Immunogenicity 5434

summary
Sample ID
3948
Response
Negative
Tumor Type
Esophageal cancer
Gene Symbol
HRNR
Transcript ID
NM_001009931
HLA INFO
DRB*15:02
TCR INFO

No TCR info found!

T cell Tumor cell DRB*15:02
sequence
Full length protein sequence (2850 aa)
MPKLL
1
QGVIT
6
VIDVF
11
YQYAT
16
QHGEY
21
DTLNK
26
AELKE
31
LLENE
36
FHQIL
41
KNPND
46
PDTVD
51
IILQS
56
LDRDH
61
NKKVD
66
FTEYL
71
LMIFK
76
LVQAR
81
NKIIG
86
KDYCQ
91
VSGSK
96
LRDDT
101
HQHQE
106
EQEET
111
EKEEN
116
KRQES
121
SFSHS
126
SWSAG
131
ENDSY
136
SRNVR
141
GSLKP
146
GTESI
151
SRRLS
156
FQRDF
161
SGQHN
166
SYSGQ
171
SSSYG
176
EQNSD
181
SHQSS
186
GRGQC
191
GSGSG
196
QSPNY
201
GQHGS
206
GSGQS
211
SSNDT
216
HGSGS
221
GQSSG
226
FSQHK
231
SSSGQ
236
SSGYS
241
QHGSG
246
SGHSS
251
GYGQH
256
GSRSG
261
QSSRG
266
ERHRS
271
SSGSS
276
SSYGQ
281
HGSGS
286
RQSLG
291
HGRQG
296
SGSRQ
301
SPSHV
306
RHGSG
311
SGHSS
316
SHGQH
321
GSGSS
326
YSYSR
331
GHYES
336
GSGQT
341
SGFGQ
346
HESGS
351
GQSSG
356
YSKHG
361
SGSGH
366
SSSQG
371
QHGST
376
SGQAS
381
SSGQH
386
GSSSR
391
QSSSY
396
GQHES
401
ASRHS
406
SGRGQ
411
HSSGS
416
GQSPG
421
HGQRG
426
SGSGQ
431
SPSSG
436
QHGTG
441
FGRSS
446
SSGPY
451
VSGSG
456
YSSGF
461
GHHES
466
SSEHS
471
SGYTQ
476
HGSGS
481
GHSSG
486
HGQHG
491
SRSGQ
496
SSRGE
501
RQGSS
506
AGSSS
511
SYGQH
516
GSGSR
521
QSLGH
526
SRHGS
531
GSGQS
536
PSPSR
541
GRHES
546
GSRQS
551
SSYGP
556
HGYGS
561
GRSSS
566
RGPYE
571
SGSGH
576
SSGLG
581
HQESR
586
SGQSS
591
GYGQH
596
GSSSG
601
HSSTH
606
GQHGS
611
TSGQS
616
SSCGQ
621
HGATS
626
GQSSS
631
HGQHG
636
SGSSQ
641
SSRYG
646
QQGSG
651
SGQSP
656
SRGRH
661
GSDFG
666
HSSSY
671
GQHGS
676
GSGWS
681
SSNGP
686
HGSVS
691
GQSSG
696
FGHKS
701
GSGQS
706
SGYSQ
711
HGSGS
716
SHSSG
721
YRKHG
726
SRSGQ
731
SSRSE
736
QHGSS
741
SGLSS
746
SYGQH
751
GSGSH
756
QSSGH
761
GRQGS
766
GSGHS
771
PSRVR
776
HGSSS
781
GHSSS
786
HGQHG
791
SGTSC
796
SSSCG
801
HYESG
806
SGQAS
811
GFGQH
816
ESGSG
821
QGYSQ
826
HGSAS
831
GHFSS
836
QGRHG
841
STSGQ
846
SSSSG
851
QHDSS
856
SGQSS
861
SYGQH
866
ESASH
871
HASGR
876
GRHGS
881
GSGQS
886
PGHGQ
891
RGSGS
896
GQSPS
901
YGRHG
906
SGSGR
911
SSSSG
916
RHGSG
921
SGQSS
926
GFGHK
931
SSSGQ
936
SSGYT
941
QHGSG
946
SGHSS
951
SYEQH
956
GSRSG
961
QSSRS
966
EQHGS
971
SSGSS
976
SSYGQ
981
HGSGS
986
RQSLG
991
HGQHG
996
SGSGQ
1001
SPSPS
1006
RGRHG
1011
SGSGQ
1016
SSSYG
1021
PYRSG
1026
SGWSS
1031
SRGPY
1036
ESGSG
1041
HSSGL
1046
GHRES
1051
RSGQS
1056
SGYGQ
1061
HGSSS
1066
GHSST
1071
HGQHG
1076
STSGQ
1081
SSSCG
1086
QHGAS
1091
SGQSS
1096
SHGQH
1101
GSGSS
1106
QSSGY
1111
GRQGS
1116
GSGQS
1121
PGHGQ
1126
RGSGS
1131
RQSPS
1136
YGRHG
1141
SGSGR
1146
SSSSG
1151
QHGSG
1156
LGESS
1161
GFGHH
1166
ESSSG
1171
QSSSY
1176
SQHGS
1181
GSGHS
1186
SGYGQ
1191
HGSRS
1196
GQSSR
1201
GERHG
1206
SSSGS
1211
SSHYG
1216
QHGSG
1221
SRQSS
1226
GHGRQ
1231
GSGSG
1236
HSPSR
1241
GRHGS
1246
GLGHS
1251
SSHGQ
1256
HGSGS
1261
GRSSS
1266
RGPYE
1271
SRSGH
1276
SSVFG
1281
QHESG
1286
SGHSS
1291
AYSQH
1296
GSGSG
1301
HFCSQ
1306
GQHGS
1311
TSGQS
1316
STFDQ
1321
EGSST
1326
GQSSS
1331
YGHRG
1336
SGSSQ
1341
SSGYG
1346
RHGAG
1351
SGQSP
1356
SRGRH
1361
GSGSG
1366
HSSSY
1371
GQHGS
1376
GSGWS
1381
SSSGR
1386
HGSGS
1391
GQSSG
1396
FGHHE
1401
SSSWQ
1406
SSGCT
1411
QHGSG
1416
SGHSS
1421
SYEQH
1426
GSRSG
1431
QSSRG
1436
ERHGS
1441
SSGSS
1446
SSYGQ
1451
HGSGS
1456
RQSLG
1461
HGQHG
1466
SGSGQ
1471
SPSPS
1476
RGRHG
1481
SGSGQ
1486
SSSYS
1491
PYGSG
1496
SGWSS
1501
SRGPY
1506
ESGSS
1511
HSSGL
1516
GHRES
1521
RSGQS
1526
SGYGQ
1531
HGSSS
1536
GHSST
1541
HGQHG
1546
STSGQ
1551
SSSCG
1556
QHGAS
1561
SGQSS
1566
SHGQH
1571
GSGSS
1576
QSSGY
1581
GRQGS
1586
GSGQS
1591
PGHGQ
1596
RGSGS
1601
RQSPS
1606
YGRHG
1611
SGSGR
1616
SSSSG
1621
QHGSG
1626
LGESS
1631
GFGHH
1636
ESSSG
1641
QSSSY
1646
SQHGS
1651
GSGHS
1656
SGYGQ
1661
HGSRS
1666
GQSSR
1671
GERHG
1676
SSSRS
1681
SSRYG
1686
QHGSG
1691
SRQSS
1696
GHGRQ
1701
GSGSG
1706
QSPSR
1711
GRHGS
1716
GLGHS
1721
SSHGQ
1726
HGSGS
1731
GRSSS
1736
RGPYE
1741
SRSGH
1746
SSVFG
1751
QHESG
1756
SGHSS
1761
AYSQH
1766
GSGSG
1771
HFCSQ
1776
GQHGS
1781
TSGQS
1786
STFDQ
1791
EGSST
1796
GQSSS
1801
HGQHG
1806
SGSSQ
1811
SSSYG
1816
QQGSG
1821
SGQSP
1826
SRGRH
1831
GSGSG
1836
HSSSY
1841
GQHGS
1846
GSGWS
1851
SSSGR
1856
HGSGS
1861
GQSSG
1866
FGHHE
1871
SSSWQ
1876
SSGYT
1881
QHGSG
1886
SGHSS
1891
SYEQH
1896
GSRSG
1901
QSSRG
1906
EQHGS
1911
SSGSS
1916
SSYGQ
1921
HGSGS
1926
RQSLG
1931
HGQHG
1936
SGSGQ
1941
SPSPS
1946
RGRHG
1951
SGSGQ
1956
SSSYG
1961
PYGSG
1966
SGWSS
1971
SRGPY
1976
ESGSG
1981
HSSGL
1986
GHRES
1991
RSGQS
1996
SGYGQ
2001
HGSSS
2006
GHSST
2011
HGQHG
2016
SASGQ
2021
SSSCG
2026
QHGAS
2031
SGQSS
2036
SHGQH
2041
GSGSS
2046
QSSGY
2051
GRQGS
2056
GSGQS
2061
PGHGQ
2066
RGSGS
2071
RQSPS
2076
YGRHG
2081
SGSGR
2086
SSSSG
2091
QHGPG
2096
LGESS
2101
GFGHH
2106
ESSSG
2111
QSSSY
2116
SQHGS
2121
GSGHS
2126
SGYGQ
2131
HGSRS
2136
GQSSR
2141
GERHG
2146
SSSGS
2151
SSRYG
2156
QHGSG
2161
SRQSS
2166
GHGRQ
2171
GSGSG
2176
HSPSR
2181
GRHGS
2186
GSGHS
2191
SSHGQ
2196
HGSGS
2201
GRSSS
2206
RGPYE
2211
SRSGH
2216
SSVFG
2221
QHESG
2226
SGHSS
2231
AYSQH
2236
GSGSG
2241
HFCSQ
2246
GQHGS
2251
TSGQS
2256
STFDQ
2261
EGSST
2266
GQSSS
2271
HGQHG
2276
SGSSQ
2281
SSSYG
2286
QQGSG
2291
SGQSP
2296
SRGRH
2301
GSGSG
2306
HSSSY
2311
GQHGS
2316
GSGWS
2321
SSSGR
2326
HGSGS
2331
GQSSG
2336
FGHHE
2341
SSSWQ
2346
SSGYT
2351
QHGSG
2356
SGHSS
2361
SYEQH
2366
GSRSG
2371
QSSRG
2376
ERHGS
2381
SSGSS
2386
SSYGQ
2391
HGSGS
2396
RQSLG
2401
HGQHG
2406
SGSGQ
2411
SPSPS
2416
RGRHG
2421
SGSGQ
2426
SSSYS
2431
PYGSG
2436
SGWSS
2441
SRGPY
2446
ESGSG
2451
HSSGL
2456
GHRES
2461
RSGQS
2466
SGYGQ
2471
HGSSS
2476
GHSST
2481
HGQHG
2486
STSGQ
2491
SSSCG
2496
QHGAS
2501
SGQSS
2506
SHGQH
2511
GSGSS
2516
QSSGY
2521
GRQGS
2526
GSGQS
2531
PGHGQ
2536
RGSGS
2541
RQSPS
2546
YGRHG
2551
SGSGR
2556
SSSSG
2561
QHGSG
2566
LGESS
2571
GFGHH
2576
ESSSG
2581
QSSSY
2586
SQHGS
2591
GSGHS
2596
SGYGQ
2601
HGSRS
2606
GQSSR
2611
GERHG
2616
SSSGS
2621
SSHYG
2626
QHGSG
2631
SRQSS
2636
GHGRQ
2641
GSGSG
2646
QSPSR
2651
GRHGS
2656
GLGHS
2661
SSHGQ
2666
HGSGS
2671
GRSSS
2676
RGPYE
2681
SRLGH
2686
SSVFG
2691
QHESG
2696
SGHSS
2701
AYSQH
2706
GSGSG
2711
HFCSQ
2716
GQHGS
2721
TSGQS
2726
STFDQ
2731
EGSST
2736
GQSSS
2741
YGHRG
2746
SGSSQ
2751
SSGYG
2756
RHGAG
2761
SGQSL
2766
SHGRH
2771
GSGSG
2776
QSSSY
2781
GQHGS
2786
GSGQS
2791
SGYSQ
2796
HGSGS
2801
GQDGY
2806
SYCKG
2811
GSNHD
2816
GGSSG
2821
SYFLS
2826
FPSST
2831
SPYEY
2836
VQEQR
2841
CYFYQ
2846
Mutation Information
DNA mutation:
None
Peptide Range:
1611 ~ 1635
Mut AA position:
1623 (13 in Wild Type peptide)
Alignment
Wild Type:
"YGRHGSGSGRSSSSGQHGSGLGESS
||||||||||||.||||||||||||
Mutant:
YGRHGSGSGRSSTSGQHGSGLGESS"
reference

Science, 2015

Immunogenicity of somatic mutations in human gastrointestinal cancers

Gene Name (from Reference) HRNR

clinic trial
Checkpoint Blockade

None

ACT

None

Vaccination

None

Curative Effect

None

experiment
minimal_peptide

None

Antigen Type

TMG RNA

T-cell Source

TILs

APC Type

autologous DCs

Assay

IFNg ELISPOT assay