Immunogenicity 5224
Sample ID
3948
Response
Negative
Tumor Type
Esophageal cancer
Gene Symbol
AKAP12
Transcript ID
NM_005100
HLA INFO
A*25:01
TCR INFO
No TCR info found!
Full length protein sequence (1782 aa)
MGAGS
1
STEQR
6
SPEQP
11
PEGSS
16
TPAEP
21
EPSGG
26
GPSAE
31
AAPDT
36
TADPA
41
IAASD
46
PATKL
51
LQKNG
56
QLSTI
61
NGVAE
66
QDELS
71
LQEGD
76
LNGQK
81
GALNG
86
QGALN
91
SQEEE
96
EVIVT
101
EVGQR
106
DSEDV
111
SKRDS
116
DKEMA
121
TKSAV
126
VHDIT
131
DDGQE
136
ETPEI
141
IEQIP
146
SSESN
151
LEELT
156
QPTES
161
QANDI
166
GFKKV
171
FKFVG
176
FKFTV
181
KKDKT
186
EKPDT
191
VQLLT
196
VKKDE
201
GEGAA
206
GAGDH
211
KDPSL
216
GAGEA
221
ASKES
226
EPKQS
231
TEKPE
236
ETLKR
241
EQSHA
246
EISPP
251
AESGQ
256
AVEEC
261
KEEGE
266
EKQEK
271
EPSKS
276
AESPT
281
SPVTS
286
ETGST
291
FKKFF
296
TQGWA
301
GWRKK
306
TSFRK
311
PKEDE
316
VEASE
321
KKKEQ
326
EPEKV
331
DTEED
336
GKAEV
341
ASEKL
346
TASEQ
351
AHPQE
356
PAESA
361
HEPRL
366
SAEYE
371
KVELP
376
SEEQV
381
SGSQG
386
PSEEK
391
PAPLA
396
TEVFD
401
EKIEV
406
HQEEV
411
VAEVH
416
VSTVE
421
ERTEE
426
QKTEV
431
EETAG
436
SVPAE
441
ELVEM
446
DAEPQ
451
EAEPA
456
KELVK
461
LKETC
466
VSGED
471
PTQGA
476
DLSPD
481
EKVLS
486
KPPEG
491
VVSEV
496
EMLSS
501
QERMK
506
VQGSP
511
LKKLF
516
TSTGL
521
KKLSG
526
KKQKG
531
KRGGG
536
DEESG
541
EHTQV
546
PADSP
551
DSQEE
556
QKGES
561
SASSP
566
EEPEE
571
ITCLE
576
KGLAE
581
VQQDG
586
EAEEG
591
ATSDG
596
EKKRE
601
GVTPW
606
ASFKK
611
MVTPK
616
KRVRR
621
PSESD
626
KEDEL
631
DKVKS
636
ATLSS
641
TESTA
646
SEMQE
651
EMKGS
656
VEEPK
661
PEEPK
666
RKVDT
671
SVSWE
676
ALICV
681
GSSKK
686
RARRG
691
SSSDE
696
EGGPK
701
AMGGD
706
HQKAD
711
EAGKD
716
KETGT
721
DGILA
726
GSQEH
731
DPGQG
736
SSSPE
741
QAGSP
746
TEGEG
751
VSTWE
756
SFKRL
761
VTPRK
766
KSKSK
771
LEEKS
776
EDSIA
781
GSGVE
786
HSTPD
791
TEPGK
796
EESWV
801
SIKKF
806
IPGRR
811
KKRPD
816
GKQEQ
821
APVED
826
AGPTG
831
ANEDD
836
SDVPA
841
VVPLS
846
EYDAV
851
EREKM
856
EAQQA
861
QKSAE
866
QPEQK
871
AATEV
876
SKELS
881
ESQVH
886
MMAAA
891
VADGT
896
RAATI
901
IEERS
906
PSWIS
911
ASVTE
916
PLEQV
921
EAEAA
926
LLTEE
931
VLERE
936
VIAEE
941
EPPTV
946
TEPLP
951
ENREA
956
RGDTV
961
VSEAE
966
LTPEA
971
VTAAE
976
TAGPL
981
GAEEG
986
TEASA
991
AEETT
996
EMVSA
1001
VSQLT
1006
DSPDT
1011
TEEAT
1016
PVQEV
1021
EGGVP
1026
DIEEQ
1031
ERRTQ
1036
EVLQA
1041
VAEKV
1046
KEESQ
1051
LPGTG
1056
GPEDV
1061
LQPVQ
1066
RAEAE
1071
RPEEQ
1076
AEASG
1081
LKKET
1086
DVVLK
1091
VDAQE
1096
AKTEP
1101
FTQGK
1106
VVGQT
1111
TPESF
1116
EKAPQ
1121
VTESI
1126
ESSEL
1131
VTTCQ
1136
AETLA
1141
GVKSQ
1146
EMVME
1151
QAIPP
1156
DSVET
1161
PTDSE
1166
TDGST
1171
PVADF
1176
DAPGT
1181
TQKDE
1186
IVEIH
1191
EENEV
1196
ASGTQ
1201
SGGTE
1206
AEAVP
1211
AQKER
1216
PPAPS
1221
SFVFQ
1226
EETKE
1231
QSKME
1236
DTLEH
1241
TDKEV
1246
SVETV
1251
SILSK
1256
TEGTQ
1261
EADQY
1266
ADEKT
1271
KDVPF
1276
FEGLE
1281
GSIDT
1286
GITVS
1291
REKVT
1296
EVALK
1301
GEGTE
1306
EAECK
1311
KDDAL
1316
ELQSH
1321
AKSPP
1326
SPVER
1331
EMVVQ
1336
VEREK
1341
TEAEP
1346
THVNE
1351
EKLEH
1356
ETAVT
1361
VSEEV
1366
SKQLL
1371
QTVNV
1376
PIIDG
1381
AKEVS
1386
SLEGS
1391
PPPCL
1396
GQEEA
1401
VCTKI
1406
QVQSS
1411
EASFT
1416
LTAAA
1421
EEEKV
1426
LGETA
1431
NILET
1436
GETLE
1441
PAGAH
1446
LVLEE
1451
KSSEK
1456
NEDFA
1461
AHPGE
1466
DAVPT
1471
GPDCQ
1476
AKSTP
1481
VIVSA
1486
TTKKG
1491
LSSDL
1496
EGEKT
1501
TSLKW
1506
KSDEV
1511
DEQVA
1516
CQEVK
1521
VSVAI
1526
EDLEP
1531
ENGIL
1536
ELETK
1541
SSKLV
1546
QNIIQ
1551
TAVDQ
1556
FVRTE
1561
ETATE
1566
MLTSE
1571
LQTQA
1576
HVIKA
1581
DSQDA
1586
GQETE
1591
KEGEE
1596
PQASA
1601
QDETP
1606
ITSAK
1611
EESES
1616
TAVGQ
1621
AHSDI
1626
SKDMS
1631
EASEK
1636
TMTVE
1641
VEGST
1646
VNDQQ
1651
LEEVV
1656
LPSEE
1661
EGGGA
1666
GTKSV
1671
PEDDG
1676
HALLA
1681
ERIEK
1686
SLVEP
1691
KEDEK
1696
GDDVD
1701
DPENQ
1706
NSALA
1711
DTDAS
1716
GGLTK
1721
ESPDT
1726
NGPKQ
1731
KEKED
1736
AQEVE
1741
LQEGK
1746
VHSES
1751
DKAIT
1756
PQAQE
1761
ELQKQ
1766
ERESA
1771
KSELT
1776
ES
1781
Mutation Information
DNA mutation:
None
Peptide Range:
1270 ~ 1294
Mut AA position:
1282 (13 in Wild Type peptide)
Alignment
Wild Type:
"YADEKTKDVPFFEGLEGSIDTGITV
||||||||||||.||||||||||||
Mutant:
YADEKTKDVPFFKGLEGSIDTGITV"
Science, 2015
Immunogenicity of somatic mutations in human gastrointestinal cancersGene Name (from Reference) AKAP12
Checkpoint
Blockade
None
ACT
None
Vaccination
None
Curative
Effect
None
minimal_peptide
None
Antigen
Type
TMG RNA
T-cell
Source
TILs
APC
Type
autologous DCs
Assay
IFNg ELISPOT assay