Immunogenicity 5273

summary
Sample ID
3948
Response
Negative
Tumor Type
Esophageal cancer
Gene Symbol
WWC3
Transcript ID
NM_015691
HLA INFO
A*02:01
TCR INFO

No TCR info found!

T cell Tumor cell A*02:01
sequence
Full length protein sequence (1092 aa)
MDHIN
1
KLTQI
6
EDPRE
11
QWRRE
16
QERML
21
KEYLI
26
VAQEA
31
LNAKK
36
EIYQI
41
KQQRF
46
ELAQE
51
EYQQL
56
HKMCE
61
DDSRS
66
YASSF
71
SGYST
76
NTKYD
81
PHQIK
86
AEIAS
91
RRDRL
96
SRLKR
101
ELTQM
106
KQELQ
111
YKEKG
116
VETLQ
121
EIDRK
126
MSSTH
131
TSYKL
136
DEAQA
141
IMSEL
146
RTIKK
151
AICTG
156
EKERR
161
DLMHS
166
LAKLT
171
DSFKN
176
SCSVT
181
DSLVD
186
FPHHV
191
GVPGD
196
AGVPQ
201
QFCDA
206
GSQTD
211
IIGEF
216
VFDDK
221
TRLVD
226
RVRLN
231
WQYEE
236
ARKRV
241
ANIQQ
246
QLARL
251
DNESW
256
PSTAE
261
ADRDR
266
LQLIK
271
EKEAL
276
LQELQ
281
LIIAQ
286
RRSAG
291
DVARL
296
EEERE
301
RLEEE
306
LRRAR
311
ATSAQ
316
GATER
321
ILLQE
326
KRNCL
331
LMQLE
336
EATRL
341
TSYLQ
346
SQLKS
351
LCAST
356
LTVSS
361
GSSRG
366
SLASS
371
RGSLA
376
SSRGS
381
LSSVS
386
FTDIY
391
GLPQY
396
EKPDA
401
EGSQL
406
LRFDL
411
IPFDS
416
LGRDA
421
PFSEP
426
PGPSG
431
FHKQR
436
RSLDT
441
PQSLA
446
SLSSR
451
SSLSS
456
LSPPS
461
SPLDT
466
PFLPA
471
SRDSP
476
LAQLA
481
DSCEG
486
PGLGA
491
LDRLR
496
AHASA
501
MGDED
506
LPGMA
511
ALQPH
516
GVPGD
521
GEGPH
526
ERGPP
531
PASAP
536
VGGTV
541
TLRED
546
SAKRL
551
ERRAR
556
RISAC
561
LSDYS
566
LASDS
571
GVFEP
576
LTKRN
581
EDAEE
586
PAYGD
591
TASNG
596
DPQIH
601
VGLLR
606
DSGSE
611
CLLVH
616
VLQLK
621
NPAGL
626
AVKED
631
CKVHI
636
RVYLP
641
PLDSG
646
TPNTY
651
CSKAL
656
EFQVP
661
LVFNE
666
VFRIP
671
VHSSA
676
LTLKS
681
LQLYV
686
CSVTP
691
QLQEE
696
LLGIA
701
QINLA
706
DYDSL
711
SEMQL
716
RWHSV
721
QVFTS
726
SEPSR
731
TREAG
736
CAGES
741
SARDP
746
AHTIS
751
ISGKT
756
DAVTV
761
LLART
766
TAQLQ
771
AVERE
776
LAEER
781
AKLEY
786
TEEEV
791
LEMER
796
KEEQA
801
EAISE
806
RSWQA
811
DSVDS
816
GCSNC
821
TQTSP
826
PYPEP
831
CCMGI
836
DSILG
841
HPFAA
846
QAGPY
851
SPEKF
856
QPSPL
861
KVDKE
866
TNTED
871
LFLEE
876
AASLV
881
KERPS
886
RRARG
891
SPFVR
896
SGTIV
901
RSQTF
906
SPGAR
911
SQYVC
916
RLYRS
921
DSDSS
926
TLPRK
931
SPFVR
936
NTLER
941
RTLRY
946
KQSCR
951
SSLAE
956
LMART
961
SLDLE
966
LDLQA
971
SRTRQ
976
RQLNE
981
ELCAL
986
RELRQ
991
RLEDA
996
QLRGQ
1001
TDLPP
1006
WVLRD
1011
ERLRG
1016
LLREA
1021
ERQTR
1026
QTKLD
1031
YRHEQ
1036
AAEKM
1041
LKKAS
1046
KEIYQ
1051
LRGQS
1056
HKEPI
1061
QVQTF
1066
REKIA
1071
FFTRP
1076
RINIP
1081
PLPAD
1086
DV
1091
Mutation Information
DNA mutation:
None
Peptide Range:
287 ~ 311
Mut AA position:
299 (13 in Wild Type peptide)
Alignment
Wild Type:
"IIAQRRSAGDVARLEEERERLEEEL
||||||||||||.||||||||||||
Mutant:
IIAQRRSAGDVAWLEEERERLEEEL"
reference

Science, 2015

Immunogenicity of somatic mutations in human gastrointestinal cancers

Gene Name (from Reference) WWC3

clinic trial
Checkpoint Blockade

None

ACT

None

Vaccination

None

Curative Effect

None

experiment
minimal_peptide

None

Antigen Type

TMG RNA

T-cell Source

TILs

APC Type

autologous DCs

Assay

IFNg ELISPOT assay