AAGFP
936
VPPDM
941
EDDYE
946
PELLL
951
MPSNQ
956
PVNQP
961
ILAAA
966
QSLHR
971
EATKW
976
SSKGN
981
DIIAA
986
AKRMA
991
LLMAE
996
MSRLV
1001
RGGSG
1006
TKRAL
1011
IQCAK
1016
DIAKA
1021
SDEVT
1026
RLAKE
1031
VAKQC
1036
TDKRI
1041
RTNLL
1046
QVCER
1051
IPTIS
1056
TQLKI
1061
LSTVK
1066
ATMLG
1071
RTNIS
1076
DEESE
1081
QATEM
1086
LVHNA
1091
QNLMQ
1096
SVKET
1101
VREAE
1106
AASIK
1111
IRTDA
1116
GFTLR
1121
WVRKT
1126
PWYQ
1131
Mutation Information
DNA mutation:
None
Peptide Range:
217 ~ 241
Mut AA position:
229 (13 in Wild Type peptide)
Alignment
Wild Type:
"NSKNQGIEEALKNRNFTVEKMSAEI
||||||||||||.||||||||||||
Mutant:
NSKNQGIEEALKKRNFTVEKMSAEI"
reference

Science, 2015

Immunogenicity of somatic mutations in human gastrointestinal cancers

Gene Name (from Reference) VCL

clinic trial
Checkpoint Blockade

None

ACT

None

Vaccination

None

Curative Effect

None

experiment
minimal_peptide

None

Antigen Type

TMG RNA

T-cell Source

TILs

APC Type

autologous DCs

Assay

IFNg ELISPOT assay