Immunogenicity 5529
Sample ID
4032
Response
Negative
Tumor Type
Colon cancer
Gene Symbol
POLA1
Transcript ID
NM_016937
HLA INFO
A*02:01
TCR INFO
No TCR info found!
Full length protein sequence (1462 aa)
MAPVH
1
GDDSL
6
SDSGS
11
FVSSR
16
ARREK
21
KSKKG
26
RQEAL
31
ERLKK
36
AKAGE
41
KYKYE
46
VEDFT
51
GVYEE
56
VDEEQ
61
YSKLV
66
QARQD
71
DDWIV
76
DDDGI
81
GYVED
86
GREIF
91
DDDLE
96
DDALD
101
ADEKG
106
KDGKA
111
RNKDK
116
RNVKK
121
LAVTK
126
PNNIK
131
SMFIA
136
CAGKK
141
TADKA
146
VDLSK
151
DGLLG
156
DILQD
161
LNTET
166
PQITP
171
PPVMI
176
LKKKR
181
SIGAS
186
PNPFS
191
VHTAT
196
AVPSG
201
KIASP
206
VSRKE
211
PPLTP
216
VPLKR
221
AEFAG
226
DDVQV
231
ESTEE
236
EQESG
241
AMEFE
246
DGDFD
251
EPMEV
256
EEVDL
261
EPMAA
266
KAWDK
271
ESEPA
276
EEVKQ
281
EADSG
286
KGTVS
291
YLGSF
296
LPDVS
301
CWDID
306
QEGDS
311
SFSVQ
316
EVQVD
321
SSHLP
326
LVKGA
331
DEEQV
336
FHFYW
341
LDAYE
346
DQYNQ
351
PGVVF
356
LFGKV
361
WIESA
366
ETHVS
371
CCVMV
376
KNIER
381
TLYFL
386
PREMK
391
IDLNT
396
GKETG
401
TPISM
406
KDVYE
411
EFDEK
416
IATKY
421
KIMKF
426
KSKPV
431
EKNYA
436
FEIPD
441
VPEKS
446
EYLEV
451
KYSAE
456
MPQLP
461
QDLKG
466
ETFSH
471
VFGTN
476
TSSLE
481
LFLMN
486
RKIKG
491
PCWLE
496
VKSPQ
501
LLNQP
506
VSWCK
511
VEAMA
516
LKPDL
521
VNVIK
526
DVSPP
531
PLVVM
536
AFSMK
541
TMQNA
546
KNHQN
551
EIIAM
556
AALVH
561
HSFAL
566
DKAAP
571
KPPFQ
576
SHFCV
581
VSKPK
586
DCIFP
591
YAFKE
596
VIEKK
601
NVKVE
606
VAATE
611
RTLLG
616
FFLAK
621
VHKID
626
PDIIV
631
GHNIY
636
GFELE
641
VLLQR
646
INVCK
651
APHWS
656
KIGRL
661
KRSNM
666
PKLGG
671
RSGFG
676
ERNAT
681
CGRMI
686
CDVEI
691
SAKEL
696
IRCKS
701
YHLSE
706
LVQQI
711
LKTER
716
VVIPM
721
ENIQN
726
MYSES
731
SQLLY
736
LLEHT
741
WKDAK
746
FILQI
751
MCELN
756
VLPLA
761
LQITN
766
IAGNI
771
MSRTL
776
MGGRS
781
ERNEF
786
LLLHA
791
FYENN
796
YIVPD
801
KQIFR
806
KPQQK
811
LGDED
816
EEIDG
821
DTNKY
826
KKGRK
831
KAAYA
836
GGLVL
841
DPKVG
846
FYDKF
851
ILLLD
856
FNSLY
861
PSIIQ
866
EFNIC
871
FTTVQ
876
RVASE
881
AQKVT
886
EDGEQ
891
EQIPE
896
LPDPS
901
LEMGI
906
LPREI
911
RKLVE
916
RRKQV
921
KQLMK
926
QQDLN
931
PDLIL
936
QYDIR
941
QKALK
946
LTANS
951
MYGCL
956
GFSYS
961
RFYAK
966
PLAAL
971
VTYKG
976
REILM
981
HTKEM
986
VQKMN
991
LEVIY
996
GDTDS
1001
IMINT
1006
NSTNL
1011
EEVFK
1016
LGNKV
1021
KSEVN
1026
KLYKL
1031
LEIDI
1036
DGVFK
1041
SLLLL
1046
KKKKY
1051
AALVV
1056
EPTSD
1061
GNYVT
1066
KQELK
1071
GLDIV
1076
RRDWC
1081
DLAKD
1086
TGNFV
1091
IGQIL
1096
SDQSR
1101
DTIVE
1106
NIQKR
1111
LIEIG
1116
ENVLN
1121
GSVPV
1126
SQFEI
1131
NKALT
1136
KDPQD
1141
YPDKK
1146
SLPHV
1151
HVALW
1156
INSQG
1161
GRKVK
1166
AGDTV
1171
SYVIC
1176
QDGSN
1181
LTASQ
1186
RAYAP
1191
EQLQK
1196
QDNLT
1201
IDTQY
1206
YLAQQ
1211
IHPVV
1216
ARICE
1221
PIDGI
1226
DAVLI
1231
ATWLG
1236
LDPTQ
1241
FRVHH
1246
YHKDE
1251
ENDAL
1256
LGGPA
1261
QLTDE
1266
EKYRD
1271
CERFK
1276
CPCPT
1281
CGTEN
1286
IYDNV
1291
FDGSG
1296
TDMEP
1301
SLYRC
1306
SNIDC
1311
KASPL
1316
TFTVQ
1321
LSNKL
1326
IMDIR
1331
RFIKK
1336
YYDGW
1341
LICEE
1346
PTCRN
1351
RTRHL
1356
PLQFS
1361
RTGPL
1366
CPACM
1371
KATLQ
1376
PEYSD
1381
KSLYT
1386
QLCFY
1391
RYIFD
1396
AECAL
1401
EKLTT
1406
DHEKD
1411
KLKKQ
1416
FFTPK
1421
VLQDY
1426
RKLKN
1431
TAEQF
1436
LSRSG
1441
YSEVN
1446
LSKLF
1451
AGCAV
1456
KS
1461
Mutation Information
DNA mutation:
None
Peptide Range:
1044 ~ 1068
Mut AA position:
1056 (13 in Wild Type peptide)
Alignment
Wild Type:
"FKSLLLLKKKKYAALVVEPTSDGNY
||||||||||||.||||||||||||
Mutant:
FKSLLLLKKKKYTALVVEPTSDGNY"
Science, 2015
Immunogenicity of somatic mutations in human gastrointestinal cancersGene Name (from Reference) POLA1
Checkpoint
Blockade
None
ACT
None
Vaccination
None
Curative
Effect
None
minimal_peptide
None
Antigen
Type
TMG RNA
T-cell
Source
TILs
APC
Type
autologous DCs
Assay
IFNg ELISPOT assay